Zobrazeno 1 - 10
of 33
pro vyhledávání: '"J. L. Meek"'
Autor:
Charles J. Eyermann, Lee T. Bacheler, Francis J. Woerner, W. F. Daneker, C.-H. Chang, Susan Erickson-Viitanen, Patrick Y.S. Lam, J. L. Meek, M. M. Rayner, M.C. Schadt, H.-W. Man, David A. Jackson, Hodge Carl Nicholas, Joseph C. Calabrese, Prabhakar K. Jadhav
Publikováno v:
Journal of Medicinal Chemistry. 41:1446-1455
Comparison of the high-resolution X-ray structures of the native HIV-1 protease and its complexes with the inhibitors suggested that the enzyme flaps are flexible. The movement at the tip of the flaps could be as large as 7 A. On the basis of this ob
Autor:
Gilbert N. Lam, Ronald M. Klabe, A. Y. Hollis, Wendell Wilkie Wilkerson, Susan Erickson-Viitanen, Lee T. Bacheler, J. L. Meek, Beverly C. Cordova, W. W. Cheatham
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:3027-3032
Synthetic efforts to overcome the metabolic oxidative degradation of the HIV protease inhibitory cyclic urea DMP323 , a benzyl alcohol, have led to the discovery of a tertiary carbinol with superior affinity for the viral protease and more potent inh
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:1628-1634
DMP 323 is a potent inhibitor of the protease of human immunodeficiency virus (HIV), with antiviral activity against both HIV type 1 and HIV type 2. This compound is representative of a class of small, novel, nonpeptide cyclic urea inhibitors of HIV
Autor:
J. L. Meek, C. Dai
Publikováno v:
Computer Methods in Applied Mechanics and Engineering. 102:15-27
The present paper has adopted the Mindlin solution for the plane strain case and then applied this to use a two-dimensional boundary element formulation using direct integration for a constant stress element. The results are compared with those of th
Autor:
Beverly C. Cordova, Lee T. Bacheler, Susan Erickson-Viitanen, J. L. Meek, Wendell Wilkie Wilkerson, Gilbert N. Lam, W. W. Cheatham, A. Y. Hollis, Ronald M. Klabe
Publikováno v:
ChemInform. 27
Synthetic efforts to overcome the metabolic oxidative degradation of the HIV protease inhibitory cyclic urea DMP323 , a benzyl alcohol, have led to the discovery of a tertiary carbinol with superior affinity for the viral protease and more potent inh
Autor:
J. L. Meek, C. Dai
Publikováno v:
International Journal for Numerical and Analytical Methods in Geomechanics. 16:655-667
In this paper, we have deduced the integration solution of the Melan problem (concentrated force at a point in the infinite half‐plane) over a line segment directly from the two‐dimensional result by the complex variable function method. The BEM
Autor:
W. J. Lin, J. L. Meek
Publikováno v:
Journal of Structural Engineering. 116:1473-1490
In this paper, the effect of plastic area deformation after local yielding of thin‐walled beam‐columns is studied. Beyond the yield point of the material in the beam‐columns, the effective stress‐strain curve is determined by experiment. The
Publikováno v:
Biochemistry. 37(24)
Resistance of HIV-1 to protease inhibitors has been associated with changes at residues Val82 and Ile84 of HIV-1 protease (HIV PR). Using both an enzyme assay with a peptide substrate and a cell-based infectivity assay, we examined the correlation be
Publikováno v:
Clinical Chemistry. 29:624-628
We describe a liquid-chromatographic method for simultaneous quantification of haloperidol and its reduced metabolite in plasma and serum. Haloperidol and reduced haloperidol are concentrated from blood samples by liquid/liquid extraction into a hexa
Autor:
S. Loganathan, J. L. Meek
Publikováno v:
Computer Methods in Applied Mechanics and Engineering. 72:57-75
The current research is mainly concerned with the geometrically nonlinear static analysis of three-dimensional space-frame structures. The elastic analysis of frame structures by means of the finite element method in the post-buckling range inevitabl