Zobrazeno 1 - 10
of 120
pro vyhledávání: '"J. Kallman"'
Autor:
Han Xia, Stephen R. Groskreutz, Michael O. Frederick, Michael E. Kopach, Nessa Mullane, Jeffrey T. Lampert, Kevin D. Seibert, Mark A. Strege, Neil J. Kallman, Bradley M. Campbell, Sergey V. Tsukanov, Frank L. Torres Torres, Ashley A. Humenik, Gordon R. Lambertus, Nil Tandogan, Nicholas D. Klitzing, Carmel Condon, Shujauddin M. Changi, Joel R. Calvin, Jennifer McClary Groh, Timothy M. Braden, Marie E. O’Mahony, Juliana Kretsinger, Rachel N. Richey, Stephanie R. Coffin, Laura M. Maguire, Richard D. Spencer, Raymond A. Boyse, Zachary D. Harms, John D. Murphy, Humphrey A. Moynihan, Olivia Gowran
Publikováno v:
Organic Process Research & Development. 25:1628-1636
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2449a6ebf10ca890f8df99ddd862ff5
https://doi.org/10.1021/acs.oprd.1c00108
https://doi.org/10.1021/acs.oprd.1c00108
Diastereoselective Pictet-Spengler Based Synthesis of a Chiral Tetrahydroisoquinoline D1 Potentiator
Publikováno v:
The Journal of organic chemistry. 85(11)
A practical synthesis of a D1 potentiator chiral tetrahydroisoquinoline has been accomplished employing diastereoselective Pictet-Spengler methodology to access the required trans-stereochemistry. A dynamic kinetic resolution by crystallization gives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a92e691b37c81def6dd137fb254b89
https://pubmed.ncbi.nlm.nih.gov/32402198
https://pubmed.ncbi.nlm.nih.gov/32402198
Autor:
Neil J. Kallman, Bradley M. Campbell, David Mitchell, Declan Hurley, Jim Cashman, Thomas M. Koenig, Michael R. Heller, Richard D. Miller, Christopher S. Polster, Olivia Gowran, Scott A. May, Kenneth Desmond, Paul E. Sheehan, Robert Moylan, Paul Desmond, Martin D. Johnson, David P. Myers, Jennifer McClary Groh, Joseph L. Phillips, William D. Diseroad, John R. Howell, Timothy D. White, Christopher L. Burcham, Myers Steven Scott, Kevin P. Cole, Richard D. Spencer
Publikováno v:
Science. 356:1144-1150
Advances in drug potency and tailored therapeutics are promoting pharmaceutical manufacturing to transition from a traditional batch paradigm to more flexible continuous processing. Here we report the development of a multistep continuous-flow CGMP (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286c7186d5b23cf038f82ff1012530e4
https://doi.org/10.1126/science.aan0745
https://doi.org/10.1126/science.aan0745
Autor:
Tony Y. Zhang, Hannah Yu, John R. Rizzo, Jeffrey A. Ward, Thomas M. Koenig, Rachel N. Richey, David Mitchell, Marvin M. Hansen, Neil J. Kallman, Ryan J. Linder
Publikováno v:
Organic Process Research & Development. 21:208-217
A practical pilot plant convergent synthesis of MR antagonist LY2623091 was established. For synthesis convergence, a vinyl bromide geometric isomer and chiral alaninol derivative were required building blocks. Key to the synthesis route development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2ee0fb900112e1b3496fccfb18c02c0
https://doi.org/10.1021/acs.oprd.6b00368
https://doi.org/10.1021/acs.oprd.6b00368
Autor:
Jonas Y. Buser, David Mitchell, Thomas M. Koenig, LuAnne M. McNulty, Neil J. Kallman, Adam D. McFarland, Kevin P. Cole
Publikováno v:
Synthesis. 48:3537-3543
A single-step method and a two-step method for the synthesis of aminopyrazoles from isoxazoles are presented and compared. Based on in situ NMR monitoring, both processes proceed through a ketonitrile. In the single-step process, hydrazine serves to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2841301ae70a2dde62f55e7c010f598
https://doi.org/10.1055/s-0035-1561861
https://doi.org/10.1055/s-0035-1561861
Autor:
Eugene F. Kogut, Neil J. Kallman, Dana L. T. Laird, Marvin M. Hansen, J. Craig Ruble, Chin Liu, Lawrence Edward Patterson, Matthew H. Yates, Ryan J. Linder
Publikováno v:
Organic Process Research & Development. 18:501-510
The synthesis of a MET kinase inhibitor in an overall yield of 22% was achieved over eight steps starting with 3-hydroxybenzaldehyde, an improvement from the initial 12-step process with a 5.4% yield. Highlights of the process chemistry design and de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4ae30531806f0a8ac97541e471ca6e4
https://doi.org/10.1021/op400317z
https://doi.org/10.1021/op400317z
Autor:
Thomas M. Koenig, Hossam Moursy, Norma Scully, Utpal K. Singh, Neil J. Kallman, Jonas Y. Buser, Jeremy M. Merritt, Alison N. Campbell, Jared W. Fennell, Mark A. Pietz
Publikováno v:
Organic Process Research & Development. 18:246-256
A mechanistic approach was undertaken to understand the oxygen sensitivity of a Pd-catalyzed amination reaction used in the synthesis of an active pharmaceutical ingredient. FlowNMR and dissolved oxygen probes were used as process analytical technolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95c46e60c18c6c78c1570fbe12aff961
https://doi.org/10.1021/op400226m
https://doi.org/10.1021/op400226m
Autor:
S.P. Gerhardt, Vlad Soukhanovskii, J. Kallman, A. L. Roquemore, Jean Paul Allain, Adam McLean, Chase N. Taylor, Tyler Abrams, M. Ono, S.F. Paul, B.P. LeBlanc, Roger Raman, B. Heim, Michael Jaworski, C.H. Skinner, R.E. Bell, Robert Kaita, Leonid E. Zakharov, D. Mueller, Mario Podesta, S.A. Sabbagh, S.M. Kaye, Richard E. Nygren, D.K. Mansfield, H.W. Kugel, Ahmed Diallo, Jonathan Menard, Rajesh Maingi, Filippo Scotti, M.G. Bell
Publikováno v:
Journal of Nuclear Materials. 438:S488-S492
Deuterium fueling experiments were conducted with the NSTX Liquid Lithium Divertor (LLD). Lithium evaporation recoated the LLD surface to approximate flowing liquid Li to sustain D retention. In the first experiment with the diverted outer strike poi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6066840f4d242dd2731ddfea3f1feb44
https://doi.org/10.1016/j.jnucmat.2013.01.100
https://doi.org/10.1016/j.jnucmat.2013.01.100
Autor:
Michael Jaworski, Robert Kaita, J. Kallman, H.W. Kugel, Vlad Soukhanovskii, Adam McLean, T.K. Gray, S.A. Sabbagh, D.P. Stotler, Filippo Scotti, M.G. Bell, I. Kaganovich, B.P. LeBlanc
Publikováno v:
Journal of Nuclear Materials. 438:S384-S387
The scrape-off layer plasma at the tokamak region is characterized by open field lines and often contains large variations in plasma properties along these field-lines. Proper characterization of local plasma conditions is critical to assessing plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66bba3a3dfc78cd2eb0bc45e2e80c69a
https://doi.org/10.1016/j.jnucmat.2013.01.076
https://doi.org/10.1016/j.jnucmat.2013.01.076
Autor:
Robert Kaita, Adam McLean, Michael Jaworski, Tyler Abrams, J. Kallman, E. L. Foley, Travis Gray, C.H. Skinner, Fred Levinton, H.W. Kugel
Publikováno v:
Journal of Nuclear Materials. 438:S313-S316
Samples of the NSTX Liquid Lithium Divertor (LLD) with and without an evaporative Li coating were directly exposed to a neutral beam ex-situ at a power of ~1.5 MW/m2 for 1-3 seconds. Measurements of front face and bulk sample temperature were obtaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::087b4a8dcee9c6af78472f33f10b8817
https://doi.org/10.1016/j.jnucmat.2013.01.057
https://doi.org/10.1016/j.jnucmat.2013.01.057