Zobrazeno 1 - 9 of 9 pro vyhledávání: '"J. L. Bobbitt"'
1
Thrombolytic activity of a novel plasminogen activator, LY210825, compared with recombinant tissue-type plasminogen activator in a canine model of coronary artery thrombosis
Autor: Philip J. Burck, J F Quay, J L Bobbitt, Trelia J. Craft, Charles V. Jackson, V G Crowe, J L Sundboom, B W Grinnell, Gerald F. Smith
Publikováno v: Circulation. 82:930-940
LY210825, a recombinant tissue-type plasminogen activator (rt-PA), which contains the kringle-2 and serine protease functional domains of native tissue-type plasminogen activator, was previously produced by site-directed mutagenesis in a Syrian hamst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1431006b7bd026f80a6ddba01d5a6f0f
https://doi.org/10.1161/01.cir.82.3.930
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3
Recombinant human secretory phospholipase A2 released thromboxane from guinea pig bronchoalveolar lavage cells: in vitro and ex vivo evaluation of a novel secretory phospholipase A2 inhibitor
Autor: J H, Fleisch, C T, Armstrong, C R, Roman, E D, Mihelich, S M, Spaethe, W T, Jackson, J L, Bobbitt, S, Draheim, N J, Bach, R D, Dillard, M, Martinelli, R, Fouts, D W, Snyder
Publikováno v: The Journal of pharmacology and experimental therapeutics. 278(1)
The primary objective of this study was to develop a functional assay that could provide rapid and reliable information on some pharmacologic characteristics of a novel inhibitor of human secretory phospholipase A2 (sPLA2). Guinea pig bronchoalveolar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b017882cc52f03933a8bb54ca8786e7e
https://pubmed.ncbi.nlm.nih.gov/8764358
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4
Characterization of the contractile effects of human recombinant nonpancreatic secretory phospholipase A2 (PLA2) and other PLA2s on guinea pig lung pleural strips
Autor: D W, Snyder, C D, Sommers, J L, Bobbitt, E D, Mihelich
Publikováno v: The Journal of pharmacology and experimental therapeutics. 266(3)
Contractile activities of nPLA2, pPLA2 and hPLA2 were characterized on pleural strips of guinea pig lung. The rank order of potency for these PLA2s was nPLA2pPLA2hPLA2. The concentration-related contractions induced by nPLA2 (0.0002-0.67 micrograms/m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3a2efd641180e7798c91f4d6f6c3749
https://pubmed.ncbi.nlm.nih.gov/8371132
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5
Evidence that phospholipase A2 (PLA2) inhibitors can selectively block PLA2-mediated contractions of guinea pig lung pleural strips
Autor: D W, Snyder, C D, Sommers, J L, Bobbitt, E D, Mihelich
Publikováno v: The Journal of pharmacology and experimental therapeutics. 262(3)
We have demonstrated previously that porcine pancreatic phospholipase A2 (PLA2)-induced contractions of guinea pig lung pleural strips can be abated by inhibitors of cyclooxygenase and 5-lipoxygenase pathways, suggesting the liberation of arachidonic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8138ab6dcb955b506b4662ac8f6fc496
https://pubmed.ncbi.nlm.nih.gov/1527719
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6
Calcitonin stimulates plasminogen activator in porcine renal tubular cells: LLC-PK1
Autor: E Reich, J L Bobbitt, Jean-Dominique Vassalli, J M Dayer, S M Krane, R N Hull
Publikováno v: The Journal of Cell Biology
Plasminogen activators are highly selective proteases that activate the proenzyme plasminogen to the general protease, plasmin. We studied a porcine kidney cell line, originally isolated as a high producer of plasminogen activator, in which activitie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901067ccbfe0d1614b7ffd8343452666
http://europepmc.org/articles/PMC2111931
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