Výsledky vyhledávání - "J. L. Kinsella"

Proton dependence of the partial reactions of the sodium-proton exchanger in renal brush border membranes

Autor: Kinya Otsu, E Koh, J P Froehlich, J L Kinsella

Publikováno v: Journal of Biological Chemistry. 267:8089-8096

The pre-steady state time dependence of Na+ accumulation by the Na(+)-H+ exchanger in renal brush border membrane vesicles was investigated at 0 degree C by a manual mixing technique using amiloride to quench the reaction. Dilution of acid-loaded (pH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0a6066660c55edb70d9070305b70aab
https://doi.org/10.1016/s0021-9258(18)42411-8

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Stimulation by thyroid hormone of Na+-H+ exchange activity in cultured opossum kidney cells

Autor: K. Yonemura, J. L. Kinsella, B. Sacktor, L. Cheng

Publikováno v: American Journal of Physiology-Renal Physiology. 258:F333-F338

Cultured opossum kidney (OK) cells were used to determine whether thyroid hormone has a direct stimulatory effect on Na(+)-H+ exchange activity in an intact cellular preparation. Na+ uptake or intracellular pH recovery was measured in confluent monol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9715532cd3d856a2af0a87674dab6660
https://doi.org/10.1152/ajprenal.1990.258.2.f333

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Na+/H+ exchanger: proton modifier site regulation of activity

Autor: J L, Kinsella, P, Heller, J P, Froehlich

Publikováno v: Biochemistry and cell biology = Biochimie et biologie cellulaire. 76(5)

The Na+/H+ exchangers (NHE1-6) are integral plasma membrane proteins that catalyze the exchange of extracellular Na+ for intracellular H+. In addition to Na+ and H+ transport sites, NHE has an intracellular allosteric H+ modifier site that increases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7afdbc002d125fe82feea77bf9d982b
https://pubmed.ncbi.nlm.nih.gov/10353707

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Sodium dependence of the Na(+)-H+ exchanger in the pre-steady state. Implications for the exchange mechanism

Autor: K, Otsu, J L, Kinsella, P, Heller, J P, Froehlich

Publikováno v: The Journal of biological chemistry. 268(5)

The pre-steady state time course of amiloride-sensitive Na+o uptake by the Na(+)-H+ exchanger in renal brush border membrane vesicles (BBMV) exhibits a burst phase at 0 degrees C which corresponds to the initial turnover of the exchanger (Otsu, K., K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d154d2e48ea997871f529b27f745b275
https://pubmed.ncbi.nlm.nih.gov/8381420

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Scatter factor (hepatocyte growth factor) is a potent angiogenesis factor in vivo

Autor: E M, Rosen, D S, Grant, H K, Kleinman, I D, Goldberg, M M, Bhargava, B J, Nickoloff, J L, Kinsella, P, Polverini

Publikováno v: Symposia of the Society for Experimental Biology. 47

Scatter factor (SF), a fibroblast-derived cytokine characterized by its ability to convert non-motile epithelial cells to a motile fibroblast-like phenotype, is identical to hepatocyte growth factor (HGF), a broad-spectrum mitogen. SF is a heterodime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ff0b389cfc92cf0d9216f6971ba3a08
https://pubmed.ncbi.nlm.nih.gov/8165567

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Age-associated changes in ammoniagenesis in isolated rat renal tubule segments

Autor: H. Yamada, B. Sacktor, J. L. Kinsella

Publikováno v: The American journal of physiology. 262(4 Pt 2)

We investigated renal ammoniagenesis in isolated nephron segments from control and acidotic senescent and young adult rats. When young (6 mo) and senescent (24 mo) control groups were compared, there was no significant difference in glutamine-depende

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c198ad039ec94b858c2759f25da5ef
https://pubmed.ncbi.nlm.nih.gov/1566873

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Action of glucocorticoids on proximal tubule transport systems

Autor: J L, Kinsella

Publikováno v: Seminars in nephrology. 10(4)

A number of transport systems in the proximal tubule now have been shown to change activity in response to glucocorticoids. Two of them, the Na(+)-H+ exchanger and the Na(+)-dependent phosphate transporter, are apparently directly regulated by specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2f82898a45e3f3fe0df8d25242a0686
https://pubmed.ncbi.nlm.nih.gov/2166325

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Inhibition of Na+-H+ exchange by N,N'-dicyclohexylcarbodiimide in isolated rat renal brush border membrane vesicles

Autor: B Sacktor, J L Kinsella, N Wilkins, J Wehrle

Publikováno v: Journal of Biological Chemistry. 262:7092-7097

The inactivation of rat renal brush border membrane Na+-H+ exchange by the covalent carboxylate reagent N,N'-dicyclohexylcarbodiimide (DCCD) was studied by measuring 1 mM Na+ influx in the presence of a pH gradient (pHi = 5.5; pHo = 7.5) and H+ influ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cebbe38296bb45466e897db14a02acc
https://doi.org/10.1016/s0021-9258(18)48208-7

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Renal adaptation to metabolic acidosis in senescent rats

Autor: J. L. Kinsella, Rajendra Prasad, B. Sacktor

Publikováno v: American Journal of Physiology-Renal Physiology. 255:F1183-F1190

In this study, we compared results obtained in senescent rats with young rats given an equivalent acid load. We examined the renal changes by giving equivalent acid loads for 48 h to both 6- and 24-mo-old rats. The basal excretion of ammonium was the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff71644c33ac507e2046f3402dc2888
https://doi.org/10.1152/ajprenal.1988.255.6.f1183

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