Zobrazeno 1 - 10
of 108
pro vyhledávání: '"J. L. Jacobs"'
Publikováno v:
Phytobiomes Journal, Vol 3, Iss 3, Pp 224-234 (2019)
Corn is a staple feed and biofuel crop with a value close to $3.7 billion dollars for Michigan’s economy. Knowledge about distribution and abundance of seedling pathogens in Michigan corn fields is limited. Here we used a combination of culture-bas
Externí odkaz:
https://doaj.org/article/96dfe38243f445a4ac8f0a268d3d1faf
Autor:
Shiu Yeung Lam, Ruben van der Lugt, Aurora Cerutti, Zeliha Yalçin, Alexander M. Thouin, Marco Simonetta, Jacqueline J. L. Jacobs
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Appropriate repair of damaged DNA and the suppression of DNA damage responses at telomeres are essential to preserve genome stability. DNA damage response (DDR) signaling consists of cascades of kinase-driven phosphorylation events, fine-tun
Externí odkaz:
https://doaj.org/article/b74aa4e21a574c729c4054e113063d0e
Autor:
Zeliha Yalçin, Shiu Yeung Lam, Marieke H. Peuscher, Jaco van der Torre, Sha Zhu, Prasanna V. Iyengar, Daniel Salas-Lloret, Inge de Krijger, Nathalie Moatti, Ruben van der Lugt, Mattia Falcone, Aurora Cerutti, Onno B. Bleijerveld, Liesbeth Hoekman, Román González-Prieto, Jacqueline J. L. Jacobs
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Maintenance of genome integrity requires tight control of DNA damage response (DDR) signalling and repair, with phosphorylation and ubiquitination representing key elements. How these events are coordinated to achieve productive DNA repair r
Externí odkaz:
https://doaj.org/article/5904fb9cf15e4ea0bcf5f618e256368f
Autor:
Annemie M W J Schols, Anke H Maitland-van der Zee, Joop P van den Bergh, Sebastiaan Holverda, Esther J Nossent, Els J M Weersink, Marianne A van de Pol, Firdaus A A Mohamed Hoesein, Lisanne T Schuurman, Ivo van der Lee, Jelle M Blankestijn, Mahmoud I Abdel-Aziz, Nadia Baalbaki, Somayeh Bazdar, Inés Beekers, Rosanne J H C G Beijers, Lizan D Bloemsma, Merel E B Cornelissen, Debbie Gach, Laura Houweling, John J L Jacobs, Reneé Jonker, Paulien M A Linders, Lieke C E Noij, Daphne W Schaminee, Brigitte Sondermeijer, J J Miranda Geelhoed, Yolanda de Wit-van Wijck
Publikováno v:
BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)
Background Four months after SARS-CoV-2 infection, 22%–50% of COVID-19 patients still experience complaints. Long COVID is a heterogeneous disease and finding subtypes could aid in optimising and developing treatment for the individual patient.Meth
Externí odkaz:
https://doaj.org/article/08cab7016402442e9e9b869081c263bd
Autor:
Daria Shevtsova, Anam Ahmed, Iris W A Boot, Carmen Sanges, Michael Hudecek, John J L Jacobs, Simon Hort, Hubertus J M Vrijhoef
Publikováno v:
JMIR Human Factors, Vol 11, p e47031 (2024)
BackgroundArtificial intelligence (AI)–powered technologies are being increasingly used in almost all fields, including medicine. However, to successfully implement medical AI applications, ensuring trust and acceptance toward such technologies is
Externí odkaz:
https://doaj.org/article/dbd626d0294048c38dce54fea962e7ca
Autor:
Niklas Bäckel, Simon Hort, Tamás Kis, David F. Nettleton, Joseph R. Egan, John J. L. Jacobs, Dennis Grunert, Robert H. Schmitt
Publikováno v:
Frontiers in Molecular Medicine, Vol 3 (2023)
This paper discusses the challenges of producing CAR-T cells for cancer treatment and the potential for Artificial Intelligence (AI) for its improvement. CAR-T cell therapy was approved in 2018 as the first Advanced Therapy Medicinal Product (ATMP) f
Externí odkaz:
https://doaj.org/article/91bf0e4959f147c7939554fa0cf7814f
Autor:
Inés Paniagua, Zainab Tayeh, Mattia Falcone, Santiago Hernández Pérez, Aurora Cerutti, Jacqueline J. L. Jacobs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
MAD2L2 – as a member of the shieldin complex - counteracts resection during DNA repair. Here the authors demonstrate that MAD2L2 protects stalled replication forks from excessive resection, in a shieldin-independent and REV3L-dependent manner.
Externí odkaz:
https://doaj.org/article/a9b173c02d504a909a58c98740cb0626
Autor:
Inge de Krijger, Bastian Föhr, Santiago Hernández Pérez, Estelle Vincendeau, Judit Serrat, Alexander Marc Thouin, Vivek Susvirkar, Chloé Lescale, Inés Paniagua, Liesbeth Hoekman, Simranjeet Kaur, Maarten Altelaar, Ludovic Deriano, Alex C. Faesen, Jacqueline J. L. Jacobs
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
MAD2L2 — a member of the shieldin complex — is known to play important roles in DNA repair. Here the authors demonstrate how MAD2L2 dimerization mediated through SHLD2 participates in shieldin assembly and function.
Externí odkaz:
https://doaj.org/article/ff52d6b334fd4c1a8c8a1c74813d0adb
Autor:
Simon Hort, Laura Herbst, Niklas Bäckel, Frederik Erkens, Bastian Niessing, Maik Frye, Niels König, Ioannis Papantoniou, Michael Hudecek, John J. L. Jacobs, Robert H. Schmitt
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
CAR-T cell therapy is a promising treatment for acute leukemia and lymphoma. CAR-T cell therapies take a pioneering role in autologous gene therapy with three EMA-approved products. However, the chance of clinical success remains relatively low as th
Externí odkaz:
https://doaj.org/article/9bb8ea8db6534f5982f371b47e1dbc02
Autor:
M. E. Rogers, A. R. Lawson, K. Giri, Y. Williams, J. B. Garner, L. C. Marett, W. J. Wales, J. L. Jacobs
Publikováno v:
Animal Production Science. 62:736-742
Context The incidence of extreme heat events (prolonged temperatures above 35°C) is increasing in the northern Victorian dairying region in Australia. This increase is having a significant effect on the performance of perennial ryegrass, which has t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ad40cd1f5fe1ed9cf353893e8b00412
https://doi.org/10.1071/an21012
https://doi.org/10.1071/an21012