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Bacillus anthracis Lethal Toxin Reduces Human Alveolar Epithelial Barrier Function

Autor: Jordan P. Metcalf, Tibor Z. Veres, Elizabeth S. Duggan, Armin Braun, Dennis Burian, J. L. Booth, Ryan Zander, Daniel M. Williams, Jimmy D. Ballard, Vijay Ramani, Marybeth Langer, Frauke Prenzler, Florea Lupu, Shanjana Awasthi, Robert Silasi-Mansat, Katherina Sewald, Vineet I. Patel, K. M. Coggeshall

Publikováno v: Infection and Immunity. 80:4374-4387

The lung is the site of entry for Bacillus anthracis in inhalation anthrax, the deadliest form of the disease. Bacillus anthracis produces virulence toxins required for disease. Alveolar macrophages were considered the primary target of the Bacillus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110316d3e5197725f5bd6c73da7c903c
https://doi.org/10.1128/iai.01011-12

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Alveolar escape by bacillus anthracis spores does not require a carrier cell and is not altered by lethal toxin

Autor: Armin Braun, Elizabeth S. Duggan, J. L. Booth, Marybeth Langer, K. M. Coggeshall, Vineet I. Patel, Jordan P. Metcalf

Rationale The lung is the entry site for Bacillus anthracis in inhalation anthrax, the most deadly form of the disease. B. anthracis spores must escape from the alveolus, pass to the regional lymph nodes, germinate and enter the circulatory system as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c341c8721ce3d63045e4dce559be3a
https://publica.fraunhofer.de/handle/publica/244517

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Adenovirus Type 7 Induces Interleukin-8 in a Lung Slice Model and Requires Activation of Erk

Autor: K. M. Coggeshall, J. L. Booth, Jordan P. Metcalf, B. E. Gordon

Publikováno v: Journal of Virology. 78:4156-4164

Adenovirus (Ad), particularly Ad type 7 (Ad7), causes severe lung infection and pneumonia. Initially, Ad causes neutrophilic inflammation of the distal airways and alveoli. Interleukin-8 (IL-8) is the major lung neutrophil chemotaxin, and we have sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087c1a7e2a9a81377378bff038ae8e7b
https://doi.org/10.1128/jvi.78.8.4156-4164.2004

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Adenovirus Type 7 Induces Interleukin-8 Production via Activation of Extracellular Regulated Kinase 1/2

Autor: Jordan P. Metcalf, M. J. Alcorn, J. L. Booth, K. M. Coggeshall

Publikováno v: Journal of Virology. 75:6450-6459

Infection with adenovirus serotype 7 (Ad7) frequently causes lower respiratory pneumonia and is associated with severe lung inflammation and neutrophil infiltration. Earlier studies indicated release of proinflammatory cytokines, specifically interle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c467fb8c5235b5dda4228ae6e3b2066
https://doi.org/10.1128/jvi.75.14.6450-6459.2001

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A flow cytometric protocol for titering recombinant adenoviral vectors containing the green fluorescent protein

Autor: J. L. Booth, L. R. Pennington, J. M. Gimble, Jordan P. Metcalf, V. Dandapani, D. C. Hitt

Publikováno v: Molecular Biotechnology. 14:197-203

As the use of adenoviral vectors in gene therapy protocols increases, there is a corresponding need for rapid, accurate, and reproducible titer methods. Multiple methods currently exist for determining titers of recombinant adenoviral vector, includi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c715b69c153fc73145997ee6a27cbd
https://doi.org/10.1385/mb:14:3:197

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Antiviral Innate Immune Responses in Human Bronchial Epithelial Cells (HBEC) of Smokers are Impaired through Epigenetic Modifications

Autor: Wei Zhang, J. L. Booth, Xiaoqiu Wang, Jordan P. Metcalf, Wenxin Wu

Publikováno v: Journal of Investigative Medicine. 64:960-960

Rationale Chronic obstructive pulmonary disease (COPD) is a leading global cause of morbidity and mortality. Cigarette smoking (CS) is the main risk factor for the development of COPD and most COPD exacerbations are caused by respiratory infections i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f253f71abd75129b7ed152b6bdb7814
https://doi.org/10.1136/jim-2016-000120.100

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Human alveolar epithelial barrier function is impaired by bacillus anthracis lethal toxin

Autor: J. L. Booth, Florea Lupu, Elizabeth S. Duggan, Armin Braun, Vijay Ramani, K. M. Coggeshall, Vineet I. Patel, Robert Silasi-Mansat, Jordan P. Metcalf, Shanjana Awasthi, Marybeth Langer

RATIONALE: The lung is the site of entry for Bacillus anthracis (Ba) in inhalation anthrax, the deadliest form of the disease. Ba produces virulence toxins that are necessary for clinical disease in higher animal models, including lethal toxin (LT).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad47045fc5ddb84708ff980197f3d9a
https://publica.fraunhofer.de/handle/publica/230439

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