Zobrazeno 1 - 10
of 110
pro vyhledávání: '"J. Kubar"'
Publikováno v:
The Lancet Infectious Diseases. 5:107-114
Autor:
Xavier Stien, Pierre Marty, Baharia Mograbi, D Rousseau, Bernard Ferrua, J. Kubar, Konstantina Fragaki, Isabelle Suffia
Publikováno v:
Infection and Immunity. 68:630-636
We report here the characterization of a novelLeishmania infantumprotein termed papLe22 (22-kDa potentially aggravating protein ofLeishmania). A positive clone from a cDNA library was identified by serum of a visceral leishmaniasis (VL) patient. Full
Autor:
Yves Le Fichoux, Sandrine Ruette, Dominique Grousson, J. Kubar, Bernard Ferrua, A. Lelievre, D Rousseau
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:654-658
In the immunocompetent host, visceral leishmaniasis (VL) is a fatal disease if untreated. In immunosuppressed patients, VL is an opportunistic infection for which there is no effective treatment for relapses. Here we report on the long-term activity
Publikováno v:
The Journal of Immunology. 148:672-677
We have generated stable Chinese hamster ovary (CHO) cell transfectants expressing either CD58 or CD59 or both molecules to compare their respective parts played in T cell adhesion and activation. Using a rosetting assay, we have shown the following:
Autor:
J. Kubar, Poonam Salotra, Konstantina Fragaki, Narendra Singh Negi, Gurumurthy Srividya, Ruchi Singh, Sandeep Verma, Dhiraj Kumar
Publikováno v:
Transactions of the Royal Society of Tropical Medicine and Hygiene. 102(2)
Summary The diagnostic potential of recombinant Lepp12 (rLepp12) antigen cloned from Leishmania infantum was assessed in L. donovani infections by Western blotting. Ninety-two serum samples, including 30 patients with active kala-azar (KA), 17 post-t
Autor:
Konstantina Fragaki, J. Kubar
Publikováno v:
Trends in parasitology. 22(3)
The parasite Leishmania is a major cause of disease worldwide. In the past 15 years, many groups have analysed DNA-derived proteins from Leishmania. Large amounts of data obtained by these groups can be collated to direct future research into Leishma
Publikováno v:
Journal of immunoassayimmunochemistry. 22(2)
In this report, a sandwhich ELISA was developed to quantify spleen and liver burdens from L. infantum-infected BALB/c mice. Amastigote antigens obtained following Nonidet P40 extraction of parasite-harbouring tissues were captured by anti-L. infantum
Publikováno v:
European cytokine network. 12(2)
We analyzed differential responses of spleen and liver, major organ targets for viscerotropic Leishmania species, to experimental infection and examined if resistance to challenge was organ-specific. In liver, parasites were spontaneously cleared and
Autor:
Yves Le Fichoux, Bernard Ferrua, Isabelle Suffia, Déborah Rousseau, J. Kubar, Konstantina Fragaki
Publikováno v:
Vaccine. 19(13-14)
We tested in outbred golden hamsters the protective potential of highly immunogenic Leishmania infantum protein papLe22 which we recently identified. Immunisation was performed using papLe22 cDNA, administered as a single intramuscular injection. The
Autor:
A. Lelievre, D Rousseau, Pierre Marty, J. Kubar, I Suffia, Jean-Pierre Aufeuvre, Yves Le Fichoux, Jean-François Quaranta
Publikováno v:
Journal of clinical microbiology. 37(6)
Visceral leishmaniosis (VL) due to Leishmania infantum ( L. chagasi ) is a lethal disease if untreated, but asymptomatic L. infantum infections have been reported previously. A better understanding of parasite transmission, dissemination, and surviva