Zobrazeno 1 - 10
of 30
pro vyhledávání: '"J. L. Conklin"'
Autor:
Arjan Bredenoord, John E. Pandolfino, Mark A. Fox, Jeffrey H. Peters, Annamaria Staiano, Chandra Prakash Gyawali, Sabine Roman, M. F. Vaezi, J. L. Conklin
Publikováno v:
Neurogastroenterology & Motility. 25:99-133
Esophageal motor function is highly coordinated between central and enteric nervous systems and the esophageal musculature, which consists of proximal skeletal and distal smooth muscle in three functional regions, the upper and lower esophageal sphin
Autor:
John E. Pandolfino, J. L. Conklin, Peter J. Kahrilas, Brian E. Lacy, W. Dengler, Chandra Prakash Gyawali, Joel E. Richter, Marcelo F. Vela, Ronnie Fass, Kenneth R. DeVault, Robert A. Ganz, Brant K. Oelschlager, Jeffrey H. Peters, Tom R. DeMeester
Publikováno v:
Diseases of the Esophagus. 26:755-765
Gastroesophageal reflux disease (GERD) can be difficult to diagnose - symptoms alone are often not enough, and thus, objective testing is often required. GERD is a manifestation of pathologic levels of reflux into the esophagus of acidic, nonacidic,
Autor:
J. L. Conklin, Leonardo Rodriguez, Juan C. Ayala, J. Saba, Dror Berel, P. Rodriguez, M. G. Neto, Edy E. Soffer
Publikováno v:
Neurogastroenterology & Motility. 24:446-450
Background Electrical stimulation (ES) of the lower esophageal sphincter (LES) increases resting LES pressure (LESP) in animal models. Our aims were to evaluate the safety of such stimulation in humans, and test the hypothesis that ES increases resti
Publikováno v:
Neurogastroenterology & Motility. 20:869-876
The pathogenesis of nutcracker oesophagus (NE) and ineffective oesophageal motility (IEM) is unclear. Damage to the enteric nervous system or smooth muscle can cause oesophageal dysmotility. We tested the hypothesis that NE and IEM are associated wit
Publikováno v:
Neurogastroenterology and Motility. 16:31-37
We tested the hypotheses that oesophageal bolus transit and motor function vary regionally, with bolus viscosity and with body position. In healthy volunteers, we measured the bolus head advance time, bolus presence time and bolus transit time in the
Publikováno v:
Neurogastroenterology and Motility. 15:625-633
The cyclic nucleotides adenosine 3¢,5¢-cyclic monophosphate (cAMP) and guanosine 3¢,5¢-cyclic monophosphate (cGMP) mediate the inhibitory effects of vasoactive intestinal polypeptide and nitric oxide on oesophageal smooth muscle. Phosphodiesteras
Publikováno v:
Neurogastroenterology and Motility. 15:591-606
Publikováno v:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 23(8)
Short bowel syndrome (SBS) is a serious clinical disorder characterized by diarrhea and nutritional deprivation. Glucagon-like peptide-1 (GLP-1) is a key hormone, produced by L-cells in the ileum, that regulates proximal gut transit. When extensive i
Publikováno v:
Alimentary pharmacologytherapeutics. 24(7)
Summary Background Sildenafil is an inhibitor of type 5 phosphodiesterase. It relaxes or inhibits contraction of smooth muscle by increasing cellular concentrations of cyclic guanosine monophosphate. Multichannel intraluminal impedance manometry/pH a