Zobrazeno 1 - 10 of 135 pro vyhledávání: '"J. L. Schardein"'
1
REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF (±)-4-DIETHYLAMINO-1, 1-DIMETHYLBUT-2-YN-1-YL 2-CYCLOHEXYL-2-HYDROXY-2-PHENYLACETATE MONOHYDROCHLORIDE MONOHYDRATE(NS-21), A NOVEL DRUG FOR URINARY FREQUENCY AND INCONTINENCE (2) Teratogenicity Study in Rats by Oral Administration
Autor: J L, Schardein, R G, York, H, Ninomiya, M, Watanabe, N, Sumi
Publikováno v: The Journal of Toxicological Sciences. 22:213-228
A study of teratogenicity and developmental toxicity of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a new drug for the treatment of urinary frequency and incontinence, w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dec1ab1e87cb1d0c8d4a455fb493666
https://doi.org/10.2131/jts.22.supplementi_213
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2
Behavioral Testing in the Context of Reproductive and Developmental Toxicity Screening in the West
Autor: W. P. Weisenburger, J. L. Schardein, R. G. York
Publikováno v: Congenital Anomalies. 32:15-29
Methods for assessing animal neurobehavior following prenatal/perinatal exposures have been in use for almost 20 years and screening tests incorporating them are regulated in three settings: in Japanese Segment II and III studies on drugs, European (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08d9949f8ba75e245594d0adabd1a872
https://doi.org/10.1111/j.1741-4520.1992.tb00777.x
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3
A two-generation reproduction study in rats receiving diets containing hexamethylenediamine
Autor: R D, Short, F R, Johannsen, J L, Schardein
Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 16(3)
Rats received diets containing average daily doses of 0, 50, 150, and 500 mg/kg/day of hexamethylenediamine over two generations. Although no treatment-related mortality was observed in any of the groups, the weight gain of adults and pups was slight
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::207e02d52716940963da8add61e06345
https://pubmed.ncbi.nlm.nih.gov/1855621
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4
Inhalation developmental toxicity study of propylene oxide in Fischer 344 rats*1
Autor: S. B. Harris, J. L. Schardein, C. E. Ulrich, S. A. Ridlon
Publikováno v: Fundamental and Applied Toxicology. 13:323-331
The developmental toxicity potential of propylene oxide (PO) was evaluated in Fischer 344 rats following inhalation exposure. Four groups of 25 mated female rats were exposed to 0, 100, 300, and 500 ppm of PO for 6 hr per day on Gestation Days 6 thro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c10859373715963642529c628240db9
https://doi.org/10.1016/0272-0590(89)90268-6
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5
Fertility and teratogenic studies of diethylene glycol monobutyl ether in rats and rabbits*1
Autor: W. B. Gibson, J. L. Schardein, D. W. Briggs, J. H. Benedict, G. A. Nolen
Publikováno v: Fundamental and Applied Toxicology. 5:1137-1143
The solvent, diethylene glycol monobutyl ether (DGBE), was dosed orally at 0, 250, 500, or 1000 mg/kg/day to male rats for 60 days prior to mating and to females from 14 days prior to mating until sacrificed on Day 13 or the weaning of the offspring.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d21ea93c787b815c2f261fef60890501
https://doi.org/10.1016/0272-0590(85)90150-2
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9
Inhalation teratology studies of n-butyl mercaptan in rats and mice
Autor: C E Ulrich, J A Seckar, J L Schardein, W C Thomas, C J Kirwin, J T Johnson, D R Klonne
Publikováno v: Fundamental and Applied Toxicology. 8:170-178
n-Butyl mercaptan (n-BM) is used as a solvent and a chemical intermediate. Pregnant Charles River CD-1 mice and COBS CD rats were randomly assigned to a control group and to three n-BM-exposed groups of 25 rats and 25 mice each. The animals were expo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2086acf50e75556268c4b7c9b9d1953
https://doi.org/10.1016/0272-0590(87)90115-1
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