Zobrazeno 1 - 10
of 2 890
pro vyhledávání: '"J. Kirby"'
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Lamins A and C, encoded by the LMNA gene, are nuclear intermediate filaments that provide structural support to the nucleus and contribute to chromatin organization and transcriptional regulation. LMNA mutations cause muscular dystrophies, d
Externí odkaz:
https://doaj.org/article/e867395b14e040f1a07f09ba0225031a
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The magnetic properties of permalloy-based trilayers of the form Py0.8Cu0.2/Py0.4Cu0.6/Py/IrMn were studied as the spacer layer undergoes a paramagnetic to ferromagnetic phase transition. We find the coupling between the free Py0.8Cu0.2 laye
Externí odkaz:
https://doaj.org/article/df4837badea64e36b2a1e0f62076bba1
Autor:
David J. Kirby, Daniel B. Buchalter, Lauren Santiesteban, Mekka R. Garcia, Aaron Berger, Jacques Hacquebord, John A.I. Grossman, Andrew E. Price
Publikováno v:
Journal of Brachial Plexus and Peripheral Nerve Injury, Vol 19, Iss 01, Pp e13-e19 (2024)
Background Brachial plexus birth injury results in deficits in strength and motion, occasionally requiring surgery to restore power to the deficient external rotators of the shoulder in these patients. This is a retrospective analysis of the long-ter
Externí odkaz:
https://doaj.org/article/ac2ccf0b4cd24ecdb3ea6b22ed59a155
Publikováno v:
Bone & Joint Research, Vol 12, Iss 3, Pp 212-218 (2023)
Aims: Glucose-insulin-potassium (GIK) is protective following cardiac myocyte ischaemia-reperfusion (IR) injury, however the role of GIK in protecting skeletal muscle from IR injury has not been evaluated. Given the similar mechanisms by which cardia
Externí odkaz:
https://doaj.org/article/d03307bb551b47ac920c2097c545bfd5
Autor:
Islam R. Younis, Brian J. Kirby, Andrew N. Billin, Deqing Xiao, Qinghua Song, Timothy R. Watkins, Ahmed A. Othman
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 3, Pp 536-547 (2023)
Abstract Cilofexor is a nonsteroidal farnesoid X receptor (FXR) agonist being evaluated for treatment of nonalcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC). This work characterized the pharmacokinetics, pharmacodynamic, safe
Externí odkaz:
https://doaj.org/article/69d9d611a3b5404a88365bc742848b86
Autor:
Nathan D. Arndt, Eitan Hershkovitz, Labdhi Shah, Kristoffer Kjærnes, Chao-Yao Yang, Purnima P. Balakrishnan, Mohammed S. Shariff, Shaun Tauro, Daniel B. Gopman, Brian J. Kirby, Alexander J. Grutter, Thomas Tybell, Honggyu Kim, Ryan F. Need
Publikováno v:
Materials, Vol 17, Iss 5, p 1188 (2024)
The effect of oxygen reduction on the magnetic properties of LaFeO3−δ (LFO) thin films was studied to better understand the viability of LFO as a candidate for magnetoionic memory. Differences in the amount of oxygen lost by LFO and its magnetic b
Externí odkaz:
https://doaj.org/article/52bf8da69fd2477db92dd65f9df724bb
Autor:
Natalie M. Portwood, Magreth F. Shayo, Patrick K. Tungu, Njelembo J. Mbewe, George Mlay, Graham Small, Janneke Snetselaar, Mojca Kristan, Prisca Levy, Thomas Walker, Matthew J. Kirby, William Kisinza, Franklin W. Mosha, Mark Rowland, Louisa A. Messenger
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Novel insecticides are urgently needed to control insecticide-resistant populations of Anopheles malaria vectors. Broflanilide acts as a non-competitive antagonist of the gamma-aminobutyric acid receptor and has shown prolonged effectiveness
Externí odkaz:
https://doaj.org/article/ea4a954598584ea18fe2252deaf299e2
Autor:
Vipul Chaturvedi, Supriya Ghosh, Dominique Gautreau, William M. Postiglione, John E. Dewey, Patrick Quarterman, Purnima P. Balakrishnan, Brian J. Kirby, Hua Zhou, Huikai Cheng, Amanda Huon, Timothy Charlton, Michael R. Fitzsimmons, Caroline Korostynski, Andrew Jacobson, Lucca Figari, Javier Garcia Barriocanal, Turan Birol, K. Andre Mkhoyan, Chris Leighton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Spin-state crossovers are phenomena where, under changes in temperature or pressure, the spin-state of an ion changes. In some materials, this spin-state crossover occurs simultaneously with a metal-insulator transition, driven by a valence transitio
Externí odkaz:
https://doaj.org/article/020ab6a579264312b425513d9493191e
Autor:
Direnis Erdinc, Alejandro Rodríguez‐Luis, Mahmoud R Fassad, Sarah Mackenzie, Christopher M Watson, Sebastian Valenzuela, Xie Xie, Katja E Menger, Kate Sergeant, Kate Craig, Sila Hopton, Gavin Falkous, Genomics England Research Consortium, Joanna Poulton, Hector Garcia‐Moreno, Paola Giunti, Carlos A deMoura Aschoff, Jonas A Morales Saute, Amelia J Kirby, Camilo Toro, Lynne Wolfe, Danica Novacic, Lior Greenbaum, Aviva Eliyahu, Ortal Barel, Yair Anikster, Robert McFarland, Gráinne S Gorman, Andrew M Schaefer, Claes M Gustafsson, Robert W Taylor, Maria Falkenberg, Thomas J Nicholls
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 5, Pp n/a-n/a (2023)
Abstract Topoisomerase 3α (TOP3A) is an enzyme that removes torsional strain and interlinks between DNA molecules. TOP3A localises to both the nucleus and mitochondria, with the two isoforms playing specialised roles in DNA recombination and replica
Externí odkaz:
https://doaj.org/article/c9e7e4ced0784d4394725c67d2a116f4
Autor:
Patrick K. Tungu, Mark W. Rowland, Louisa A. Messenger, Graham J. Small, John Bradley, Janneke Snetselaar, Matthew J. Kirby, Njelembo J. Mbewe
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Indoor residual spraying (IRS) is a major method of malaria vector control across sub-Saharan Africa. Effective control is being undermined by the rapid spread of insecticide resistance. There is major investment in development of
Externí odkaz:
https://doaj.org/article/bb9956a1fd9246cc964a4c9c62aa0401