Zobrazeno 1 - 10
of 476
pro vyhledávání: '"J. Jiricny"'
Autor:
J. Ferreira da Silva, G. P. Oliveira, E. A. Arasa-Verge, C. Kagiou, A. Moretton, G. Timelthaler, J. Jiricny, J. I. Loizou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Prime Editing is a versatile genome engineering tool. Here, the authors identify the DNA repair pathway known as mismatch repair as inhibitory for Prime Editing, thus, loss of mismatch repair enhances the efficiency of Prime Editing.
Externí odkaz:
https://doaj.org/article/c5eb288776124ca0807ead6fd587e370
Autor:
J. Ferreira da Silva, G. P. Oliveira, E. A. Arasa-Verge, C. Kagiou, A. Moretton, G. Timelthaler, J. Jiricny, J. I. Loizou
Publikováno v:
Nature Communications, 13
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Prime editing (PE) is a powerful genome engineering approach that enables the introduction of base substitutions, insertions and deletions into any given genomic locus. However, the efficiency of PE varies widely and depends not only on the genomic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460dd1ec11c0ff4ce39943f4974931dc
https://pubmed.ncbi.nlm.nih.gov/35140211
https://pubmed.ncbi.nlm.nih.gov/35140211
Akademický článek
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Publikováno v:
Journal of Virology. 68:3809-3820
The herpes simplex virus type 1 immediate-early protein ICP4 plays an essential role in the regulation of the expression of all viral genes. It is the major trans activator of early and late genes and also has a negative regulatory effect on immediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8e21767a5e8ce0d739535980488de7
https://doi.org/10.1128/jvi.68.6.3809-3820.1994
https://doi.org/10.1128/jvi.68.6.3809-3820.1994
Autor:
J Jiricny, M J Hughes
Publikováno v:
Journal of Biological Chemistry. 267:23876-23882
A mismatch-binding protein has been purified an estimated 4500-fold from HeLa nuclear extracts using four different chromatographic steps. Two polypeptides of apparent molecular weight of 160,000 and 100,000 were present in the final affinity-purifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1eb834781845a714409f8b40892ce43
https://doi.org/10.1016/s0021-9258(18)35918-0
https://doi.org/10.1016/s0021-9258(18)35918-0
Publikováno v:
Falk Symposium ISBN: 9781402068256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d026860c540b8d8f555e5350c50d97fd
https://doi.org/10.1007/978-1-4020-6826-3_3
https://doi.org/10.1007/978-1-4020-6826-3_3
Autor:
K, Zavodna, M, Bujalkova, T, Krivulcik, A, Alemayehu, M, Skorvaga, G, Marra, I, Fridrichova, J, Jiricny, Z, Bartosova
Publikováno v:
Neoplasma. 53(4)
Hereditary non-polyposis colorectal cancer (HNPCC) is associated with germline mutations in DNA mismatch repair genes, predominantly MSH2 and MLH1. Mutation carriers develop cancers in the colorectum, endometrium, ovary, stomach, small intestine and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::39972ac9f099dcc37f5542cf8b107227
https://pubmed.ncbi.nlm.nih.gov/16830052
https://pubmed.ncbi.nlm.nih.gov/16830052
Publikováno v:
Cancer research. 61(21)
Conversion of diploidy to haploidy is a method that allows the generation of stable murine/human hybrid cell lines carrying selected human chromosomes in only a single copy. In this setting, it is possible to detect genetic mutations with greater sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd2999a51caebcf407de016482ac4d4a
https://pubmed.ncbi.nlm.nih.gov/11691782
https://pubmed.ncbi.nlm.nih.gov/11691782
Publikováno v:
Progress in nucleic acid research and molecular biology. 68
More than 50% of colon cancer-associated mutations in the p53 tumor suppressor gene are C--T transitions. The majority of them locate in CpG dinucleotides and are thought to have arisen through spontaneous hydrolytic deamination of 5-methylcytosine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2a73c9f6151d89918fbab66025a1e87
https://pubmed.ncbi.nlm.nih.gov/11554300
https://pubmed.ncbi.nlm.nih.gov/11554300
Autor:
P, Schweizer, A L, Moisio, S A, Kuismanen, K, Truninger, R, Vierumäki, R, Salovaara, J, Arola, R, Butzow, J, Jiricny, P, Peltomäki, M, Nyström-Lahti
Publikováno v:
Cancer research. 61(7)
Hereditary nonpolyposis colorectal cancer syndrome is associated with an inherited predisposition to primarily colorectal cancer (CRC) and endometrial cancer (EC); however, the biological basis of the organ involvement remains unknown. As an attempt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5b68748eeba4c09fa2c9177db46db9f
https://pubmed.ncbi.nlm.nih.gov/11306449
https://pubmed.ncbi.nlm.nih.gov/11306449