Zobrazeno 1 - 6
of 6
pro vyhledávání: '"J. K. Hickling"'
Publikováno v:
European Journal of Immunology. 22:1983-1987
A simple, cost-effective method is described that allows rapid screening of recombinant protein sequences for their ability to stimulate T cells. Individual microcultures of E. coli each expressing a gene product or peptide sequence fused to protein
Autor:
Jonathan B. Rothbard, H. Ikeda, G. A. J. Mcindoe, J. K. Hickling, Kevin Howland, G. Strang, D. Wilkinson
Publikováno v:
Journal of General Virology. 71:423-431
Four T cell determinants in the major capsid protein of human papillomavirus (HPV) type 16 L1 and one in the E6 protein associated with cellular transformation were defined using synthetic peptides to stimulate peripheral blood mononuclear cells from
Publikováno v:
International immunology. 2(5)
The mechanisms of antigen recognition employed by both class I and class II MHC-restricted T cells are very similar, yet many of the T cell determinants described to date are recognized in the context of a single class of MHC molecules, and generally
Publikováno v:
Journal of Virology. 61:3463-3469
The cytotoxic T-cell (Tc) response to varicella-zoster virus (VZV) is incompletely characterized. We investigated whether VZV-specific Tc restricted by class I products of the major histocompatibility complex can be generated from the peripheral bloo
Publikováno v:
European Journal of Immunology. 18:269-275
Human virus-specific cytotoxic T (Tc) cells may be important in maintaining the virus/host equilibrium during persistent herpes virus infections such as that with human cytomegalovirus (HCMV). We have previously shown that HCMV-specific Tc cells are
Autor:
M P Cranage, J K Hickling, J G Sissons, Geoffrey L. Smith, L K Borysiewicz, S Graham, J H Sinclair
Publikováno v:
The Journal of Experimental Medicine
CTL are held to be an important host defense mechanism in persistent herpes-virus infections. We have therefore studied the nature and specificity of human cytomegalovirus (HCMV)-specific CTL in normal persistently infected individuals. This was achi