Zobrazeno 1 - 10
of 179
pro vyhledávání: '"J. Koubek"'
Autor:
P. Štursa, O. Uhlík, V. Kurzawová, J. Koubek, M. Ionescu, M. Strohalm, P. Lovecká, T. Macek, M. Macková
Publikováno v:
Plant, Soil and Environment, Vol 55, Iss 9, Pp 389-396 (2009)
Until recently, investigators had no idea how accurately cultivated microorganisms represented the overall microbial diversity. The cultivation-dependent approach is limited by the fact that the overwhelming majority of microorganisms present in soil
Externí odkaz:
https://doaj.org/article/89e10463d23f4cd096e0c39384a4f84e
Autor:
Emily J. Koubek, Lorraine C. Santy
Publikováno v:
Cells, Vol 11, Iss 22, p 3565 (2022)
Dock1, originally Dock180, was the first identified member of the Dock family of GTPase Exchange Factors. Early biochemical and genetic studies of Dock180 elucidated the functions and regulation of Dock180 and informed our understanding of all Dock f
Externí odkaz:
https://doaj.org/article/d5cf28959a0e427480f320ed70d30502
Autor:
Emily J. Koubek, Jillian S. Weissenrieder, Luz E. Ortiz, Nnenna Nwogu, Alexander M. Pham, J. Dylan Weissenkampen, Jessie L. Reed, Jeffrey D. Neighbors, Raymond J. Hohl, Hyun Jin Kwun
Publikováno v:
Viruses, Vol 14, Iss 9, p 1848 (2022)
Merkel cell carcinoma (MCC) is a rare but aggressive form of skin cancer predominantly caused by the human Merkel cell polyomavirus (MCPyV). Treatment for MCC includes excision and radiotherapy of local disease, and chemotherapy or immunotherapy for
Externí odkaz:
https://doaj.org/article/14286ce877a24c61b16ace6b7873e807
Autor:
Kathleen M. Kokolus, Jeremy S. Haley, Emily J. Koubek, Raghavendra Gowda, Saketh S. Dinavahi, Arati Sharma, David F. Claxton, Klaus F. Helm, Joseph J. Drabick, Gavin P. Robertson, Jeffrey D. Neighbors, Raymond J. Hohl, Todd D. Schell
Publikováno v:
OncoImmunology, Vol 8, Iss 2 (2019)
Metastatic melanoma is a significant clinical problem with a 5-year survival rate of only 15–20%. Recent approval of new immunotherapies and targeted inhibitors have provided much needed options for these patients, in some cases promoting dramatic
Externí odkaz:
https://doaj.org/article/5046be52e262417b833f22a08b249b8a
Autor:
Emily J. Koubek, Sarah A. Buhrow, Stephanie L. Safgren, Lee Jia, Matthew P. Goetz, Matthew M. Ames, Joel M. Reid
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals.
Endoxifen (ENDX) is an active metabolite of tamoxifen (TAM) currently undergoing clinical development for estrogen receptor positive breast cancer. Here, we characterized the pharmacokinetics and oral bioavailability of ENDX in female rats and dogs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828a649052a7d41e7eef46c0bd5999f5
https://pubmed.ncbi.nlm.nih.gov/36351835
https://pubmed.ncbi.nlm.nih.gov/36351835
Publikováno v:
Journal of Chromatography B. 1221:123654
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca701f45ccc698d5b67605c341cc312a
https://doi.org/10.1016/j.jchromb.2023.123654
https://doi.org/10.1016/j.jchromb.2023.123654
Autor:
Emily J, Koubek, Rachel A, Kudgus, Chad A, Walden, Renee M, McGovern, Joseph M, Covey, Matthew M, Ames, Joel M, Reid
Publikováno v:
Cancer chemotherapy and pharmacology. 90(2)
NSC 161128, a phenylurea thiocarbamate, displays activity against the NCI60 anti-cancer cell line panel and xenograft models. The metabolite N-methyl-N'-phenylurea (M10) has been detected in animal plasma; however, detection and quantification of oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::478daa85a8cf69e866eb270986d4a6b5
https://pubmed.ncbi.nlm.nih.gov/35896839
https://pubmed.ncbi.nlm.nih.gov/35896839
Publikováno v:
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12451abd6814778049e91dd50cbc88d6
https://doi.org/10.1016/b978-0-12-820472-6.00004-9
https://doi.org/10.1016/b978-0-12-820472-6.00004-9
Autor:
Jeffrey D. Neighbors, Michelle V. Green, Jillian S. Weissenrieder, Jessie L. Reed, Emily J. Koubek, Raymond J. Hohl, George Lucian Moldovan
Publikováno v:
Pharmacology. 105:19-27
Background: Glioblastoma multiforme (GBM) is a common and lethal cancer of the central nervous system. This cancer is difficult to treat because most anticancer therapeutics do not readily penetrate into the brain due to the tight control at the cere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b1195c54970eefd841c09d173cf4c08
https://doi.org/10.1159/000502562
https://doi.org/10.1159/000502562
Publikováno v:
Lipids. 53:767-784
The schweinfurthin family of compounds displays exciting potent and differential cytotoxicity against human cancer cell lines. Currently, the effect of schweinfurthins on tumor development and progression is being explored in animal models of cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7b93d9aa71b8057b0a995d228e0cab
https://doi.org/10.1002/lipd.12088
https://doi.org/10.1002/lipd.12088