A Universal Procedure for the [F-18]Trifluoromethylation of Aryl Iodides and Aryl Boronic Acids with Highly Improved Specific Activity

Autor: Albert D. Windhorst, Dion van der Born, Romano V. A. Orru, Claudia Sewing, J. Koos D. M. Herscheid, Danielle J. Vugts

Publikováno v: van der Born, D, Sewing, C, Herscheid, J D M, Windhorst, A D, Orru, R V A & Vugts, D J 2014, ' A Universal Procedure for the [F-18]Trifluoromethylation of Aryl Iodides and Aryl Boronic Acids with Highly Improved Specific Activity ', Angewandte Chemie International Edition in English, vol. 53, no. 41, pp. 11046-11050 . https://doi.org/10.1002/anie.201406221
Angewandte Chemie International Edition in English, 53(41), 11046-11050. John Wiley and Sons Ltd

Herein, we describe a valuable method for the introduction of the [(18)F]CF3 group into arenes with highly improved specific activity by the reaction of [(18)F]trifluoromethane with aryl iodides or aryl boronic acids. This [(18)F]trifluoromethylation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961449b9c127967dd0f3d4ec91d86e1f
https://hdl.handle.net/1871.1/1776be00-f036-44e6-8119-d269c0834095

Design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinated analogues of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as potential SPECT ligands for the 5-HT1A receptor

Autor: Rana, Al Hussainy, Joost, Verbeek, Dion, van der Born, Anton H, Braker, Josée E, Leysen, Remco J, Knol, Jan, Booij, J Koos D M, Herscheid

Publikováno v: Journal of medicinal chemistry. 54(10)

Here we describe the design, synthesis, and pharmacological profile of 5-HT(1A) receptor ligands related to 1 (WAY-100635). The cyclohexyl moiety in 1 and its O-desmethylated analogue 3 were replaced by the bridgehead iodinated bridge-fused rings: ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db4a5dd222bf7a0e9f5e47fa9a4b6944
https://pubmed.ncbi.nlm.nih.gov/21520940