Zobrazeno 1 - 10
of 297
pro vyhledávání: '"J. LaRocca"'
Publikováno v:
The Cryosphere, Vol 18, Pp 4633-4644 (2024)
Tropical glaciers in the central Andes are vital water resources and crucial climate indicators, currently undergoing rapid retreat. However, understanding their vulnerability to the combined effects of persistent warming, the El Niño and La Niña c
Externí odkaz:
https://doaj.org/article/a343b6bbaf5e479183e4426fa97ddf3c
Publikováno v:
The Cryosphere, Vol 18, Pp 3591-3611 (2024)
The number of Arctic glaciers with direct, long-term measurements of mass balance is limited. Here we used satellite-based observations of the glacier snowline altitude (SLA), the location of the transition between snow cover and ice late in the summ
Externí odkaz:
https://doaj.org/article/2520b24e147545daa2bc77bbd91973cc
Autor:
Devin Wahl, Sydney J. Risen, Shelby C. Osburn, Tobias Emge, Sadhana Sharma, Vincenzo S. Gilberto, Anushree Chatterjee, Prashant Nagpal, Julie A. Moreno, Thomas J. LaRocca
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer’s disease, which is characterized by the aggregation of pathological tau. One major driver of both age- and tau-asso
Externí odkaz:
https://doaj.org/article/5605af35a84d4c0f8db032124aca9f4d
Publikováno v:
Experimental Gerontology, Vol 192, Iss , Pp 112458- (2024)
Reducing neuroinflammation, a key contributor to brain aging and neurodegenerative diseases, is a promising strategy for improving cognitive function in these settings. The FDA-approved nucleoside reverse transcriptase inhibitor 3TC (Lamivudine) has
Externí odkaz:
https://doaj.org/article/791b80b31cb4467192ca2845385f25df
Autor:
Christopher J. LaRocca, Julia Davydova
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 2, Pp 200811- (2024)
Externí odkaz:
https://doaj.org/article/a85d40663dc448eeb48000aebd73bba5
Autor:
Sacha Robert, Natasha Ivelisse Roman Ortiz, Christopher J. LaRocca, Julie Hanson Ostrander, Julia Davydova
Publikováno v:
Viruses, Vol 16, Iss 4, p 567 (2024)
Adjuvant systemic therapies effectively reduce the risk of breast cancer recurrence and metastasis, but therapy resistance can develop in some patients due to breast cancer stem cells (BCSCs). Oncolytic adenovirus (OAd) represents a promising therape
Externí odkaz:
https://doaj.org/article/e248c0f1cfbc42688c816e365679f650
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Neuroinflammation is a central mechanism of brain aging and Alzheimer’s disease (AD), but the exact causes of age- and AD-related neuroinflammation are incompletely understood. One potential modulator of neuroinflammation is the enzyme adenosine de
Externí odkaz:
https://doaj.org/article/9750a179d96f4dd5867b59733a106792
Autor:
L. J. Larocca, Y. Axford
Publikováno v:
Climate of the Past, Vol 18, Pp 579-606 (2022)
The recent retreat of nearly all glaciers and ice caps (GICs) located in Arctic regions is one of the most clear and visible signs of ongoing climate change. This paper synthesizes published records of Holocene GIC fluctuations from lake archives, pl
Externí odkaz:
https://doaj.org/article/a525f6e031cd4b84b61532354a21a139
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 44-45 (2023)
Externí odkaz:
https://doaj.org/article/bb7fe7521be34f138c0e96575ded8002
Autor:
Christopher J. LaRocca, Kari L. Jacobsen, Kazuho Inoko, Stanislav O. Zakharkin, Masato Yamamoto, Julia Davydova
Publikováno v:
Viruses, Vol 15, Iss 7, p 1495 (2023)
There have been numerous advances in gene therapy and oncolytic virotherapy in recent years, especially with respect to cutting-edge animal models to test these novel therapeutics. With all of these advances, it is important to understand the biosafe
Externí odkaz:
https://doaj.org/article/f76a5b134f8345fc81f8e1e8a77b38a9