Zobrazeno 1 - 10
of 1 452
pro vyhledávání: '"J. Key"'
Autor:
J. Key, A.K. Mueller, S. Gispert, L. Matschke, I. Wittig, O. Corti, C. Münch, N. Decher, G. Auburger
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 114-130 (2019)
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder in the old population. Among its monogenic variants, a frequent cause is a mutation in the Parkin gene (Prkn). Deficient function of Parkin triggers ubiquitous mitochondr
Externí odkaz:
https://doaj.org/article/4275d124e4a146368edd4feee125437b
Publikováno v:
The Cryosphere, Vol 12, Pp 3373-3382 (2018)
Recent declines in Arctic sea ice and snow extent have led to an increase in the absorption of solar energy at the surface, resulting in additional surface heating and a further decline in snow and ice. Using 34 years of satellite data, 1982–201
Externí odkaz:
https://doaj.org/article/a4444130161c493084ec4035da77475f
Publikováno v:
The Cryosphere, Vol 11, Pp 2111-2116 (2017)
On the basis of a new, consistent, long-term observational satellite dataset we show that, despite the observed increase of sea ice extent in the Antarctic, absorption of solar shortwave radiation in the Southern Ocean poleward of 60° latitude is
Externí odkaz:
https://doaj.org/article/fa7538f45d6f4a9fa1effa7a6b25cd9e
Autor:
Eirini Trichia, Fiona MacLean, Aurora Perez-Cornago, Tammy Y. N. Tong, Jonathan R. Emberson, Timothy J. Key, Sarah Lewington, Jennifer L. Carter
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Fruit consumption has been associated with a lower cardiovascular disease (CVD) risk but the underlying mechanisms are unclear. We investigated the cross-sectional and prospective associations of fruit consumption with markers of
Externí odkaz:
https://doaj.org/article/f3c6675292fa48e3bb6adda89df1900f
Autor:
Yashvee Dunneram, Jia Yi Lee, Cody Z. Watling, Gary E. Fraser, Fayth Miles, Dorairaj Prabhakaran, Krithiga Shridhar, Dimple Kondal, Viswanathan Mohan, Mohammed K. Ali, Kabayam M. Venkat Narayan, Nikhil Tandon, Tammy Y. N. Tong, Tina H. T. Chiu, Ming-Nan Lin, Chin-Lon Lin, Hsin-Chou Yang, Yu-Jen Liang, Darren C. Greenwood, Huaidong Du, Zhengming Chen, Canqing Yu, Maria G. Kakkoura, Gillian K. Reeves, Keren Papier, Sarah Floud, Rashmi Sinha, Linda M. Liao, Erikka Loftfield, Janet E. Cade, Timothy J. Key, Aurora Perez-Cornago
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-19 (2024)
Abstract Background The associations of vegetarian diets with risks for site-specific cancers have not been estimated reliably due to the low number of vegetarians in previous studies. Therefore, the Cancer Risk in Vegetarians Consortium was establis
Externí odkaz:
https://doaj.org/article/dc46d9cf2ce34b83a6dc01f8223f0dc2
Autor:
Tuck Seng Cheng, Urwah Noor, Eleanor Watts, Michael Pollak, Ye Wang, James McKay, Joshua Atkins, Giovanna Masala, Maria-Jose Sánchez, Antonio Agudo, Jesús Castilla, Dagfinn Aune, Sandra M. Colorado-Yohar, Luca Manfredi, Marc J. Gunter, Valeria Pala, Andreas Josefsson, Timothy J. Key, Karl Smith-Byrne, Ruth C. Travis
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Circulating total insulin-like growth factor-I (IGF-I) is an established risk factor for prostate cancer. However, only a small proportion of circulating IGF-I is free or readily dissociable from IGF-binding proteins (its bioavail
Externí odkaz:
https://doaj.org/article/ff207dd18aa440bb8a9aaecf8c8520d6
Autor:
Keren Papier, Joshua R. Atkins, Tammy Y. N. Tong, Kezia Gaitskell, Trishna Desai, Chibuzor F. Ogamba, Mahboubeh Parsaeian, Gillian K. Reeves, Ian G. Mills, Tim J. Key, Karl Smith-Byrne, Ruth C. Travis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The availability of protein measurements and whole exome sequence data in the UK Biobank enables investigation of potential observational and genetic protein-cancer risk associations. We investigated associations of 1463 plasma proteins with
Externí odkaz:
https://doaj.org/article/55127cf5124246838e811d932f16b540
Autor:
Trishna A. Desai, Åsa K. Hedman, Marios Dimitriou, Mine Koprulu, Sandy Figiel, Wencheng Yin, Mattias Johansson, Eleanor L. Watts, Joshua R. Atkins, Aleksandr V. Sokolov, Helgi B. Schiöth, Marc J. Gunter, Konstantinos K. Tsilidis, Richard M. Martin, Maik Pietzner, Claudia Langenberg, Ian G. Mills, Alastair D. Lamb, Anders Mälarstig, Tim J. Key, Ruth C. Travis, Karl Smith-Byrne
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105168- (2024)
Summary: Background: Understanding the role of circulating proteins in prostate cancer risk can reveal key biological pathways and identify novel targets for cancer prevention. Methods: We investigated the association of 2002 genetically predicted ci
Externí odkaz:
https://doaj.org/article/1ace1755f8ce4d638c80b4c3f3d25968
Autor:
Aurora Perez‐Cornago, Karl Smith‐Byrne, Emma Hazelwood, Cody Z. Watling, Susan Martin, Timothy Frayling, Sarah Lewis, Richard M. Martin, Hanieh Yaghootkar, Ruth C. Travis, Timothy J. Key
Publikováno v:
Cancer Medicine, Vol 12, Iss 15, Pp 16482-16489 (2023)
Abstract Background The associations of adiposity with aggressive prostate cancer risk are unclear. Using two‐sample Mendelian randomization, we assessed the association of metabolically unfavourable adiposity (UFA), favourable adiposity (FA) and f
Externí odkaz:
https://doaj.org/article/6d8e975a792541ce88213c1f7c3d6cf4
Autor:
Julie A. Schmidt, Inge Huybrechts, Kim Overvad, Anne Kirstine Eriksen, Anne Tjønneland, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Valeria Pala, Carlotta Sacerdote, Rosario Tumino, Bas Bueno‐de‐Mesquita, Maria‐Jose Sánchez, José M. Huerta, Aurelio Barricarte, Pilar Amiano, Antonio Agudo, Anders Bjartell, Tanja Stocks, Elin Thysell, Maria Wennberg, Elisabete Weiderpass, Ruth C. Travis, Timothy J. Key, Aurora Perez‐Cornago
Publikováno v:
Cancer Medicine, Vol 12, Iss 4, Pp 4725-4738 (2023)
Abstract Background The association between protein intake and prostate cancer risk remains unclear. Aims To prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with
Externí odkaz:
https://doaj.org/article/f4f62de89c6743d6817a6aef978393a4