Zobrazeno 1 - 10
of 65
pro vyhledávání: '"J. Keusch"'
Autor:
Pooja Kumari, Florian Aeschimann, Dimos Gaidatzis, Jeremy J. Keusch, Pritha Ghosh, Anca Neagu, Katarzyna Pachulska-Wieczorek, Janusz M. Bujnicki, Heinz Gut, Helge Großhans, Rafal Ciosk
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The C. elegans LIN-41 and its homologs, including human TRIM71/LIN41, contain the RNA binding NHL domain. Here the authors combine computational analysis, structural biology and in vivo studies, to explain how these proteins bind RNA and how rapid ev
Externí odkaz:
https://doaj.org/article/5a8959f36aff458cb62b172ede6df265
Autor:
Ulrike Kutay, Yasuyuki Miyake, Laure Decamps, Yohei Yamauchi, Sho Iketani, Ari Helenius, Heinz Gut, Hung Ho-Xuan, Jeremy J. Keusch
Publikováno v:
Miyake, Y, Keusch, J J, Decamps, L, Ho-Xuan, H, Iketani, S, Gut, H, Kutay, U, Helenius, A & Yamauchi, Y 2019, ' Influenza virus uses transportin 1 for vRNP debundling during cell entry ', Nature Microbiology, vol. 4, no. 4, pp. 578-586 . https://doi.org/10.1038/s41564-018-0332-2
Influenza A virus is a pathogen of great medical impact. To develop novel antiviral strategies, it is essential to understand the molecular aspects of virus–host cell interactions in detail. During entry, the viral ribonucleoproteins (vRNPs) that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099d93fb5bb5086399d65a23d89fd015
https://doi.org/10.1038/s41564-018-0332-2
https://doi.org/10.1038/s41564-018-0332-2
Autor:
Cristina Tocchini, Jeremy J Keusch, Sarah B Miller, Susanne Finger, Heinz Gut, Michael B Stadler, Rafal Ciosk
Publikováno v:
PLoS Genetics, Vol 10, Iss 8, p e1004533 (2014)
The mechanisms controlling cell fate determination and reprogramming are fundamental for development. A profound reprogramming, allowing the production of pluripotent cells in early embryos, takes place during the oocyte-to-embryo transition. To unde
Externí odkaz:
https://doaj.org/article/98c8ffd77d664743a968903775a146ad
Autor:
Dimos Gaidatzis, Pooja Kumari, Anca Neagu, Pritha Ghosh, Janusz M. Bujnicki, Rafal Ciosk, Heinz Gut, Katarzyna Pachulska-Wieczorek, Helge Großhans, Jeremy J. Keusch, Florian Aeschimann
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Nature Communications
RNA-binding proteins regulate all aspects of RNA metabolism. Their association with RNA is mediated by RNA-binding domains, of which many remain uncharacterized. A recently reported example is the NHL domain, found in prominent regulators of cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd577be1f99c457faf98f7e78c486366
https://doaj.org/article/5a8959f36aff458cb62b172ede6df265
https://doaj.org/article/5a8959f36aff458cb62b172ede6df265
Autor:
Heinz Gut, Jeremy J. Keusch, Kiran Challa, Ishan Deshpande, Susan M. Gasser, Vytautas Iesmantavicius
Publikováno v:
EMBO J
In Saccharomyces cerevisiae, the silent information regulator (SIR) proteins Sir2/3/4 form a complex that suppresses transcription in subtelomeric regions and at the homothallic mating-type (HM) loci. Here, we identify a non-canonical BRCA1 C-termina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf21c0b74c63fc6932fc6774d5189ad8
https://europepmc.org/articles/PMC6792019/
https://europepmc.org/articles/PMC6792019/
Autor:
Patrick Matthias, Daniel Hess, Makoto Saito, Longlong Wang, Heinz Gut, Paul Helquist, Yasuyuki Miyake, Xiaoning Wang, Jeremy J. Keusch, Bruce J. Melancon
Publikováno v:
Nature Chemical Biology. 12:748-754
We report crystal structures of zebrafish histone deacetylase 6 (HDAC6) catalytic domains in tandem or as single domains in complex with the (R) and (S) enantiomers of trichostatin A (TSA) or with the HDAC6-specific inhibitor nexturastat A. The tande
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c21daff64cd5d4f0396a8a35bafb79e
https://doi.org/10.1038/nchembio.2140
https://doi.org/10.1038/nchembio.2140
Autor:
Yasuyuki, Miyake, Jeremy J, Keusch, Laure, Decamps, Hung, Ho-Xuan, Sho, Iketani, Heinz, Gut, Ulrike, Kutay, Ari, Helenius, Yohei, Yamauchi
Publikováno v:
Nature microbiology. 4(4)
Influenza A virus is a pathogen of great medical impact. To develop novel antiviral strategies, it is essential to understand the molecular aspects of virus-host cell interactions in detail. During entry, the viral ribonucleoproteins (vRNPs) that car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d02d915ba777b71e7d9e50279d907243
https://pubmed.ncbi.nlm.nih.gov/30692667
https://pubmed.ncbi.nlm.nih.gov/30692667
Autor:
N. W. Muriithi, John T. Brooks, A. Jatta, R. Mayer, Tian Tang, B. John, K. Sweet, C. A. Barber, E. Rowlinson, L. VanderBusch, J. R. Coyle, J. R. Reuer, Karin A Bosh, S. Speers, Chitra Ramaswamy, L. E. Yerkes, Lindsay Legault Bouton, E. M. Kim, W. Li, A. Nishimura, V. Hansen, L. Hoffman-Arriaga, H. I. Hall, Lorene M. Maddox, A. O. Carter, Lauren J. Stockman, R. Bhattacharjee, C. Flynn, Eyasu H. Teshale, Emily Westheimer, S. Khuwaja, M. Comer, J. Keusch, A. Vu, W. Zhou, A. D. Brantley
Publikováno v:
Epidemiology and infection. 146(7)
Coinfection with human immunodeficiency virus (HIV) and viral hepatitis is associated with high morbidity and mortality in the absence of clinical management, making identification of these cases crucial. We examined characteristics of HIV and viral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f32b7989f87fee8fd7a0ac0921942e6
https://pubmed.ncbi.nlm.nih.gov/29636119
https://pubmed.ncbi.nlm.nih.gov/29636119
Autor:
Peng Liu, Zhe Yang, Bradley J. Keusch, Ladislau C. Kovari, Shaoman Zhou, Benjamin D. Kuiper, Joshua Holcomb, Iulia A. Kovari, Franck Amblard, Raymond F. Schinazi, Kendall M. Muzzarelli
Publikováno v:
Infect Disord Drug Targets
BACKGROUND: Noroviruses are the leading cause of acute gastroenteritis worldwide. Norovirus proteases, which are responsible for cleavage of the viral polyprotein, have become an attractive drug target to treat norovirus infections. Genogroup II (GII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d00919e7912490eb04c99fb66b42e9
https://pubmed.ncbi.nlm.nih.gov/29779487
https://pubmed.ncbi.nlm.nih.gov/29779487
Autor:
Mariano Oppikofer, Susan M. Gasser, Markus Hassler, Andreas G. Ladurner, Jeremy J. Keusch, Heinz Gut, Stephanie Kueng
Publikováno v:
The EMBO journal
Gene silencing in budding yeast relies on the binding of the Silent Information Regulator (Sir) complex to chromatin, which is mediated by extensive interactions between the Sir proteins and nucleosomes. Sir3, a divergent member of the AAA+ ATPase-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4ac7c2affb27f8e94aa24b9b6e7bd4