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Autor:
J. Julia Wu, Neil Auricchio, Toren Finkel, Andrey A. Parkhitko, Jane J. Yu, Elizabeth P. Henske, Magdalena Karbowniczek, Faina Myachina, Khadijah M. Hindi, Tasha Morrison, David J. Kwiatkowski
Publikováno v:
Proceedings of the National Academy of Sciences. 108:12455-12460
Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome characterized by benign tumors in multiple organs, including the brain and kidney. TSC-associated tumors exhibit hyperactivation of mammalian target of rapamycin complex 1 (mTORC1), a di