Zobrazeno 1 - 8
of 8
pro vyhledávání: '"J. L. Tomsig"'
Autor:
J. L. Tomsig, N. A. Talbot, Edward W. Kraegen, S. A. Patel, Gregory J. Cooney, Kyle L. Hoehn, Jonathan P. Whitehead, L. Sawbridge, Nigel Turner, Robert T. Lawrence, Mark E. Cleasby
Publikováno v:
Endocrinology
Adiponectin is an adipokine whose plasma levels are inversely related to degrees of insulin resistance (IR) or obesity. It enhances glucose disposal and mitochondrial substrate oxidation in skeletal muscle and its actions are mediated through binding
Autor:
Carl E. Creutz, J. L. Tomsig
Publikováno v:
Cellular and Molecular Life Sciences (CMLS). 59:1467-1477
The copines are a novel family of ubiquitous Ca(2+)-dependent, phospholipid-binding proteins. They contain two Ca(2+)- and phospholipid-binding domains known as 'C2 domains' present in proteins such as protein kinase C, phospholipase C and synaptotag
Autor:
Janusz B. Suszkiw, J. L. Tomsig
Publikováno v:
American Journal of Physiology-Cell Physiology. 265:C1630-C1636
The intracellular mechanism of Pb(2+)-induced release of norepinephrine (NE) was investigated in comparison with Ca2+ in bovine chromaffin cells permeabilized with staphylococcal alpha-toxin. Pb2+ activated NE release at considerably lower concentrat
Publikováno v:
Toxicology and applied pharmacology. 156(1)
Protein kinase C has been implicated as a cellular target for Pb2+ toxicity. We have previously proposed that Pb2+ modulates PKC activity by interacting with multiple sites within the enzyme. In order to further characterize the Pb-PKC interactions w
Autor:
J. L. Tomsig, Janusz B. Suszkiw
Publikováno v:
Journal of neurochemistry. 64(6)
We investigated the interaction between Pb 2+ and protein kinase C (PKC) in the Pb 2+ -induced release of norepinephrine (NE) from permeabilized adrenal chromaffin cells. Our analysis of endogenous PKC activity in permeabilized cells suggests that Pb
Publikováno v:
Brain research. 568(1-2)
High levels of tissue lactate exacerbate tissue damage that results from cerebral ischemia and reperfusion injury that follows. Post-ischemic treatment with dichloroacetate (DCA) facilitates a decrease in lactate in the central nervous system (CNS) o
Autor:
J. L. Tomsig, Janusz B. Suszkiw
Publikováno v:
The American journal of physiology. 259(5 Pt 1)
The effect of Pb2+ on catecholamine release was studied in isolated intact and permeabilized bovine chromaffin cells. Fura-2 was used to monitor intracellular Pb2+. A characterization of Pb2(+)-fura-2 interactions in solutions simulating intracellula
Autor:
A. Pellegrino de Iraldi, J. L. Tomsig
Publikováno v:
Histochemistry. 87(1)
Rat pineal nerve endings contain a population of small and of large synaptic vesicles that are either electron lucent or have electron-dense cores. It has been reported that their osmiophilia is eliminated when collidine buffer is used in the fixatio