Rescue of the MERTK phagocytic defect in a human iPSC disease model using translational read-through inducing drugs

Autor: Conor M. Ramsden, Britta Nommiste, Amelia R. Lane, Amanda-Jayne F. Carr, Michael B. Powner, Matthew J. K. Smart, Li Li Chen, Manickam N. Muthiah, Andrew R. Webster, Anthony T. Moore, Michael E. Cheetham, Lyndon da Cruz, Peter J. Coffey

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract Inherited retinal dystrophies are an important cause of blindness, for which currently there are no effective treatments. In order to study this heterogeneous group of diseases, adequate disease models are required in order to better underst

Externí odkaz: https://doaj.org/article/2c6bb3edda1a42e7b46f27b3e51b9e86

Brief History and Use of Chemical Warfare Agents in Warfare and Terrorism

Autor: A. L. Ternay, J. A. Romano, J. K. Smart, B. J. Lukey, Harry Salem

Publikováno v: Chemical Warfare Agents ISBN: 9781498769235

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bb1bf9912f411b63e95623f25f7e3c1
https://doi.org/10.1201/9781498769235-1

Rescue of the MERTK phagocytic defect in a human iPSC disease model using translational read-through inducing drugs.

Autor: Ramsden CM; Department of Ocular Biology and Therapeutics (ORBIT), Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.; NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, EC1V 2PD, UK.; Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, London, EC1V 2PD, UK., Nommiste B; Department of Ocular Biology and Therapeutics (ORBIT), Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK., R Lane A; Department of Ocular Biology and Therapeutics (ORBIT), Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK., Carr AF; Department of Ocular Biology and Therapeutics (ORBIT), Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK., Powner MB; Department of Ocular Biology and Therapeutics (ORBIT), Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.; Division of Optometry and Visual Sciences, City University London, Northampton Square, London, EC1V 0HB, UK., J K Smart M; Department of Ocular Biology and Therapeutics (ORBIT), Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK., Chen LL; Department of Ocular Biology and Therapeutics (ORBIT), Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK., Muthiah MN; NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, EC1V 2PD, UK.; Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, London, EC1V 2PD, UK., Webster AR; Department of Ocular Biology and Therapeutics (ORBIT), Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.; NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, EC1V 2PD, UK., Moore AT; Department of Ocular Biology and Therapeutics (ORBIT), Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.; NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, EC1V 2PD, UK.; UCSF School of Medicine, Koret Vision Center, 10 Koret Way, San Francisco, CA 94143, USA., Cheetham ME; Department of Ocular Biology and Therapeutics (ORBIT), Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK., da Cruz L; Department of Ocular Biology and Therapeutics (ORBIT), Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.; NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, EC1V 2PD, UK.; Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, London, EC1V 2PD, UK., Coffey PJ; Department of Ocular Biology and Therapeutics (ORBIT), Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK. p.coffey@ucl.ac.uk.; NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, EC1V 2PD, UK. p.coffey@ucl.ac.uk.; Center for Stem Cell Biology and Engineering, NRI, UC Santa Barbara, USA. p.coffey@ucl.ac.uk.

Publikováno v: Scientific reports [Sci Rep] 2017 Mar 03; Vol. 7 (1), pp. 51. Date of Electronic Publication: 2017 Mar 03.