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Publikováno v:
Diabetologie und Stoffwechsel. 7:133-141
Autor:
I. Stachura, K. Peele, Carol Stolarski, V. Nebes, A. Barsouk, J. Kiljanski, John S. Kennerdell, Robert Volpé, Jack R. Wall
Publikováno v:
Thyroid. 6:353-358
Serum antibodies reactive with eye muscle autoantigens, in particular a 64-kDa protein that is also expressed in the thyroid, and the TSH receptor, are associated with the ophthalmopathy that occurs in about 50% of patients with Graves' hyperthyroidi
Publikováno v:
Orbit. 15:129-136
The authors have used the indirect immunofluorescence test to investigate reactivity of sera from patients with Graves' disease with porcine extraocular muscle and other tissue substrates. Sera from 75% of patients with thyroid-associated ophthalmopa
Autor:
D Scalise, Carol Stolarski, Mario Salvi, V. Nebes, Jack R. Wall, J. Kiljanski, M. Sato, M.B. Hayes
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 80:1226-1232
Although sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blotting are widely used to detect serum antibodies in patients with autoimmune disorders, this procedure unfolds and denatures proteins and may alter antibody-
Publikováno v:
International Archives of Allergy and Immunology. 106:204-212
The exact pathogenic mechanism of thyroid-associated ophthalmopathy (TAO) remains unclear, and extensive studies on this disorder have resulted in often conflicting data. Well-known technical difficulties including the limited access to orbital tissu
Autor:
T. Mrowiec, Janusz Nauman, Milena Slon, Edsel Ing, Carol Stolarski, J. Kiljanski, Tomasz Bednarczuk, Jack R. Wall, Andrzej Górski, John S. Kennerdell
Publikováno v:
Autoimmunity. 27(4)
Although thyroid-associated ophthalmopathy (TAO) is now generally accepted as an autoimmune inflammatory disorder of the extraocular muscles and the orbital connective tissue, its aetiopathogenesis remains poorly understood. Recent data indicate that
Autor:
K. Peele, J. S. Kennerdell, J. Pickeral, J. Kiljanski, I. Stachura, Jack R. Wall, C. Stolarski
Publikováno v:
Journal of endocrinological investigation. 20(10)
The identity and subcellular localization of the principal extraocular muscle (EOM) antigens and prevalences of the corresponding serum autoantibodies in thyroid-associated ophthalmopathy (TAO) need to be clarified. We have used porcine eye muscle ti
Autor:
V. Nebes, Carol Stolarski, A. Barsouk, Jack R. Wall, J. Kiljanski, K. Peele, Robert Volpé, John S. Kennerdell
Publikováno v:
Journal of endocrinological investigation. 19(6)
We have carried out tests for antibody-dependent cell-mediated cytotoxicity (ADCC) against extra ocular muscle (EOM), Muller’s muscle, orbital fibroblasts and skeletal muscle in patients with thyroid-associated ophthalmopathy (TAO) and related eye
Publikováno v:
Journal of endocrinological investigation. 19(5)
We have studied a possible role of T cell sensitization to eye muscle antigens in patients with thyroid-associated ophthalmology (TAO). Peripheral blood mononuclear cell (PBMC) proliferation in response to crude porcine orbital tissue antigens, parti