Výsledky vyhledávání - "J. Kyle Bruner"

Supplementary Tables S1-S2 from Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase–Driven Leukemias and Other Malignancies

Autor: Donald Small, Christine A. Pratilas, Keith W. Pratz, Mark J. Levis, Richard J. Jones, Michelle A. Rudek, Alice Can Ran Qin, Li Li, Hayley S. Ma, J. Kyle Bruner

Table S1: AML Patient Characteristics Table S2: Plasma sample characteristics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23681dc443118c6a306f8231da28ee2f
https://doi.org/10.1158/0008-5472.22414568.v1

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Supplementary Figures from Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase–Driven Leukemias and Other Malignancies

Autor: Donald Small, Christine A. Pratilas, Keith W. Pratz, Mark J. Levis, Richard J. Jones, Michelle A. Rudek, Alice Can Ran Qin, Li Li, Hayley S. Ma, J. Kyle Bruner

Figure S1: Sorafenib treatment induces phospho-ERK rebound in 32D/ITD cells. Figure S2: Further characterization of FLT3 inhibitor-mediated signaling adaptation. Figure S3: FLT3 signaling is maintained in low serum conditions. Figure S4: MEK inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fab0992900dd1d02e43c4ebf8f2c310
https://doi.org/10.1158/0008-5472.22414571

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Data from Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase–Driven Leukemias and Other Malignancies

Autor: Donald Small, Christine A. Pratilas, Keith W. Pratz, Mark J. Levis, Richard J. Jones, Michelle A. Rudek, Alice Can Ran Qin, Li Li, Hayley S. Ma, J. Kyle Bruner

FMS-like tyrosine kinase-3 (FLT3) tyrosine kinase inhibitors (TKI) have been tested extensively to limited benefit in acute myeloid leukemia (AML). We hypothesized that FLT3/internal tandem duplication (ITD) leukemia cells exhibit mechanisms of intri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::498ec01b8b7cb5fbbc354902e39bf311
https://doi.org/10.1158/0008-5472.c.6509027.v1

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All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD+ leukemia stem cells in vitro and in vivo

Autor: Courtney M. Shirley, Peter D. Aplan, Li Li, Bao Nguyen, Sarah Greenblatt, Richard J. Jones, J. Kyle Bruner, Hayley S Ma, Amy S. Duffield, Donald Small, Eric Jung, Gabriel Ghiaur

Publikováno v: Blood. 127:2867-2878

FMS-like tyrosine kinase 3 (FLT3)-mutant acute myeloid leukemia (AML) portends a poor prognosis, and ineffective targeting of the leukemic stem cell (LSC) population remains one of several obstacles in treating this disease. All-trans retinoic acid (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429732a416e11d34708a7a7c01c9e665
https://doi.org/10.1182/blood-2015-05-646786

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Identification of novel small molecule modulators of K2P18.1 two-pore potassium channel

Autor: Yixin Zhang, J. Kyle Bruner, Hongkang Zhang, Katharina Schmidt, Min Li, Beiyan Zou

Publikováno v: European Journal of Pharmacology. 740:603-610

Two-pore domain potassium (K2P) channels are responsible for background potassium (K+) current, which is crucial for the maintenance of resting membrane potential. K2P18.1, also called TWIK-related spinal cord K+ channel (TRESK) or KCNK18, is thought

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a338018c8b79feabe1961aac93335c7
https://doi.org/10.1016/j.ejphar.2014.06.021

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Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase-Driven Leukemias and Other Malignancies

Autor: Keith W. Pratz, Hayley S Ma, Michelle A. Rudek, Donald Small, Li Li, Richard J. Jones, Alice Can Ran Qin, J. Kyle Bruner, Mark J. Levis, Christine A. Pratilas

Publikováno v: Cancer research. 77(20)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7464b91ac3f88d82fbbc65e299200f
https://pubmed.ncbi.nlm.nih.gov/28923853

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Abstract 4785: Signaling adaptation to FLT3 inhibition in FLT3/ITD leukemia results in a reactivation of ERK signaling that can be abrogated with MEK inhibition

Autor: Hayley S Ma, Christine A. Pratilas, Donald Small, J. Kyle Bruner

Publikováno v: Cancer Research. 76:4785-4785

The use of FLT3 tyrosine kinase inhibitors (TKIs) for the treatment of FLT3 mutant acute myeloid leukemia (AML) has been explored as a promising strategy for over a decade. However, FLT3 TKIs have thus far shown limited clinical benefit in patients w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12c01a20a4ee83623f04732b6a12d886
https://doi.org/10.1158/1538-7445.am2016-4785

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FLT3 Inhibition and Retinoid Signaling Overcome Stromal Protection to Target FLT3/ITD-Expressing Leukemia Stem Cells in the Bone Marrow Microenvironment

Autor: Richard J. Jones, Donald Small, J. Kyle Bruner, Sarah Greenblatt, Peter D. Aplan, Megan E McCray, Bao Nguyen, Gabriel Ghiaur, Eric Jung, Li Li, Courtney M. Shirley, Amy S. Duffield, Hayley S Ma

Publikováno v: Blood. 126:790-790

While novel FLT3 tyrosine kinase inhibitors (TKIs) are increasingly efficient, when used as monotherapy they achieve only limited clinical responses in patients with FLT3/ITD acute myeloid leukemia (AML). Leukemia stem cells (LSCs) that share charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::301ad94abe677f04d0e138219e307445
https://doi.org/10.1182/blood.v126.23.790.790

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