Zobrazeno 1 - 10
of 1 407
pro vyhledávání: '"J. Lamont"'
Autor:
Zsofia I. Laszlo, Nicole Hindley, Anna Sanchez Avila, Rachel A. Kline, Samantha L. Eaton, Douglas J. Lamont, Colin Smith, Tara L. Spires-Jones, Thomas M. Wishart, Christopher M. Henstridge
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-20 (2022)
Abstract Increasing evidence suggests synaptic dysfunction is a central and possibly triggering factor in Amyotrophic Lateral Sclerosis (ALS). Despite this, we still know very little about the molecular profile of an ALS synapse. To address this gap,
Externí odkaz:
https://doaj.org/article/a5dc3dda62ae45789b1d7df6f27a7cc3
Autor:
M. Fata Moradali, Shirin Ghods, Heike Bähre, Richard J. Lamont, David A. Scott, Roland Seifert
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Microbial pathogens employ signaling systems through cyclic (di-) nucleotide monophosphates serving as second messengers to increase fitness during pathogenesis. However, signaling schemes via second messengers in Porphyromonas gingivalis, a
Externí odkaz:
https://doaj.org/article/80870980ac724abaa801f36ce71d85d2
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-20 (2022)
Abstract Background Receptor interacting serine/threonine kinase 2 (RIP2), ubiquitous in many tissue/cell types, is the key regulator of immune and inflammatory responses for many diseases, including avian pathogenic E. coli (APEC), which causes a wi
Externí odkaz:
https://doaj.org/article/cdecb95743614ead801e62f9a1bc32cd
Autor:
Christa P. Baker, Iain R. Phair, Alejandro J. Brenes, Abdelmadjid Atrih, Dylan G. Ryan, Roland Bruderer, Albena T. Dinkova-Kostova, Douglas J. Lamont, J. Simon C. Arthur, Andrew J.M. Howden
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101725- (2022)
Summary: Here, we describe an optimized protocol to analyze murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics. We provide a complete step-by-step protocol describing sample preparation utilizing the
Externí odkaz:
https://doaj.org/article/55dbb36cd7934934bcf60bd53c5f3bf4
Autor:
Akito Sakanaka, Masae Kuboniwa, Shuichi Shimma, Samar A. Alghamdi, Shota Mayumi, Richard J. Lamont, Eiichiro Fukusaki, Atsuo Amano
Publikováno v:
mSystems, Vol 7, Iss 4 (2022)
ABSTRACT Fusobacterium nucleatum is a common constituent of the oral microbiota in both periodontal health and disease. Previously, we discovered ornithine cross-feeding between F. nucleatum and Streptococcus gordonii, where S. gordonii secretes orni
Externí odkaz:
https://doaj.org/article/ad0e14203c29454582399c456fd94b39
Autor:
Izabela Ciaston, Joanna Budziaszek, Dorota Satala, Barbara Potempa, Andrew Fuchs, Maria Rapala-Kozik, Danuta Mizgalska, Ewelina Dobosz, Richard J. Lamont, Jan Potempa, Joanna Koziel
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Porphyromonas gingivalis, a keystone pathogen in periodontitis (PD), produces cysteine proteases named gingipains (RgpA, RgpB, and Kgp), which strongly affect the host immune system. The range of action of gingipains is extended by their rel
Externí odkaz:
https://doaj.org/article/6f6b4ca4d2f04f4ca85c9ff93ed741ac
Autor:
Thaís Pacheco Santana, Eliane Gasparino, Angélica de Souza Khatlab, Claudson Oliveira Brito, Leandro Teixeira Barbosa, Susan J. Lamont, Ana Paula Del Vesco
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract A strategy to mitigate the negative effects of stress on animals is to enhance their ability to beneficially respond to stressful conditions. This study aimed to assess whether prenatal ambient temperature influences the response of Japanese
Externí odkaz:
https://doaj.org/article/cfc05d643e4d436991b33047900090f8
Autor:
Rommel J. Gestuveo, Jamie Royle, Claire L. Donald, Douglas J. Lamont, Edward C. Hutchinson, Andres Merits, Alain Kohl, Margus Varjak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Here the authors develop mosquito cell lines expressing Zika virus (ZIKV) capsid and perform proteomics experiments retrieving 157 protein interactors, of which they show 8 to act as pro-viral factors, showing the transitional endoplasmic reticulum 9
Externí odkaz:
https://doaj.org/article/cb2270c6864b4592bcfcd4b448736403
Autor:
Perot Saelao, Ying Wang, Ganrea Chanthavixay, Vivian Yu, Rodrigo A. Gallardo, Jack C. M. Dekkers, Susan J. Lamont, Terra Kelly, Huaijun Zhou
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Newcastle disease (ND) has a great impact on poultry health and welfare with its most virulent (velogenic) strain. In addition, issues exacerbated by the increase in global temperatures necessitates a greater understanding of the host immune
Externí odkaz:
https://doaj.org/article/495eab2fce1144118d034233e284b0e7
Autor:
Anees Rahman Cheratta, Faisal Thayyullathil, Simon A. Hawley, Fiona A. Ross, Abdelmajdid Atrih, Douglas J. Lamont, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Rachid Rezgui, Alex Gray, D. Grahame Hardie, Sehamuddin Galadari
Publikováno v:
Cell Reports, Vol 39, Iss 5, Pp 110761- (2022)
Summary: AMP-activated protein kinase (AMPK) coordinates energy homeostasis during metabolic and energy stress. We report that the catalytic subunit isoform AMPK-α1 (but not α2) is cleaved by caspase-3 at an early stage during induction of apoptosi
Externí odkaz:
https://doaj.org/article/dc89a458593d474787f73e8f3cb61c58