Zobrazeno 1 - 10
of 60
pro vyhledávání: '"J. Jeremy Rice"'
Autor:
Wojciech Zareba, J. Jeremy Rice, Arthur A.M. Wilde, Wataru Shimizu, Jørgen K. Kanters, Coeli M. Lopes, Pyotr G. Platonov, Ilan Goldenberg, Scott McNitt, Matthias Reumann, Yiping Gu, Ryan Hoefen, Christian Jons, Jin O-Uchi, Arthur J. Moss
Publikováno v:
Journal of the American College of Cardiology. 60:2182-2191
Objectives The study was designed to assess the ability of computer-simulated electrocardiography parameters to predict clinical outcomes and to risk-stratify patients with long QT syndrome type 1 (LQT1). Background Although attempts have been made t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb906e785fecefca2baad3d2a14ac61
https://doi.org/10.1016/j.jacc.2012.07.053
https://doi.org/10.1016/j.jacc.2012.07.053
Publikováno v:
IEEE Transactions on Biomedical Engineering. 58:2965-2969
Future multiscale and multiphysics models that support research into human disease, translational medical science, and treatment can utilize the power of high-performance computing (HPC) systems. We anticipate that computationally efficient multiscal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5a31aa97709b38f69eabe32c70b5e9
https://doi.org/10.1109/tbme.2011.2161580
https://doi.org/10.1109/tbme.2011.2161580
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 457:1415-1422
Changes in developed force (0.1-3.0 microN) observed during contraction of single myofibrils in response to rapidly changing calcium concentrations can be measured using glass microneedles. These microneedles are calibrated for stiffness and deflect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539f51b1d9693fcc4f9fe71dfbf22fd1
https://doi.org/10.1007/s00424-008-0605-3
https://doi.org/10.1007/s00424-008-0605-3
Publikováno v:
Biophysical Journal. 95(5):2368-2390
We develop a point model of the cardiac myofilament (MF) to simulate a wide variety of experimental muscle characterizations including Force-Ca relations and twitches under isometric, isosarcometric, isotonic, and auxotonic conditions. Complex MF beh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab4e2715a3495728ddde20742df91a1
Publikováno v:
Proceedings of the National Academy of Sciences. 102:14266-14271
Recent observations show that the single-cell response of p53 to ionizing radiation (IR) is “digital” in that it is the number of oscillations rather than the amplitude of p53 that shows dependence on the radiation dose. We present a model of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ef0133c5fd95e8c3b3c09ed9c5bed3
https://doi.org/10.1073/pnas.0501352102
https://doi.org/10.1073/pnas.0501352102
Autor:
Anthony Hasseldine, Prahlad T. Ram, Avi Ma'ayan, J. Jeremy Rice, Robert D. Blitzer, Narat J. Eungdamrong, Elizabeth A. Grace, Benjamin J. Dubin-Thaler, Susana R. Neves, Ravi Iyengar, Gustavo Stolovitzky, Aaron Kershenbaum, Sherry L. Jenkins, Gehzi Weng
Publikováno v:
Science. 309:1078-1083
We developed a model of 545 components (nodes) and 1259 interactions representing signaling pathways and cellular machines in the hippocampal CA1 neuron. Using graph theory methods, we analyzed ligand-induced signal flow through the system. Specifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d212d14fd202af532684c60dd886bd67
https://doi.org/10.1126/science.1108876
https://doi.org/10.1126/science.1108876
Publikováno v:
Bioinformatics. 21:765-773
Motivation: One of the present challenges in biological research is the organization of the data originating from high-throughput technologies. One way in which this information can be organized is in the form of networks of influences, physical or s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4eff18716182ae2e4b6c29df8398cb6
https://doi.org/10.1093/bioinformatics/bti064
https://doi.org/10.1093/bioinformatics/bti064
Publikováno v:
Bioinformatics. 20:1033-1044
Motivation: Despite the growing literature devoted to finding differentially expressed genes in assays probing different tissues types, little attention has been paid to the combinatorial nature of feature selection inherent to large, high-dimensiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4b6cb4dc193c2d4a7b7896197dec3c
https://doi.org/10.1093/bioinformatics/bth035
https://doi.org/10.1093/bioinformatics/bth035
Autor:
Carole Mathis, Theodore Sakellaropoulos, Julia Hoeng, Raquel Norel, Gustavo Stolovitzky, J. Jeremy Rice, Manuel C. Peitsch, Ioannis N. Melas, Stéphanie Boué, Marja Talikka, Dimitris E Messinis, Pablo Meyer, Vincenzo Belcastro, Carine Poussin, Erhan Bilal, Leonidas G. Alexopoulos, Remi Dulize, Nikolai V. Ivanov, Kahn Rhrissorrakrai
Publikováno v:
Scientific Data
The biological responses to external cues such as drugs, chemicals, viruses and hormones, is an essential question in biomedicine and in the field of toxicology, and cannot be easily studied in humans. Thus, biomedical research has continuously relie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f969c27a7524fb761ac9166422eddb01
Publikováno v:
Europe PubMed Central
Length-dependent steady-state and dynamic responses of five models of isometric force generation in cardiac myofilaments were compared with similar experimental data from the literature. The models were constructed by assuming different subsets of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddcb82d4a92d430cb0db627c779f13b2
https://doi.org/10.1152/ajpheart.1999.276.5.h1734
https://doi.org/10.1152/ajpheart.1999.276.5.h1734