Zobrazeno 1 - 10
of 18
pro vyhledávání: '"J. Javier Hernandez"'
Autor:
Marie-Ming Aynaud, J. Javier Hernandez, Seda Barutcu, Ulrich Braunschweig, Kin Chan, Joel D. Pearson, Daniel Trcka, Suzanna L. Prosser, Jaeyoun Kim, Miriam Barrios-Rodiles, Mark Jen, Siyuan Song, Jess Shen, Christine Bruce, Bryn Hazlett, Susan Poutanen, Liliana Attisano, Rod Bremner, Benjamin J. Blencowe, Tony Mazzulli, Hong Han, Laurence Pelletier, Jeffrey L. Wrana
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Wide-spread outbreaks of pathogens require high intensity testing to manage. Here, the authors present C19-SPAR-Seq, a scalable and automated platform to analyse tens of thousands of SARS-CoV-2 patient samples in a single run.
Externí odkaz:
https://doaj.org/article/ac044901fa7a4d629bfedd519a0399c2
Autor:
Angela Duong, Alesya Evstratova, Adam Sivitilli, J. Javier Hernandez, Jessica Gosio, Azizia Wahedi, Neal Sondheimer, Jeff L. Wrana, Jean-Martin Beaulieu, Liliana Attisano, Ana C. Andreazza
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Mitochondrial health plays a crucial role in human brain development and diseases. However, the evaluation of mitochondrial health in the brain is not incorporated into clinical practice due to ethical and logistical concerns. As a result, t
Externí odkaz:
https://doaj.org/article/07e67ce070a84572b832c40c4b1c99f0
Autor:
J. Javier Hernandez, Michael Pryszlak, Lindsay Smith, Connor Yanchus, Naheed Kurji, Vijay M. Shahani, Steven V. Molinski
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
The repositioning or “repurposing” of existing therapies for alternative disease indications is an attractive approach that can save significant investments of time and money during drug development. For cancer indications, the primary goal of re
Externí odkaz:
https://doaj.org/article/d0fd9d77c9ce4c72a6ca6c16b6a7145f
Autor:
Connor Yanchus, Kristen L. Drucker, Thomas M. Kollmeyer, Ricky Tsai, Warren Winick-Ng, Minggao Liang, Ahmad Malik, Judy Pawling, Silvana B. De Lorenzo, Asma Ali, Paul A. Decker, Matt L. Kosel, Arijit Panda, Khalid N. Al-Zahrani, Lingyan Jiang, Jared W. L. Browning, Chris Lowden, Michael Geuenich, J. Javier Hernandez, Jessica T. Gosio, Musaddeque Ahmed, Sampath Kumar Loganathan, Jacob Berman, Daniel Trcka, Kulandaimanuvel Antony Michealraj, Jerome Fortin, Brittany Carson, Ethan W. Hollingsworth, Sandra Jacinto, Parisa Mazrooei, Lily Zhou, Andrew Elia, Mathieu Lupien, Housheng Hansen He, Daniel J. Murphy, Liguo Wang, Alexej Abyzov, James W. Dennis, Philipp G. Maass, Kieran Campbell, Michael D. Wilson, Daniel H. Lachance, Margaret Wrensch, John Wiencke, Tak Mak, Len A. Pennacchio, Diane E. Dickel, Axel Visel, Jeffrey Wrana, Michael D. Taylor, Gelareh Zadeh, Peter Dirks, Jeanette E. Eckel-Passow, Liliana Attisano, Ana Pombo, Cristiane M. Ida, Evgeny Z. Kvon, Robert B. Jenkins, Daniel Schramek
Publikováno v:
Science
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold greater risk of isocitrate dehydrogenase ( IDH) –mutant low-grade gli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0962bd008ed19485d953421b33939b
https://doi.org/10.1126/science.abj2890
https://doi.org/10.1126/science.abj2890
Autor:
Liliana Attisano, Laurence Pelletier, Philippos Peidis, Tony Mazzulli, Miriam Barrios-Rodiles, Marie-Ming Aynaud, Sharon J. Hyduk, Joel Pearson, James R. Woodgett, Kin Chan, Jeffrey L. Wrana, Daniel Trcka, Myron I. Cybulsky, Mark Jen, Suying Lu, Rod Bremner, J. Javier Hernandez
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-12 (2021)
Virology Journal
Virology Journal
BackgroundSensitive, rapid, and accessible diagnostics continue to be critical to track the COVID-19 pandemic caused by the SARS-CoV-2 virus. RT-qPCR is the gold standard test, and comparison of methodologies and reagents, utilizing patient samples,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b8b6aa73d0a666510b35c0fd3b5057
https://doaj.org/article/550187229e544508bd7d16774946297a
https://doaj.org/article/550187229e544508bd7d16774946297a
Autor:
Jess Shen, Ulrich Braunschweig, Joel Pearson, Jeffrey L. Wrana, Laurence Pelletier, Benjamin J. Blencowe, Jaeyoun Kim, Siyuan Song, Suzanna L. Prosser, Tony Mazzulli, Seda Barutcu, Bryn Hazlett, Miriam Barrios-Rodiles, Daniel Trcka, Mark Jen, Liliana Attisano, Rod Bremner, Marie-Ming Aynaud, J. Javier Hernandez, Christine Bruce, Susan M. Poutanen, Kin Chan, Hong Han
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
Population scale sweeps of viral pathogens, such as SARS-CoV-2, require high intensity testing for effective management. Here, we describe “Systematic Parallel Analysis of RNA coupled to Sequencing for Covid-19 screening” (C19-SPAR-Seq), a multip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8014a69803c78646cfdde4bec31c22
https://doaj.org/article/ac044901fa7a4d629bfedd519a0399c2
https://doaj.org/article/ac044901fa7a4d629bfedd519a0399c2
Autor:
Connor Yanchus, Kristen L. Drucker, Thomas M. Kollmeyer, Ricky Tsai, Minggao Liang, Lingyan Jiang, Judy Pawling, Asma Ali, Paul Decker, Matt Kosel, Arijit Panda, Ahmad Malik, Khalid N. Al-Zahrani, J. Javier Hernandez, Musaddeque Ahmed, Sampath Kumar Loganathan, Daniel Trcka, Antony Michaelraj, Jerome Fortin, Parisa Mazrooei, Lily Zhou, Andrew Elia, Mathieu Lupien, Housheng Hansen He, Liguo Wang, Alexej Abyzov, James W. Dennis, Michael D. Wilson, Jeffrey Wrana, Daniel Lachance, Margaret Wrensch, John Wiencke, Len A. Pennacchio, Diane E. Dickel, Axel Visel, Michael Taylor, Gelareh Zadeh, Peter Dirks, Jeanette E. Eckel-Passow, Tak Mak, Evgeny Kvon, Robert B. Jenkins, Daniel Schramek
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single nucleotide polymorphism rs55705857 (A>G), which confers a 6-fold increased risk of IDH-mutant low-grade glioma (LGG) and is amongst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::180fd8f9c159efa7af618e701ec0e230
https://doi.org/10.1101/2022.03.08.22272044
https://doi.org/10.1101/2022.03.08.22272044
Autor:
Laurence Pelletier, Ulrich Braunschweig, Kin F. Chan, Marie-Ming Aynaud, Siyuan Song, Hong Han, Jeffrey L. Wrana, Tony Mazzulli, Jaeyoun Kim, Rod Bremner, J. Javier Hernandez, Seda Barutcu, Christine Bruce, Miriam Barrios-Rodiles, Suzanna L. Prosser, Liliana Attisano, Jess Shen, Bryn Hazlett, Daniel Trcka, Joel Pearson, Susan M. Poutanen, Mark Jen, Benjamin J. Blencowe
Population scale sweeps of viral pathogens, such as SARS-CoV-2, require high intensity testing for effective management. This protocol describes the “Systematic Parallel Analysis of RNA coupled to Sequencing for Covid-19 screening” (C19-SPAR-Seq)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ef2bfdebed268baf53ab271fb561efe
https://doi.org/10.21203/rs.3.pex-1356/v1
https://doi.org/10.21203/rs.3.pex-1356/v1
Autor:
Tony Mazzulli, Laurence Pelletier, Jeffrey L. Wrana, James R. Woodgett, Sharon J. Hyduk, Myron I. Cybulsky, Filippos Peidis, Marie-Ming Aynaud, Rod Bremner, J. Javier Hernandez, Daniel Trcka, Liliana Attisano, Suying Lu, Joel Pearson, Kin Chan
The COVID-19 pandemic caused by the SARS-CoV-2 virus has placed extensive strain on RNA isolation and RT-qPCR reagents. Rapid development of new test kits has helped to alleviate these shortages. However, comparisons of these new detection systems ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6be5b07a6d5d95c48fd67459f80273f
Autor:
J. Javier Hernandez, Parisa Ghiasi, Adam Sivitilli, Jean-Martin Beaulieu, Jeffrey L. Wrana, Alesya Evstratova, Daniel Trcka, Liliana Attisano, Jessica Gosio, Bibaswan Ghoshal
Publikováno v:
Life Science Alliance
By leveraging advances in 3D stem cell culture techniques, the authors describe, characterize and validate a novel platform to efficiently generate morphologically consistent human forebrain cerebral organoids.
Human cerebral organoid (hCO) mode
Human cerebral organoid (hCO) mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80bb9c616c4ac5278f954b69d0aaea2