Zobrazeno 1 - 10
of 156
pro vyhledávání: '"J. Kobe"'
Akademický článek
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Autor:
Alan Engelman, James R. Fuchs, Pratibha C. Koneru, Ross C. Larue, Matthew J. Kobe, Augusta Jamin, Mamuka Kvaratskhelia, Ashley C. Hoyte
Publikováno v:
Journal of Biological Chemistry. 292:19814-19825
The pyridine-based multimerization selective HIV-1 integrase (IN) inhibitors (MINIs) are a distinct subclass of allosteric IN inhibitors. MINIs potently inhibit HIV-1 replication during virion maturation by inducing hyper- or aberrant IN multimerizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1051a497abff0af33a10fe9058114d86
https://doi.org/10.1074/jbc.m117.816645
https://doi.org/10.1074/jbc.m117.816645
Autor:
Tyler A. Wilson, Pratibha C. Koneru, Stephanie V. Rebensburg, Jared J. Lindenberger, Matthew J. Kobe, Nicholas T. Cockroft, Daniel Adu-Ampratwum, Ross C. Larue, Mamuka Kvaratskhelia, James R. Fuchs
Publikováno v:
ACS medicinal chemistry letters. 10(2)
[Image: see text] Allosteric HIV-1 integrase inhibitors (ALLINIs) are a new class of potential antiretroviral therapies with a unique mechanism of action and drug resistance profile. To further extend this class of inhibitors via a scaffold hopping a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d33112b13b6f91a7b538d61ada4917
https://pubmed.ncbi.nlm.nih.gov/30783506
https://pubmed.ncbi.nlm.nih.gov/30783506
Publikováno v:
Journal of Biological Chemistry. 289:8562-8569
Atherosclerosis is associated with chronic inflammation occurring over decades. The enzyme 15-lipoxygenase-2 (15-LOX-2) is highly expressed in large atherosclerotic plaques, and its activity has been linked to the progression of macrophages to the li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6802a425334000b4256e33bb3e4461f9
https://doi.org/10.1074/jbc.m113.543777
https://doi.org/10.1074/jbc.m113.543777
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
Matthew J. Kobe, Amanda E. Price, Grover L. Waldrop, Svetlana Pakhomova, Tyler S. Champion, David B. Neau, Tyler C. Broussard
Publikováno v:
Structure. 21:650-657
SummaryAcetyl-coenzyme A (acetyl-CoA) carboxylase is a biotin-dependent, multifunctional enzyme that catalyzes the regulated step in fatty acid synthesis. The Escherichia coli enzyme is composed of a homodimeric biotin carboxylase (BC), biotinylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea3d1cbf9c006865a9529e88544887d
https://doi.org/10.1016/j.str.2013.02.001
https://doi.org/10.1016/j.str.2013.02.001
Autor:
Pratibha C. Koneru, Nivedita Jena, Pratiq A. Patel, Janet Antwi, Mosaad S. Mohamed, Matthew J. Kobe, Guqin Shi, Jacques J. Kessl, Lei Feng, Chenglong Li, James R. Fuchs, Nina Kvaratskhelia, Yara E. Mansour
Employing a scaffold hopping approach, a series of allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) have been synthesized based on an indole scaffold. These compounds incorporate the key elements utilized in quinoline-based ALLINIs for binding to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295e070ab652040d73122f41f53fbf44
https://europepmc.org/articles/PMC5018460/
https://europepmc.org/articles/PMC5018460/
Autor:
M.G. Beuling, P.C.G. Agterbos, T.C.T. van Riet, J.P.T.F. Ho, R. de Vries, J. Kober, J. de Lange
Publikováno v:
Advances in Oral and Maxillofacial Surgery, Vol 9, Iss , Pp 100391- (2023)
The aim of this scoping review was to provide a clear and comprehensive overview of the available literature on forces and movements during tooth extraction. A systematic search strategy was conducted in PubMed, Embase, Web of Science (Core Collectio
Externí odkaz:
https://doaj.org/article/0f55bd9a1e0d4269933d592e91490c9f
Autor:
D. Ehrmann, V. Eichinger, I. Vesper, J. Kober, M. Kraus, V. Schäfer, N. Hermanns, B. Kulzer, S. Silbermann
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-8 (2022)
Abstract Background Diabetes self-management is a mainstay of diabetes care, but the implementation of self-management regimens into daily life is complex and often results in discouragement and distress. Modern approaches such as smartphone-based se
Externí odkaz:
https://doaj.org/article/84bfe43c495c4344b5cb28ada0857732
Autor:
Matthew J. Kobe, Marcia E. Newcomer
Publikováno v:
eLS
Lipoxygenases (LOXs) are iron-containing enzymes that catalyse the peroxidation of polyunsaturated fatty acids. In mammals, LOX products and their metabolites are potent lipid mediators that provoke diverse biological responses. These eicosanoids, de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d04cb07c0a1bff9363fb4d4ba81ce9f4
https://doi.org/10.1002/9780470015902.a0023400
https://doi.org/10.1002/9780470015902.a0023400