Zobrazeno 1 - 10 of 453 pro vyhledávání: '"J. Keski-Oja"'
1
Apoptosis of human endothelial cells is accompanied by proteolytic processing of latent TGF-β binding proteins and activation of TGF-β
Autor: J Keski-Oja, V T Solovyan
Publikováno v: Cell Death & Differentiation. 12:815-826
Transforming growth factors beta (TGF-betas) are multifunctional cytokines that modulate cell growth, differentiation and apoptosis. Numerous effects initiated by TGF-betas in vitro have been described, but the role of TGF-beta targeting and activati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fd344cfbe782725980821c0db41a67
https://doi.org/10.1038/sj.cdd.4401618
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2
Cellular Senescence
Autor: K, Koli, J, Keski-Oja
Publikováno v: Annals of Medicine. 24:313-318
The ageing of cells, cellular senescence, is an event that is encountered in all normal cells. Cells grown in vitro have a limited life span and do not grow well after a certain number of divisions. They cease to divide and eventually die. In accorda
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988324711a20a0b1d31eab7622ab1f5c
https://doi.org/10.3109/07853899209147829
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4
Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells
Autor: Ari Tuuttila, J. Lohi, J. Keski-Oja, Louise T. Chow, Pirkko Huhtala, Karl Tryggvason
Publikováno v: Journal of Biological Chemistry. 266:16485-16490
The complete structure of the human gene for 92-kDa type IV collagenase was determined. Two overlapping genomic clones spanning 26 kilobases (kb) of genomic DNA were shown to contain the entire 7.7-kb structural gene together with 15 and 3.5 kb of 5'
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c836296c120e461aa6fa5758797ae74
https://doi.org/10.1016/s0021-9258(18)55326-6
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5
TGF-beta 1 modulation of urokinase and PAI-1 expression in human bronchial epithelial cells
Autor: M. B. Seddon, B. I. Gerwin, J. Keski-Oja, C. C. Harris, J. F. Lechner
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 259:L262-L269
Normal human bronchial epithelial (NHBE) cells respond to signals initiated by the binding of transforming growth factor-beta type 1 (TGF-beta 1) to its surface receptors by activating pathways that result in terminal squamous differentiation. By use
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbd25d211ff722ef6a25159d076085c
https://doi.org/10.1152/ajplung.1990.259.4.l262
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6
Gremlin localization and expression levels partially differentiate idiopathic interstitial pneumonia severity and subtype
Autor: M, Myllärniemi, K, Vuorinen, V, Pulkkinen, H, Kankaanranta, T, Aine, K, Salmenkivi, J, Keski-Oja, K, Koli, Vl, Kinnula
Publikováno v: The Journal of pathology. 214(4)
Idiopathic pulmonary fibrosis (IPF) (histopathology of usual interstitial pneumonia, UIP) and non-specific interstitial pneumonia (NSIP) are diseases characterized by loss of normal lung architecture and function. The differential diagnosis between I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::17d91fd9734333caa31fdfec0debb6c5
https://pubmed.ncbi.nlm.nih.gov/18072275
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7
Latency, activation, and binding proteins of TGF-beta
Autor: K, Koli, J, Saharinen, M, Hyytiäinen, C, Penttinen, J, Keski-Oja
Publikováno v: Microscopy research and technique. 52(4)
The TGF-beta superfamily of growth factors consists of an increasing number of different polypeptide modulators of cell growth, differentiation, and morphogenesis. Three mammalian isoforms have been molecularly cloned. Numerous ways to regulate the e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::34c1d2d15f89896770a51848e5a812eb
https://pubmed.ncbi.nlm.nih.gov/11170294
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8
1alpha,25-dihydroxyvitamin D3 and its analogues down-regulate cell invasion-associated proteases in cultured malignant cells
Autor: K, Koli, J, Keski-Oja
Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 11(4)
Vitamin D and its derivatives (deltanoids) are potent regulators of cell proliferation and differentiation. Targeted production of proteolytic enzymes like serine proteases and metalloproteinases is an important part of the invasive process of cancer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff77d9b1f3a74b8337ddb3e987e808e4
https://pubmed.ncbi.nlm.nih.gov/10775039
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10
Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion
Autor: J, Taipale, J, Saharinen, J, Keski-Oja
Publikováno v: Advances in cancer research. 75
Growth factors of the transforming growth factor-beta (TGF-beta) family inhibit the proliferation of epithelial, endothelial, and hematopoietic cells, and stimulate the synthesis of extracellular matrix components. TGF-beta s are secreted from cells
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2b9a04fa0f5a9205da37f2f4536dbfb
https://pubmed.ncbi.nlm.nih.gov/9709808
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