Zobrazeno 1 - 10
of 15
pro vyhledávání: '"J. L. Yakel"'
Autor:
J L Yakel, Meyer B. Jackson
Publikováno v:
Annual Review of Physiology. 57:447-468
Autor:
S, Jones, J L, Yakel
Publikováno v:
Methods in molecular medicine. 22
Glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). Glutamate binds to and activates receptors coupled to both ligand-gated ion channels (ionotropic) and G proteins (metabotropic). The ionotropic glutamate receptor
Publikováno v:
The Journal of physiology. 586(5)
The substantia nigra pars reticulata (SNr) is the primary output nucleus for the basal ganglia (BG) in the rat. The SNr is reciprocally connected with the pedunculopontine tegmental nucleus (PPN) in the brainstem, which provides cholinergic innervati
Publikováno v:
Brain Research. 533:46-52
The 5-HT3 receptor is unusual among receptors for biogenic amines in that it is directly coupled to an ion channel that is highly permeable to Na+ and K+. We have studied the permeation properties of this channel in order to achieve a more detailed u
Autor:
J. L. Yakel
Publikováno v:
Pharmacology of Ionic Channel Function: Activators and Inhibitors ISBN: 9783642630309
The 5-HT3 receptor (5-HT3R) is a ligand-gated ion channel gated by the neurotransmitter serotonin (5-HT) and belonging to the superfamily of ligand-gated ion channels, a group that includes nicotinic acetylcholine (ACh), GABA, and glycine receptor ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b43ec28dc446310f05cd04f0a44057d
https://doi.org/10.1007/978-3-642-57083-4_21
https://doi.org/10.1007/978-3-642-57083-4_21
Autor:
S, Jones, J L, Yakel
Publikováno v:
Cell biochemistry and biophysics. 31(2)
Activation of 5-HT3 receptors expressed in Xenopus oocytes does not increase cytoplasmic Ca2+ levels
Autor:
P, Gilon, J L, Yakel
Publikováno v:
Receptorschannels. 3(2)
The wildtype 5-HT3 receptor was expressed in Xenopus oocytes from a cloned cDNA. Two-electrode voltage-clamp and fura-2 techniques were used simultaneously to monitor the current induced by the activation of the 5-HT3 receptor and the cytoplasmic Ca2
Publikováno v:
Molecular pharmacology. 43(2)
RNA was transcribed in vitro from a cDNA clone (RFL9) that encodes the rat adenosine A2b receptor. Xenopus oocytes that had been injected with this RNA several days earlier responded to adenosine (10 microM to 1 mM) with an inward current (45-750 nA)
Autor:
J. L. Yakel
Publikováno v:
Journal of neurophysiology. 65(6)
1. The modulation of the voltage-activated Ca2+ current by the neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFa) was investigated in dissociated central neurons from Helix aspersa using whole-cell voltage-clamp recording techniques. External Ba2+ was always u
Publikováno v:
The Journal of physiology. 436
1. Tight-seal voltage-clamp techniques were used to study the 5-HT3 receptor of differentiated NG108-15 cells. 2. The inward current caused by 5-HT was dependent on the 5-HT concentration: the apparent dissociation constant was 3.3 microM and the Hil