Zobrazeno 1 - 10
of 27
pro vyhledávání: '"J. L. Masferrer"'
Publikováno v:
Inflammation Research. 58:109-117
To determine the effect of combinations of cyclooxygenase (COX) inhibitors and inhibitors of leukotriene (LT) syntheses on collagen induced arthritis (CIA) in mice. The CIA model was evaluated for the presence of eicosanoids in the paw tissue. Severa
Publikováno v:
Scandinavian Journal of Gastroenterology. 36:865-869
Autor:
B. M. Woerner, J. L. Masferrer, Demaretta S. Rush, Robert A. Soslow, Alane T. Koki, K. Nasir Khan, Andrew J. Dannenberg
Publikováno v:
Cancer. 89:2637-2645
BACKGROUND The cyclooxygenase (COX) enzyme catalyzes the formation of prostaglandins, which can affect cell proliferation and alter the response of the immune system to malignant cells. The inducible form of COX, COX-2, has been shown to be important
Autor:
Robert A. Soslow, Karen Seibert, B. M. Woerner, Andrew J. Dannenberg, Alane T. Koki, J. L. Masferrer, J. L. Harmon, N. K. Khan
Publikováno v:
Prostaglandins, leukotrienes, and essential fatty acids. 66(1)
Increased prostaglandins (PGs) are associated with many inflammatory pathophysiological conditions; and are synthesized from arachidonic acid by either of 2 enzymes, cyclooxygenase-1 (COX-1) or -2 (COX-2). Recent epidemiologic, expression, and pharma
Publikováno v:
Anticancer research. 21(5)
Recent chemopreventive studies in our laboratories showed that the COX-2 inhibitor, celecoxib, inhibited the induction of mammary cancer by 7,12-dimethylbenz(a)anthracene (DMBA). In this study, we examined the relative chemopreventive effect of varyi
Publikováno v:
Scandinavian journal of gastroenterology. 36(8)
The cyclooxygenase (COX) enzymes exist in two related but unique isoforms (COX-1 and COX-2) and catalyze the formation of prostaglandins (PGs). COX-1 is constitutively expressed, and is responsible for the synthesis of PGs necessary for gastroprotect
Autor:
S, Kulkarni, J S, Rader, F, Zhang, H, Liapis, A T, Koki, J L, Masferrer, K, Subbaramaiah, A J, Dannenberg
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(2)
Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2) is an important target for preventing epithelial malignancies. Little is known, however, about the expression of COX-2 in gynecological malignancies. By immunoblot analysis, COX-2 was d
Autor:
C J, Grubbs, R A, Lubet, A T, Koki, K M, Leahy, J L, Masferrer, V E, Steele, G J, Kelloff, D L, Hill, K, Seibert
Publikováno v:
Cancer research. 60(20)
Epidemiological studies have shown that nonsteroidal anti-inflammatory drugs (NSAIDs) may have a role in the prevention of human cancers. A number of preclinical studies have also suggested that inhibition of cyclooxygenase (COX) with NSAIDs has an a
Autor:
K, Kishi, S, Petersen, C, Petersen, N, Hunter, K, Mason, J L, Masferrer, P J, Tofilon, L, Milas
Publikováno v:
Cancer research. 60(5)
Cyclooxygenase-2 (COX-2), an inducible isoform of cyclooxygenase, is overexpressed in many types of malignant tumors, where it mediates production of prostaglandins (PGs), which in turn may stimulate tumor growth and protect against damage by cytotox
Autor:
J L, Masferrer, K M, Leahy, A T, Koki, B S, Zweifel, S L, Settle, B M, Woerner, D A, Edwards, A G, Flickinger, R J, Moore, K, Seibert
Publikováno v:
Cancer research. 60(5)
We provide evidence that cyclooxygenase (COX)-2-derived prostaglandins contribute to tumor growth by inducing newly formed blood vessels (neoangiogenesis) that sustain tumor cell viability and growth. COX-2 is expressed within human tumor neovasculat