Zobrazeno 1 - 10
of 33
pro vyhledávání: '"J. L. Claghorn"'
Publikováno v:
Acta psychiatrica Scandinavica. 87(5)
To compare the safety and efficacy of paroxetine (n = 167) and placebo (n = 169), data from 4 centres using the same protocol were pooled. A double-blind parallel group design was used, with therapy lasting 6 weeks. Significant differences between pa
Autor:
L E Hollister, J L Claghorn
Publikováno v:
Annual review of pharmacology and toxicology. 33
Publikováno v:
The Journal of clinical psychiatry. 53(12)
Paroxetine is a potent and selective serotonin reuptake inhibitor (SSRI). The present study assessed the efficacy and tolerability of paroxetine against placebo in depressed outpatients.A double-blind, parallel-group study was undertaken in four stan
Autor:
J L, Claghorn
Publikováno v:
The Journal of clinical psychiatry.
Considerable research shows that serotonin dysfunction is implicated in major depression. Paroxetine is an investigational antidepressant that appears to act by selectively blocking neuronal serotonin uptake. Seventy-two outpatients with moderate-to-
Autor:
C K, Cohn, R, Shrivastava, J, Mendels, J B, Cohn, L F, Fabre, J L, Claghorn, E C, Dessain, T M, Itil, A, Lautin
Publikováno v:
The Journal of clinical psychiatry. 51
Two hundred forty-one elderly depressed patients entered the 8-week, double-blind phase of this parallel-group, multicenter study; 161 patients were randomized to receive sertraline (50-200 mg/day) and 80 were randomized to receive amitriptyline (50-
Publikováno v:
Acta Psychiatrica Scandinavica. 67:307-314
The effect of relaxation training, utilizing EMG biofeedback, on platelet monoamine oxidase (MAO) activity was examined in patients with a history of chronic anxiety. Anxiety scores and MAO activity were significantly lowered after 4 weeks of therapy
Autor:
J. L. Claghorn
Publikováno v:
JAMA: The Journal of the American Medical Association. 196:1089-1091
Publikováno v:
Acta psychiatrica Scandinavica. 63(3)
Levels of platelet monoamine oxidase activity, state anxiety and trait anxiety were quantified twice in 20 drug-free subjects with generalized anxiety and an equal number of healthy drug-free controls at 4-week intervals. Fiften subjects in each grou
An overview of seventeen years of experience with dothiepin in the treatment of depression in Europe
Autor:
B J, Goldstein, J L, Claghorn
Publikováno v:
The Journal of clinical psychiatry. 41(12 Pt 2)
The European clinical experience with dothiepin since 1962 indicates that it is efficacious in the treatment of depression (neurotic, psychotic, and with concomitant anxiety) in dose of 75-200 mg/day. The side effects profile is similar to the tricyc
Autor:
J L, Claghorn
Publikováno v:
The Journal of clinical psychiatry. 46(8 Pt 2)
The literature concerning the pharmacokinetics, pharmacodynamics, receptor physiology, and clinical use of molindone is reviewed. Unanswered questions about the drug are addressed. Although molindone is reputed to have a short half-life (1.5 hours),