Výsledky vyhledávání - "J. L. Darlix"

Targeting the Assembly of the Human Immunodeficiency Virus Type I

Autor: J. L. Darlix, A. Cimarelli, Delphine Muriaux

Publikováno v: Current Pharmaceutical Design
Current Pharmaceutical Design, Bentham Science Publishers, 2004, 10 (30), pp.3725-3739. ⟨10.2174/1381612043382701⟩
Current Pharmaceutical Design, 2004, 10 (30), pp.3725-3739. ⟨10.2174/1381612043382701⟩

In the rush to develop anti-viral drugs against the human immunodeficiency virus type I (HIV-1), all the steps of the viral life cycle are potential targets of therapeutic intervention. In this review, we will explore the recent advances on strategie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b173bc04cf71084b85fadd457bd4214
https://doi.org/10.2174/1381612043382701

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Human immunodeficiency virus type 1 nucleocapsid protein specifically stimulates Mg2+-dependent DNA integration in vitro

Autor: Christian Auclair, Bernard P. Roques, J L Darlix, S C Batson, Jean-François Mouscadet, L Poljak, E Käs, H. De Rocquigny, S. Carteau

Publikováno v: Journal of Virology. 71:6225-6229

The integrase (IN) protein of the human immunodeficiency virus mediates integration of the viral DNA into the cellular genome. In vitro, this reaction can be mimicked by using purified recombinant IN and model DNA substrates. IN mediates two reaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245a368b9fc3ab33ce4a0a39d5fce1e9
https://doi.org/10.1128/jvi.71.8.6225-6229.1997

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Effect of mutations in the nucleocapsid protein (NCp7) upon Pr160(gag-pol) and tRNA(Lys) incorporation into human immunodeficiency virus type 1

Autor: Lawrence Kleiman, Jing Wang, J L Darlix, Mark A. Wainberg, Ahmad Khorchid, Yue Huang, Michael A. Parniak

Publikováno v: Journal of Virology. 71:4378-4384

COS-7 cells were transfected with DNAs containing mutations in the NCp7 sequences of human immunodeficiency virus. Selective incorporation into the virus of tRNA(Lys) was measured by two-dimensional polyacrylamide gel electrophoresis, and Pr160(gag-p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1622e4b7e2344487841aeaf030454bb0
https://doi.org/10.1128/jvi.71.6.4378-4384.1997

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Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site

Autor: H de Rocquigny, Lawrence Kleiman, Yudong Quan, J L Darlix, Mark A. Wainberg, B P Roques, Xiaoyu Li, B D Preston, Michael A. Parniak, Zhuo Li, Eric J. Arts

Publikováno v: Journal of Virology. 70:4996-5004

Retroviral reverse transcription starts near the 5' end of unspliced viral RNA at a sequence called the primer binding site (PBS), where the tRNA primer anneals to the RNA template for initiation of DNA synthesis. We have investigated the roles of NC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c2ccb6cc93e97ac10b5cdaa83a41b2
https://doi.org/10.1128/jvi.70.8.4996-5004.1996

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1H NMR structure and biological studies of the His23 .fwdarw. Cys mutant nucleocapsid protein of HIV-1 indicate that the conformation of the first zinc finger is critical for virus infectivity

Autor: H, Déméné, C Z, Dong, M, Ottmann, M C, Rouyez, N, Jullian, N, Morellet, Y, Mely, J L, Darlix, M C, Fournié-Zaluski, S, Saragosti

Publikováno v: Biochemistry. 33:11707-11716

The nucleocapsid protein NCp7 of human immunodeficiency virus type 1 (HIV-1), which has key functions in the virus life cycle, possesses two zinc fingers of the CX2CX4HX4C type characterized by three successive loops containing a tetrahedrally coordi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae9e2c2cba4b7ca31ce6b2dfde1c1da
https://doi.org/10.1021/bi00205a006

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Purification and characterization of recombinant equine infectious anemia virus reverse transcriptase

Autor: Robert C. Kalayjian, N. J. Richter, M. Panin, S. F. J. Le Grice, Susan Payne, J.-L. Darlix, G. Keith

Publikováno v: Journal of Virology. 65:7004-7007

A 1.67-kb segment of the equine infectious anemia virus pol gene, encoding a 66-kDa reverse transcriptase (RT), was cloned and expressed in Escherichia coli. Recombinant RT, purified by a combination of metal chelate affinity chromatography and ion-e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb766b4d0b3226e2b2ddbb9ce8d2687
https://doi.org/10.1128/jvi.65.12.7004-7007.1991

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The prion protein has DNA strand transfer properties similar to retroviral nucleocapsid protein

Autor: C, Gabus, S, Auxilien, C, Péchoux, D, Dormont, W, Swietnicki, M, Morillas, W, Surewicz, P, Nandi, J L, Darlix

Publikováno v: Journal of molecular biology. 307(4)

The transmissible spongiform encephalopathies are fatal neurodegenerative diseases that are associated with the accumulation of a protease-resistant form of the cellular prion protein (PrP). Although PrP is highly conserved and widely expressed in ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c18d459921a5b841a7c7687c286eb140
https://pubmed.ncbi.nlm.nih.gov/11286552

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