Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J. K. Dulworth"'
Publikováno v:
Nucleosides and Nucleotides. 11:1595-1606
New conformationaly constrained cycloalkanol derivatives of guanine have been prepared as potential anti-herpetic agents. None of these compounds was found to inhibit HSV or CMV replication in cell culture but some of them show some antagonism or syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73385fc25e60fbc0981934e7237ad358
https://doi.org/10.1080/07328319208021352
https://doi.org/10.1080/07328319208021352
Autor:
J K Dulworth, Eric W. Lewis, Gary A. Thompson, Jacquelyn A. Smithers, Lianng Yuh, Henrik K. Kulmala, Michael T. Kenny, Kelly K. Antony
Publikováno v:
Biopharmaceutics & Drug Disposition. 13:213-220
Teicoplanin pharmacokinetics were investigated upon multiple dose intravenous administration of 6 and 12 mg kg-1 in 10 normal, healthy, male volunteers, using a two-period, randomized, crossover design; six subjects completed both periods. On day 1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f14855a65490b2a37e50cb5f893a16
https://doi.org/10.1002/bdd.2510130307
https://doi.org/10.1002/bdd.2510130307
Autor:
Kelly K. Antony, Michael T. Kenny, Jacquelyn A. Smithers, J K Dulworth, Gary A. Thompson, M A Brackman, Henrik K. Kulmala, Stephen J. Ruberg, Eric W. Lewis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:115-120
Teicoplanin pharmacokinetics were evaluated after multiple-dose intravenous administration to healthy male volunteers by using a randomized, double-blind, parallel design. Doses of 3, 12, or 30 mg of teicoplanin per kg of body weight were administere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ab95e970e9185efb25416cd1996280
https://doi.org/10.1128/aac.36.1.115
https://doi.org/10.1128/aac.36.1.115
Publikováno v:
Diagnostic Microbiology and Infectious Disease. 18:117-119
This study developed and validated a bioassay for ramoplanin in human, dog, rabbit, and rat sera. Mean analyte recoveries and coefficients of variation for duplicate assays with each serum using coded and spiked (30-720 ng/ml) samples ranged from 93.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207046b9859bab4dc6a3a997ee58eb53
https://doi.org/10.1016/0732-8893(94)90076-0
https://doi.org/10.1016/0732-8893(94)90076-0
Publikováno v:
Diagnostic Microbiology and Infectious Disease. 17:209-211
Ramoplanin is a glycolipodepsipeptide antibiotic active against Gram-positive bacteria. We observed that microdilution minimum inhibitory concentrations (MICs) were higher than those obtained in glass tubes or by agar dilution. Initial studies showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c43de25e3746a5078c659d150234b0
https://doi.org/10.1016/0732-8893(93)90098-r
https://doi.org/10.1016/0732-8893(93)90098-r
The in vitro activity of the semisynthetic glycopeptide amide MDL 63,246 against 293 U.S. clinical isolates of gram-positive cocci was determined by the broth microdilution method. When compared with teicoplanin, MDL 63,246 had improved activity agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627b19eb2c397f4adf62967ef0ed63e0
https://europepmc.org/articles/PMC162786/
https://europepmc.org/articles/PMC162786/
Autor:
Debra Taylor, Anne Eschbach, Francois Piriou, Michael T. Kenny, Serge Halazy, Stan Tyms, J K Dulworth, Tara Brennan, Jean-François Nave, Anne Eggenspiller
Publikováno v:
Antiviral research. 27(3)
(E)-9-(5-Phosphonopent-4-enyl)guanine and (E)-9-[3-(hydroxymethyl)-5-phosphonopent-4-enyl]guanine which bear a vinyl phosphonate moiety as a mimic of the phosphate group were synthesized. Their activities against human immunodeficiency virus type-1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75424a067cd8de6c657e232ba4f4e78c
https://pubmed.ncbi.nlm.nih.gov/8540751
https://pubmed.ncbi.nlm.nih.gov/8540751
Publikováno v:
Diagnostic microbiology and infectious disease. 15(7)
Comparative teicoplanin in vitro susceptibility data were generated for 1201 Gram-positive US clinical trial isolates using standardized broth microdilution and disk diffusion techniques. Based on the results of this study, the following interpretive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba6a920fb2ee4e8d464a6f8026671ba
https://pubmed.ncbi.nlm.nih.gov/1424518
https://pubmed.ncbi.nlm.nih.gov/1424518
Publikováno v:
Journal of Heterocyclic Chemistry. 21:261-263
9,10,11,12,12a,13-Hexahydro-2,3-dimethoxy-7H-naphtho[1,2--6]quinolizine hydrobromide (4), which has structural similarity to cell growth inhibitory alkaloid cryptopleurine (1), was found to inhibit the growth of HeLa cells by 50% versus control at a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::176b5591f13185a3bee3491130c1ffd1
https://doi.org/10.1002/jhet.5570210153
https://doi.org/10.1002/jhet.5570210153
Publikováno v:
Antimicrobial Agents and Chemotherapy. 30:516-518
The 6-substituted 2-(3',4'-dichlorophenoxy)-2H-pyrano[2,3-b]pyridines MDL 20,610 (6-SO2CH3), MDL 20,646 (6-Br), and MDL 20,957 (6-Cl) are potent antirhinovirus compounds with median plaque 50% inhibitory concentrations (IC1/2s) of 0.03, 0.006, and 0.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f044b4414bfb9a65585799bd4220f08a
https://doi.org/10.1128/aac.30.3.516
https://doi.org/10.1128/aac.30.3.516