Zobrazeno 1 - 10
of 28
pro vyhledávání: '"J. L. Holton"'
Autor:
Niranjanan Nirmalananthan, Camilla N. Clark, A. Quaegebeur, J. L. Holton, A. D. MacKinnon, Anthony C Pereira, Tamas Revesz, Leslie R. Bridges
Publikováno v:
Neuropathology and Applied Neurobiology. 46:292-295
Publikováno v:
Veterinary Pathology. 35:53-63
Within 10 minutes of intraperitoneal injection of penitrem A (3 mg/kg), rats develop severe generalized tremors and ataxia that persist for up to 48 hours. These are accompanied by a three- to fourfold increase in cerebellar cortical blood flow. Mito
Publikováno v:
Neuropathology and Applied Neurobiology. 23:355-363
The curiously consistent localization of cerebellar cortical damage in chronic alcoholism is re-evaluated in the light of selective damage, with a similar topography in the cerebellar vermal region, in superficial siderosis in man and in experimental
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 29(7)
Cognitive impairment (CI) is an exclusion criterion for the diagnosis of multiple system atrophy (MSA), according to the second consensus statement. This view was recently challenged by patients with pathologically confirmed MSA who were reported to
Autor:
Helen, Ling, H, Ling, R, de Silva, L A, Massey, R, Courtney, G, Hondhamuni, N, Bajaj, J, Lowe, J L, Holton, A, Lees, T, Revesz
Publikováno v:
Neuropathology and Applied Neurobiology
Aims Since the first description of the classical presentation of progressive supranuclear palsy (PSP) in 1963, now known as Richardson's syndrome (PSP-RS), several distinct clinical syndromes have been associated with PSP-tau pathology. Like other n
Autor:
J. L. M. Hyam, David R. Garrod, Jonathan P. Clarke, Kevin K M Yue, Martyn A.J. Chidgey, T. Hashimoto, J. L. Holton
Publikováno v:
Europe PubMed Central
Desmocollins are cadherin-like glycoproteins involved in cell adhesion and plaque formation in desmosome junctions. Three distinct isoforms, the products of different genes, have been found in bovine tissues. We have reported previously that one of t
Publikováno v:
Neuropathology and applied neurobiology. 38(6)
Neuropathology has been the key to understanding the aetiology of many neurological disorders such as Alzheimer's disease, Parkinson's disease, frontotemporal degeneration and cerebellar ataxias. Dystonia shares many clinical features with these cond
Autor:
A, Li, R, Paudel, R, Johnson, R, Courtney, A J, Lees, J L, Holton, J, Hardy, T, Revesz, H, Houlden
Publikováno v:
Neuropathology and Applied Neurobiology
Aims: Mutations in the pantothenate kinase 2 gene (PANK2) are responsible for the most common type of neurodegeneration with brain iron accumulation (NBIA), known as pantothenate kinase-associated neurodegeneration (PKAN). Historically, NBIA is consi
Publikováno v:
Neuropathology and applied neurobiology. 38(1)
Multiple system atrophy (MSA) is an unrelenting, sporadic, adult-onset, neurodegenerative disease of unknown aetiology. Its clinically progressive course is characterized by a variable combination of parkinsonism, cerebellar ataxia and/or autonomic d
Autor:
S, Sharma, R, Bandopadhyay, T, Lashley, A E M, Renton, A E, Kingsbury, R, Kumaran, C, Kallis, C, Vilariño-Güell, S S, O'Sullivan, A J, Lees, T, Revesz, N W, Wood, J L, Holton
Publikováno v:
Neuropathology and applied neurobiology. 37(7)
Mutations in the gene encoding leucine-rich repeat kinase-2 (LRRK2) have been established as a common genetic cause of Parkinson's disease (PD). The distribution of LRRK2 mRNA and protein in the human brain has previously been described, although it