Zobrazeno 1 - 10
of 95
pro vyhledávání: '"J. Koslowski"'
Autor:
Maureen J Koslowski, Zora Teltschik, Julia Beisner, Elke Schaeffeler, Guoxing Wang, Irmgard Kübler, Michael Gersemann, Rachel Cooney, Derek Jewell, Walter Reinisch, Séverine Vermeire, Paul Rutgeerts, Matthias Schwab, Eduard F Stange, Jan Wehkamp
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002523 (2012)
Ileal Crohn's Disease (CD), a chronic small intestinal inflammatory disorder, is characterized by reduced levels of the antimicrobial peptides DEFA5 (HD-5) and DEFA6 (HD-6). Both of these α-defensins are exclusively produced in Paneth cells (PCs) at
Externí odkaz:
https://doaj.org/article/56702dae105843a4a2280f10511cdf3f
Autor:
Maureen J Koslowski, Irmgard Kübler, Mathias Chamaillard, Elke Schaeffeler, Walter Reinisch, Guoxing Wang, Julia Beisner, Alexander Teml, Laurent Peyrin-Biroulet, Stefan Winter, Klaus R Herrlinger, Paul Rutgeerts, Séverine Vermeire, Rachel Cooney, Klaus Fellermann, Derek Jewell, Charles L Bevins, Matthias Schwab, Eduard F Stange, Jan Wehkamp
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4496 (2009)
Reduced expression of Paneth cell antimicrobial alpha-defensins, human defensin (HD)-5 and -6, characterizes Crohn's disease (CD) of the ileum. TCF-4 (also named TCF7L2), a Wnt signalling pathway transcription factor, orchestrates Paneth cell differe
Externí odkaz:
https://doaj.org/article/6837cf568a854f24b2bbe8a2472f4905
Akademický článek
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Autor:
Christian Schäfer, K. Saigenji, Jan Wehkamp, Guoxing Wang, Eduard F. Stange, Maureen J. Koslowski, Miriam Schlee, Sabine Nuding, Yoshio Hosaka
Publikováno v:
European Journal of Gastroenterology & Hepatology. 20:1151-1158
BACKGROUND With the exception of fungi, microbial infections are rare in the oesophagus. Herein, we aimed to systematically assess the distribution and quantity of different antimicrobial host factors as well as, for the first time, functional mucosa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a95a3b0d88e83f5aae3b6f19b63b69
https://doi.org/10.1097/meg.0b013e3283052ddb
https://doi.org/10.1097/meg.0b013e3283052ddb
Publikováno v:
Mathematical Structures in Computer Science. 10:165-203
Linear bicategories are a generalization of bicategories in which the one horizontal composition is replaced by two (linked) horizontal compositions. These compositions provide a semantic model for the tensor and par of linear logic: in particular, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e35188010b647bdbaea972d92e69c573
https://doi.org/10.1017/s0960129520003047
https://doi.org/10.1017/s0960129520003047
Publikováno v:
Applied Categorical Structures. 2:219-244
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31132fb02647167d4f0c16dfb4887f18
https://doi.org/10.1007/bf00878099
https://doi.org/10.1007/bf00878099
Publikováno v:
Annals of the New York Academy of Sciences. 704:103-125
The rudiments of the theory of Galois connections (or residuation theory, as it is sometimes called) are provided, together with many examples and applications. Galois connections occur in profusion and are well known to most mathematicians who deal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4bef6988d3ab1b7cbe049f10d7a14db
https://doi.org/10.1111/j.1749-6632.1993.tb52513.x
https://doi.org/10.1111/j.1749-6632.1993.tb52513.x
Autor:
Maureen J. Koslowski, Lars Gustav Lyckander, Morten H. Vatn, Eduard F. Stange, Jan Wehkamp, Julia Beisner, Gøri Perminow
Publikováno v:
The American journal of gastroenterology. 105(2)
OBJECTIVES Adult ileal Crohn's disease (CD) is characterized by a specific decrease in ileal Paneth cell alpha-defensins. In addition to NOD2, we previously identified a disturbance of the Wnt-signaling transcription factor TCF-4 as a major mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5644b4c6c7625b346f0da961106cbc3e
https://pubmed.ncbi.nlm.nih.gov/19904243
https://pubmed.ncbi.nlm.nih.gov/19904243
Publikováno v:
International journal of medical microbiology : IJMM. 300(1)
Paneth cells (PCs) are specialized epithelial cells predominantly found in the small intestinal crypts of Lieberkuehn. They produce different broad spectrum antimicrobial peptides most abundantly the α-defensins HD-5 and -6 (DEFA5 und DEFA6). Both t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610e3384e58950b00a2c4b55fe8711ea
https://pubmed.ncbi.nlm.nih.gov/19850516
https://pubmed.ncbi.nlm.nih.gov/19850516