Zobrazeno 1 - 10
of 383
pro vyhledávání: '"J. Lamarche"'
Publikováno v:
Solid Earth, Vol 11, Pp 1163-1186 (2020)
Microporous carbonate rocks form important reservoirs with permeability variability depending on sedimentary, structural, and diagenetic factors. Carbonates are very sensitive to fluid–rock interactions that lead to secondary diagenetic processes l
Externí odkaz:
https://doaj.org/article/e2e29daa3a4247ed8fa2fba087ab24cb
Autor:
David C. Kombo, J. David Stepp, Sungtaek Lim, Bettina Elshorst, Yi Li, Laura Cato, Maysoun Shomali, David Fink, Matthew J. LaMarche
Publikováno v:
ACS Omega, Vol 9, Iss 26, Pp 28691-28706 (2024)
Externí odkaz:
https://doaj.org/article/6ede32189b7f4e20bb81e7600a038a41
Autor:
Ye Wang, Morvarid Mohseni, Angelo Grauel, Javier Estrada Diez, Wei Guan, Simon Liang, Jiyoung Elizabeth Choi, Minying Pu, Dongshu Chen, Tyler Laszewski, Stephanie Schwartz, Jane Gu, Leandra Mansur, Tyler Burks, Lauren Brodeur, Roberto Velazquez, Steve Kovats, Bhavesh Pant, Giri Buruzula, Emily Deng, Julie T. Chen, Farid Sari-Sarraf, Christina Dornelas, Malini Varadarajan, Haiyan Yu, Chen Liu, Joanne Lim, Huai-Xiang Hao, Xiaomo Jiang, Anthony Malamas, Matthew J. LaMarche, Felipe Correa Geyer, Margaret McLaughlin, Carlotta Costa, Joel Wagner, David Ruddy, Pushpa Jayaraman, Nathaniel D. Kirkpatrick, Pu Zhang, Oleg Iartchouk, Kimberly Aardalen, Viviana Cremasco, Glenn Dranoff, Jeffrey A. Engelman, Serena Silver, Hongyun Wang, William D. Hastings, Silvia Goldoni
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-23 (2021)
Abstract SHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune cell signaling. In this study, we discovered a novel immune modulatory function of SHP2. Targeting this protein with allosteric SHP2 inhibitors promoted a
Externí odkaz:
https://doaj.org/article/aeca1d5b6b344aeabcc21b726ae4f617
Autor:
Vidyasiri Vemulapalli, Lily A Chylek, Alison Erickson, Anamarija Pfeiffer, Khal-Hentz Gabriel, Jonathan LaRochelle, Kartik Subramanian, Ruili Cao, Kimberley Stegmaier, Morvarid Mohseni, Matthew J LaMarche, Michael G Acker, Peter K Sorger, Steven P Gygi, Stephen C Blacklow
Publikováno v:
eLife, Vol 10 (2021)
SHP2 is a protein tyrosine phosphatase that normally potentiates intracellular signaling by growth factors, antigen receptors, and some cytokines, yet is frequently mutated in human cancer. Here, we examine the role of SHP2 in the responses of breast
Externí odkaz:
https://doaj.org/article/653eeb5ad6e5454e9488ec62514b8bc7
Autor:
Jonathan R. LaRochelle, Michelle Fodor, Vidyasiri Vemulapalli, Morvarid Mohseni, Ping Wang, Travis Stams, Matthew J. LaMarche, Rajiv Chopra, Michael G. Acker, Stephen C. Blacklow
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Activating mutations of the non-receptor protein tyrosine phosphatase SHP2 can cause cancer. Here the authors present the crystal structure of SHP2E76K, the most frequent cancer-associated SHP2 mutation, which adopts an open-state structure and show
Externí odkaz:
https://doaj.org/article/d0fced2ac7bd48d8ba126a11fc5bed5f
Autor:
Matthew J. LaMarche
Publikováno v:
Journal of Medicinal Chemistry. 65:11478-11484
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1b472743c29ed417b8231d7e847dd6f
https://doi.org/10.1021/acs.jmedchem.2c01121
https://doi.org/10.1021/acs.jmedchem.2c01121
Autor:
Morvarid Mohseni, Silvia Goldoni, Jeffrey A. Engelman, Juliet Williams, Peter S. Hammerman, Tinya J. Abrams, Darrin D. Stuart, Giordano Caponigro, Serena J. Silver, Susan Moody, Matthew J. LaMarche, Ali Farsidjani, LeighAnn Alexander, Michael Fleming, Joanne Lim, Minying Pu, Matthew J. Meyer, Matthew Shirley, Bhavesh Pant, Hengyu Lu, Roberto Velazquez, Steven Kovats, Chen Liu, Hongyun Wang, Huai-Xiang Hao
Supplementary Table 4: List of cell lines evaluated for sensitivity to SHP099 (Tab 1) or an RTK-inhibitor (Tab 2) in 2D or 3D. Included is the lineage and the KRAS mutation status. Where data are blank, no viable data was available, or the cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f49ad0e25c2219927d12003d243a912
https://doi.org/10.1158/1535-7163.22505907
https://doi.org/10.1158/1535-7163.22505907
Autor:
Morvarid Mohseni, Silvia Goldoni, Jeffrey A. Engelman, Juliet Williams, Peter S. Hammerman, Tinya J. Abrams, Darrin D. Stuart, Giordano Caponigro, Serena J. Silver, Susan Moody, Matthew J. LaMarche, Ali Farsidjani, LeighAnn Alexander, Michael Fleming, Joanne Lim, Minying Pu, Matthew J. Meyer, Matthew Shirley, Bhavesh Pant, Hengyu Lu, Roberto Velazquez, Steven Kovats, Chen Liu, Hongyun Wang, Huai-Xiang Hao
In vivo efficacy of SHP099 (100 mg/kg, daily) in the KYSE-520 esophageal cancer cell line model. Data are plotted as the treatment mean {plus minus} s.e.m (n=7) ( (B-I) In vivo efficacy data for cell line models represented in Fig. 3E. SHP099 and tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e23a96a9d6967e72861ff793ea06ac6
https://doi.org/10.1158/1535-7163.22505931
https://doi.org/10.1158/1535-7163.22505931
Autor:
Morvarid Mohseni, Silvia Goldoni, Jeffrey A. Engelman, Juliet Williams, Peter S. Hammerman, Tinya J. Abrams, Darrin D. Stuart, Giordano Caponigro, Serena J. Silver, Susan Moody, Matthew J. LaMarche, Ali Farsidjani, LeighAnn Alexander, Michael Fleming, Joanne Lim, Minying Pu, Matthew J. Meyer, Matthew Shirley, Bhavesh Pant, Hengyu Lu, Roberto Velazquez, Steven Kovats, Chen Liu, Hongyun Wang, Huai-Xiang Hao
Supplementary Material and Methods. File contains the following: Transcriptome sequencing and analysis, Soft agar assay, 2D and 3D Cell proliferation screen and compound characterization information.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d0866bef518d87af5ce97aa1cbfb0d
https://doi.org/10.1158/1535-7163.22505919.v1
https://doi.org/10.1158/1535-7163.22505919.v1
Autor:
Huai-Xiang Hao, Giordano Caponigro, Morvarid Mohseni, Tinya J. Abrams, Peter S. Hammerman, Juliet A. Williams, Jeffrey A. Engelman, Matthew J. LaMarche, Susan E. Moody, Matthew J. Meyer, Hui Gao, Karrie Wong, William D. Hastings, Silvia Goldoni, Ye Wang, Scott Delach, Colleen Kowal, Guizhi Yang, Xiamei Zhang, Alice Loo, Hongyun Wang, Hengyu Lu, Chen Liu
CSF1R-driven SHP2-dependent MAPK signaling in GDM-1 cells and SHP2 dependency of the viability in M-CSF-stimulated monocytes in the T cell co-culture assay, and the in vivo combination benefit in suppressing tumor associated macrophage by anti-PD-1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06731a1fc427831477507d6aebca12e0
https://doi.org/10.1158/1078-0432.22478133
https://doi.org/10.1158/1078-0432.22478133