Zobrazeno 1 - 10
of 136
pro vyhledávání: '"J. Keirns"'
Publikováno v:
Drug Metabolism Letters. 5:114-125
Vernakalant hydrochloride is a novel antiarrhythmic drug for the rapid conversion of atrial fibrillation to sinus rhythm and prevention of relapse. In this open-label, parallel design study, 8 healthy men received single 240-mg doses of [ 14 C]vernak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8148916c6f4dc1934368a54ffb9cc5c0
https://doi.org/10.2174/187231211795305249
https://doi.org/10.2174/187231211795305249
Publikováno v:
Journal of cardiovascular electrophysiology. 25(11)
The Holter bin method evaluates QT interval changes in the presence of heart rate changes without correcting the QT interval. However, the method does not allow time-matched comparisons, thus contradicting available guidance and good practice. We rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::694ad36ffd1d4ee31c3b861acf3c1342
https://pubmed.ncbi.nlm.nih.gov/24801246
https://pubmed.ncbi.nlm.nih.gov/24801246
Autor:
R A, Smulders, W, Zhang, S A, Veltkamp, J, van Dijk, W J J, Krauwinkel, J, Keirns, T, Kadokura
Publikováno v:
Diabetes, obesitymetabolism. 14(10)
To investigate the effect of ipragliflozin on the pharmacokinetics of sitagliptin, pioglitazone or glimepiride and vice versa in healthy subjects.Three trials with an open-label, randomized, two-way crossover design were conducted in healthy subjects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c52219bc91d6f6b9ebcc0e76f5be373a
https://pubmed.ncbi.nlm.nih.gov/22587345
https://pubmed.ncbi.nlm.nih.gov/22587345
Publikováno v:
Drug metabolism letters. 5(2)
Vernakalant hydrochloride is a novel antiarrhythmic drug for the rapid conversion of atrial fibrillation to sinus rhythm and prevention of relapse. In this open-label, parallel design study, 8 healthy men received single 240-mg doses of [(14)C]vernak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13d39fd2ea908ec5c69edea7119915fe
https://pubmed.ncbi.nlm.nih.gov/21457140
https://pubmed.ncbi.nlm.nih.gov/21457140
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(12)
The study objectives were to characterize the metabolism of nevirapine (NVP) in mouse, rat, rabbit, dog, monkey, and chimpanzee after oral administration of carbon-14-labeled or -unlabeled NVP. Liquid scintillation counting quantitated radioactivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::732051f2557adf01a8a54f7d079a4f37
https://pubmed.ncbi.nlm.nih.gov/10570025
https://pubmed.ncbi.nlm.nih.gov/10570025
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(12)
Nevirapine (NVP), a non-nucleoside inhibitor of HIV-1 reverse transcriptase, is concomitantly administered to patients with a variety of medications. To assess the potential for its involvement in drug interactions, cytochrome P-450 (CYP) reaction ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6629b920a0f8f1d2fca047eb271e1341
https://pubmed.ncbi.nlm.nih.gov/10570031
https://pubmed.ncbi.nlm.nih.gov/10570031
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(8)
The pharmacokinetics and biotransformation of the antiretroviral agent nevirapine (NVP) after autoinduction were characterized in eight healthy male volunteers. Subjects received 200-mg NVP tablets once daily for 2 weeks, followed by 200 mg twice dai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b1616c6229dabb1c568115fdb8873b3
https://pubmed.ncbi.nlm.nih.gov/10421616
https://pubmed.ncbi.nlm.nih.gov/10421616
Autor:
David J. Hauss, James J. Keirns, Andrew A. Jayaraj, James V. Ficorilli, Caswall A. Price, Tapon Roy, Steven E. Fogal
Publikováno v:
Journal of pharmaceutical sciences. 87(2)
Ontazolast is a potent inhibitor (IC50 = 1 nm) of calcium ionophore A23187-stimulated leukotriene B4 (LTB4) biosynthesis in human peripheral blood leukocytes. The compound is practically insoluble in water (0.14 microgram/mL) and previous studies in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ae68dfc690e457eedeebd4428dbb33
https://pubmed.ncbi.nlm.nih.gov/9519148
https://pubmed.ncbi.nlm.nih.gov/9519148
Publikováno v:
Theriogenology. 46(4)
The objective of this study was to assess the effect of various aspects of pronuclear DNA microinjection on the early development of porcine ova in utero. Estrus was synchronized and superovulation was achieved in sexually mature gilts by the adminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c424d5cb6d92e8688a962c308b2fdc76
https://pubmed.ncbi.nlm.nih.gov/16727935
https://pubmed.ncbi.nlm.nih.gov/16727935
Publikováno v:
Theriogenology. 39(3)
The objective of this study was to compare recovery of pronuclear and 2-cell ova from F2 50% Meishan (MX) gilts versus F1 White line (L42) gilts. Sexually mature MX and L42 gilts were allocated across 2 treatments: Super (MX:n=9; L42:n=10) and Contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf1dd8e1bba80993d2a1a1488b4a9df
https://pubmed.ncbi.nlm.nih.gov/16727251
https://pubmed.ncbi.nlm.nih.gov/16727251