Zobrazeno 1 - 10
of 2 340
pro vyhledávání: '"J. Kaye"'
Autor:
W. R. Wieder, D. Pierson, S. Earl, K. Lajtha, S. G. Baer, F. Ballantyne, A. A. Berhe, S. A. Billings, L. M. Brigham, S. S. Chacon, J. Fraterrigo, S. D. Frey, K. Georgiou, M.-A. de Graaff, A. S. Grandy, M. D. Hartman, S. E. Hobbie, C. Johnson, J. Kaye, E. Kyker-Snowman, M. E. Litvak, M. C. Mack, A. Malhotra, J. A. M. Moore, K. Nadelhoffer, C. Rasmussen, W. L. Silver, B. N. Sulman, X. Walker, S. Weintraub
Publikováno v:
Earth System Science Data, Vol 13, Pp 1843-1854 (2021)
Data collected from research networks present opportunities to test theories and develop models about factors responsible for the long-term persistence and vulnerability of soil organic matter (SOM). Synthesizing datasets collected by different resea
Externí odkaz:
https://doaj.org/article/0edb026e89274c85a34e73ff39866af2
Autor:
M. K. Javaid, L. Forestier-Zhang, L. Watts, A. Turner, C. Ponte, H. Teare, D. Gray, N. Gray, R. Popert, J. Hogg, J. Barrett, R. Pinedo-Villanueva, C. Cooper, R. Eastell, N. Bishop, R. Luqmani, P. Wordsworth, J. Kaye
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 11, Iss 1, Pp 1-9 (2016)
Abstract Background Research into rare diseases is becoming more common, with recognition of the significant diagnostic and therapeutic care gaps. Registries are considered a key research methodology to address rare diseases. This report describes th
Externí odkaz:
https://doaj.org/article/4af84300eeb5452c97a60ec40387d3a2
Autor:
S. L. Brantley, R. A. DiBiase, T. A. Russo, Y. Shi, H. Lin, K. J. Davis, M. Kaye, L. Hill, J. Kaye, D. M. Eissenstat, B. Hoagland, A. L. Dere, A. L. Neal, K. M. Brubaker, D. K. Arthur
Publikováno v:
Earth Surface Dynamics, Vol 4, Iss 1, Pp 211-235 (2016)
Many scientists have begun to refer to the earth surface environment from the upper canopy to the depths of bedrock as the critical zone (CZ). Identification of the CZ as an integral object worthy of study implicitly posits that the study of the whol
Externí odkaz:
https://doaj.org/article/0ad7a81d06044e66bbe2d235917e73a5
Autor:
Padmanee Sharma, Asim Amin, Dung T Le, Michael A Morse, Marina Tschaika, Matthew H Taylor, Margaret Callahan, Katriina J Peltola, Frederic J Kaye, Eileen M O'Reilly, Stephanie Meadows Shropshire, Shaun O'Brien
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 2 (2024)
Background Pancreatic cancer is one of the deadliest cancer types and represents a major unmet medical need. CheckMate 032 investigated safety and efficacy of nivolumab monotherapy and nivolumab plus ipilimumab with/without cobimetinib in advanced/me
Externí odkaz:
https://doaj.org/article/45a8cb7600f34aa197804f7caa0fc19c
Autor:
Sajid Khan, Lin Cao, Janet Wiegand, Peiyi Zhang, Maria Zajac-Kaye, Frederic J. Kaye, Guangrong Zheng, Daohong Zhou
Publikováno v:
Cells, Vol 13, Iss 6, p 528 (2024)
BCL-xL and BCL-2 are validated therapeutic targets in small-cell lung cancer (SCLC). Targeting these proteins with navitoclax (formerly ABT263, a dual BCL-xL/2 inhibitor) induces dose-limiting thrombocytopenia through on-target BCL-xL inhibition in p
Externí odkaz:
https://doaj.org/article/a29e79df61604c65a48287af106a045c
Autor:
Sajid Khan, Patrick Kellish, Nick Connis, Dinesh Thummuri, Janet Wiegand, Peiyi Zhang, Xuan Zhang, Vivekananda Budamagunta, Nan Hua, Yang Yang, Umasankar De, Lingtao Jin, Weizhou Zhang, Guangrong Zheng, Robert Hromas, Christine Hann, Maria Zajac-Kaye, Frederic J. Kaye, Daohong Zhou
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Small-cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. The dismal prognosis in SCLC is in part associated with an upregulation of BCL-2 family anti-apoptotic proteins, including BCL-XL and MCL-1. Unfortun
Externí odkaz:
https://doaj.org/article/35172677c9ab498385ddea2d7bbcff21
Autor:
Maria V. Guijarro, Patrick C. Kellish, Peter E. Dib, Nicholas G. Paciaroni, Akbar Nawab, Jacob Andring, Lidia Kulemina, Nicholas V. Borrero, Carlos Modenutti, Michael Feely, Elham Nasri, Robert P. Seifert, Xiaoping Luo, Richard L. Bennett, Daniil Shabashvili, Jonathan D. Licht, Robert McKenna, Adrian Roitberg, Robert W. Huigens III, Frederic J. Kaye, Maria Zajac-Kaye
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
Although thymidylate synthase (TYMS) inhibitors have served as components of chemotherapy regimens, the currently available inhibitors induce TYMS overexpression or alter folate transport/metabolism feedback pathways that tumor cells exploit for drug
Externí odkaz:
https://doaj.org/article/880157298af5466e978ad20aa4f783da
Autor:
Jaclyn M. Hall, Rahma S. Mkuu, Hee Deok Cho, Jennifer N. Woodard, Frederic J. Kaye, Jiang Bian, Elizabeth A. Shenkman, Yi Guo
Publikováno v:
Cancers, Vol 15, Iss 21, p 5226 (2023)
Despite advances in cancer screening, late-stage cancer diagnosis is still a major cause of morbidity and mortality in the United States. In this study, we aim to understand demographic and geographic factors associated with receiving a late-stage di
Externí odkaz:
https://doaj.org/article/346f74238e764b47a2f8727d008254d6
Autor:
Vinod Vijayakurup, Kyungah Maeng, Hye Seung Lee, Benjamin Meyer, Sandra Burkett, Akbar Nawab, Michael W. Dougherty, Christian Jobin, Iqbal Mahmud, Timothy J. Garrett, Michael Feely, Kyoung Bun Lee, Frederic J. Kaye, Maria V. Guijarro, Maria Zajac-Kaye
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Clinical studies of cancer patients have shown that overexpression or amplification of thymidylate synthase (TS) correlates with a worse clinical outcome. We previously showed that elevated TS exhibits properties of an oncogene and promotes pancreati
Externí odkaz:
https://doaj.org/article/c4d8ea92daf8429f8458305e8f8361ea
Publikováno v:
European Medical Journal Gastroenterology (2022)
Boerhaave syndrome (BS) is a full thickness oesophageal tear. Most cases require surgical correction. In rare cases, conservative management can be attempted. This case describes a 30-year-old patient with a history of BS 9 months prior, managed cons
Externí odkaz:
https://doaj.org/article/419db14222ba4b5ba9f7b9df3d3a6621