Zobrazeno 1 - 10
of 182
pro vyhledávání: '"J. La Clair"'
Autor:
Mária Džunková, James J. La Clair, Tomáš Tyml, Devin Doud, Frederik Schulz, Samuel Piquer-Esteban, Dafne Porcel Sanchis, Andrew Osborn, David Robinson, Katherine B. Louie, Ben P. Bowen, Robert M. Bowers, Janey Lee, Vicente Arnau, Wladimiro Díaz-Villanueva, Ramunas Stepanauskas, Terrence Gosliner, Shailesh V. Date, Trent R. Northen, Jan-Fang Cheng, Michael D. Burkart, Tanja Woyke
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-24 (2023)
Abstract Background Nudibranchs comprise a group of > 6000 marine soft-bodied mollusk species known to use secondary metabolites (natural products) for chemical defense. The full diversity of these metabolites and whether symbiotic microbes are respo
Externí odkaz:
https://doaj.org/article/d885a6b36ed6498aa727710bc46feac4
Publikováno v:
Marine Drugs, Vol 21, Iss 2, p 56 (2023)
As one of the first families of marine natural products to undergo clinical trials, the didemnin depsipeptides have played a significant role in inspiring the discovery of marine drugs. Originally developed as anticancer therapeutics, the recent re-e
Externí odkaz:
https://doaj.org/article/ef827ce5676c4de0a82d59de9de787c0
Autor:
Jeffrey T. Mindrebo, Ashay Patel, Woojoo E. Kim, Tony D. Davis, Aochiu Chen, Thomas G. Bartholow, James J. La Clair, J. Andrew McCammon, Joseph P. Noel, Michael D. Burkart
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The formation of C-C bonds in fatty acid and polyketide biosynthesis depends on β-ketoacyl-acyl carrier protein (ACP) synthases (KSs). Here, the authors present structures of E.coli KSs bound to substrate mimetic bearing ACPs, providing insights int
Externí odkaz:
https://doaj.org/article/8b2f324577e8467b8bb69a969b0ffd83
Autor:
Warren C. Chan, Kelsey A. Trieger, James J. La Clair, Catriona H. M. Jamieson, Michael D. Burkart
Publikováno v:
Journal of Medicinal Chemistry. 66:6577-6590
Autor:
Amanda S. Hirata, James J. La Clair, Paula C. Jimenez, Leticia Veras Costa-Lotufo, William Fenical
Publikováno v:
Marine Drugs, Vol 20, Iss 5, p 301 (2022)
The bioactive natural product seriniquinone was discovered as a potential melanoma drug, which was produced by the as-yet-undescribed marine bacterium of the rare genus Serinicoccus. As part of a long-term research program aimed at the discovery of n
Externí odkaz:
https://doaj.org/article/083a8b8867334737a50b6bdd51c4f162
Autor:
Amanda S. Hirata, Paula Rezende-Teixeira, João Agostinho Machado-Neto, Paula C. Jimenez, James J. La Clair, William Fenical, Leticia V. Costa-Lotufo
Publikováno v:
Molecules, Vol 26, Iss 23, p 7362 (2021)
Isolated from the marine bacteria Serinicoccus sp., seriniquinone (SQ1) has been characterized by its selective activity in melanoma cell lines marked by its modulation of human dermcidin and induction of autophagy and apoptosis. While an active lead
Externí odkaz:
https://doaj.org/article/1232328600ab494ab287304dcff5d3b4
Autor:
James J. La Clair
Publikováno v:
Molecules, Vol 26, Iss 24, p 7649 (2021)
Understanding our oceans and their marine ecosystems has enabled the development of sustainable systems for mariculture. While the bulk of studies to date have focused on the production of food, its remarkable expanse has inspired the translation of
Externí odkaz:
https://doaj.org/article/92f24984a52c4e8885ba6f0e457b63d5
Autor:
Inge van der Werf, Phoebe K. Mondala, S. Kathleen Steel, Larisa Balaian, Luisa Ladel, Cayla N. Mason, Raymond H. Diep, Jessica Pham, Jacqueline Cloos, Gertjan J.L. Kaspers, Warren C. Chan, Adam Mark, James J. La Clair, Peggy Wentworth, Kathleen M. Fisch, Leslie A. Crews, Thomas C. Whisenant, Michael D. Burkart, Mary E. Donohoe, Catriona H.M. Jamieson
Publikováno v:
Cell reports. Medicine, vol 4, iss 3
Cell reports. Medicine, 4(3):100962. Cell Press
Cell Reports Medicine, 4(3):100962. Cell Press
van der Werf, I, Mondala, P K, Steel, S K, Balaian, L, Ladel, L, Mason, C N, Diep, R H, Pham, J, Cloos, J, Kaspers, G J L, Chan, W C, Mark, A, la Clair, J J, Wentworth, P, Fisch, K M, Crews, L A, Whisenant, T C, Burkart, M D, Donohoe, M E & Jamieson, C H M 2023, ' Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells ', Cell reports. Medicine, vol. 4, no. 3, 100962, pp. 100962 . https://doi.org/10.1016/j.xcrm.2023.100962, https://doi.org/10.1016/j.xcrm.2023.100962
Cell reports. Medicine, 4(3):100962. Cell Press
Cell Reports Medicine, 4(3):100962. Cell Press
van der Werf, I, Mondala, P K, Steel, S K, Balaian, L, Ladel, L, Mason, C N, Diep, R H, Pham, J, Cloos, J, Kaspers, G J L, Chan, W C, Mark, A, la Clair, J J, Wentworth, P, Fisch, K M, Crews, L A, Whisenant, T C, Burkart, M D, Donohoe, M E & Jamieson, C H M 2023, ' Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells ', Cell reports. Medicine, vol. 4, no. 3, 100962, pp. 100962 . https://doi.org/10.1016/j.xcrm.2023.100962, https://doi.org/10.1016/j.xcrm.2023.100962
Pediatric acute myeloid leukemia (pAML) is typified by high relapse rates and a relative paucity of somatic DNA mutations. Although seminal studies show that splicing factor mutations and mis-splicing fuel therapy-resistant leukemia stem cell (LSC) g
Publikováno v:
RSC Advances. 12:6947-6950
The tandem addition of an amine and a thiol to an aromatic dialdehyde engages a selective three-component assembly of a fluorescent isoindole. While an attractive approach for diversity-based fluorophore discovery, isoindoles are typically unstable a
Autor:
Nhan T. Pham, Joana Alves, Fiona A. Sargison, Reiko Cullum, Jan Wildenhain, William Fenical, Mark S. Butler, David A. Mead, Brendan M. Duggan, J. Ross Fitzgerald, James J. La Clair, Manfred Auer
Antimicrobial resistance has emerged as an urgent global public health threat, and development of novel therapeutics for treating infections caused by multi-drug resistant bacteria is urgent.Staphylococcus aureusis a major human and animal pathogen,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03f75102ea39e05cdde7ce4b15606bdb
https://doi.org/10.1101/2022.12.04.519019
https://doi.org/10.1101/2022.12.04.519019