Zobrazeno 1 - 10
of 127
pro vyhledávání: '"J. L. Flippen-Anderson"'
Autor:
Anna K. Przybył, Shinichi Kodato, and Arthur E. Jacobson, Akihiro Hashimoto, Xinrong Tian, Joannes T. M. Linders, Kenner C. Rice, Jeffrey R. Deschamps, Clifford George, J. L. Flippen-Anderson
Publikováno v:
The Journal of Organic Chemistry. 69:5322-5327
The synthesis of the ortho- and para-e isomers in the oxide-bridged 5-phenylmorphan series of rigid tetracyclic compounds was accomplished via rac-5-(2-fluoro-5-nitrophenyl)-2-methyl-2-azabicyclo[3.3.1]nonan-9β-ol ((±)-10), an intermediate containi
Autor:
J. L. Flippen-Anderson, Aleksandra Misicka, Victor J. Hruby, Jeffrey R. Deschamps, Andrzej W. Lipkowski, Clifford George
Publikováno v:
The Journal of Peptide Research. 59:123-133
Biphalin is a dimeric opioid peptide, composed of two tetrapeptides connected 'tail-to-tail', that exhibits a high affinity for all three opioid receptor types (i.e. mu, delta and kappa). This study presents the X-ray crystal structure of biphalin su
Autor:
Ying Zhang, and Arthur E. Jacobson, Kenner C. Rice, David B. Joseph, Christina M. Dersch, Richard B. Rothman, J. L. Flippen-Anderson, Wayne D. Bowen
Publikováno v:
Journal of Medicinal Chemistry. 44:3937-3945
We have prepared azabicyclo[3.2.1] derivatives (C-3-substituted tropanes) that bind with high affinity to the dopamine transporter and inhibit dopamine reuptake. Within the series, 3-[2-[bis-(4-fluorophenyl)methoxy]ethylidene]-8-methyl-8-azabicyclo[3
Publikováno v:
Journal of the American Chemical Society. 119:9411-9416
The crystal structures of the ammonium, 1, lithium, 2, potassium, 3, and cesium, 4, salts of a new nitrogen oxy anion, N3O4-, have been determined. In 1 there are two interpenetrating three-dimensi...
Autor:
Richard B. Rothman, Peg Davis, Henry I. Yamamura, Yousuke Katsura, Karen Becketts, Heng Xu, J. L. Flippen-Anderson, Koichi Homma, Xiaoyan Zhang, Silvia N. Calderon, Eric J. Foltz, Kenner C. Rice, Frank Porreca
Publikováno v:
Journal of Medicinal Chemistry. 40:2936-2947
A series of N-alkyl- and N,N-dialkyl-4-[alpha-[(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl] benzyl]-benzamides were synthesized and evaluated for binding affinities at mu, delta, and kappa opioid receptor subtypes. Several compounds (2e,f,h,i,m) stron
Autor:
Frank Porreca, Edward J. Bilsky, J. L. Flippen-Anderson, Robert Horvath, Hiroshi Kayakiri, Kenner C. Rice, Silvia N. Calderon, L.E. Smith, Richard B. Rothman, Heng Xu, Peg Davis, Karen Becketts
Publikováno v:
Journal of Medicinal Chemistry. 40:695-704
The highly selective delta (δ) opioid receptor agonist SNC 80 [(+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide, (+)-21] and novel optically pure derivatives were synthesized from the enantiomers of
Publikováno v:
Journal of Peptide Science. 2:106-116
Autor:
Frank Porreca, Heng Xu, Kenner C. Rice, Peg Davis, Karen Becketts, Craig M. Bertha, Richard B. Rothman, J. L. Flippen-Anderson, Matthew R. Ellis
Publikováno v:
Journal of Medicinal Chemistry. 39:2081-2086
Derivatives of racemic and optically pure levorotatory 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]in dol-6-yl)phenols containing methoxy substituents in the C10', C9', and C8' positions (compounds 9-11, respectively) were synthes
Autor:
J. L. Flippen-Anderson, Allyn C. Howlett, Koichiro Yamada, Susan Jean Ward, M. A. Eissenstat, Kenner C. Rice, Johnson Mr
Publikováno v:
Journal of Medicinal Chemistry. 39:1967-1974
A series of (aminoalkyl)indole compounds, naphthalene analogs of pravadoline (1), has been shown to exhibit cannabinoid agonist activities such as antinociception in animals, inhibition of adenylate cyclase in brain membranes, and binding to the cann
Publikováno v:
Tetrahedron Letters. 45:1027-1029
Using a copper-catalyzed coupling reaction of amino acid and aryl halide, followed by intramolecular cyclization of N -aryl-1-hydroxyl-3-propylamines under the Swern’s condition as the key steps, ( S )-2-hydroxymethyl-1,2,3,4-tetrahydroquinoline wa