Zobrazeno 1 - 10
of 30
pro vyhledávání: '"J. Javier Díaz-Mejía"'
Today’s single-cell RNA analysis tools provide enormous value in enabling researchers to make sense of large single-cell RNA (scRNA) studies, yet their ability to integrate different studies at scale remains untested. Here we present a novel benchm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92c3fae3bf805deb1ddde3c2fce4312a
https://doi.org/10.1101/2021.12.08.471773
https://doi.org/10.1101/2021.12.08.471773
Autor:
Antony Tin, Lillian L. Siu, Nickolas Attanasio, David P. Goldstein, Tina Shek, Bayardo Perez-Ordonez, J. Javier Díaz-Mejía, Ronald Shazer, Anna Spreafico, Douglas B. Chepeha, Ben X Wang, Ilan Weinreb, Hirak Der-Torossian, Andrew Hope, Aaron R. Hansen, Daniel Vilarim Araujo, Qingyan Au, Amy Prawira, John R. de Almeida, Alexey Aleshin, Jordan Feeney, Marc Oliva, Peter Olson, Stephen M. Smith, Jonathan C. Irish, Jeff Bruce, Anthony Fortuna, Himanshu Sethi, Isan Chen, Trevor J. Pugh, Dax Torti, Scott V. Bratman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundSitravatinib, a tyrosine kinase inhibitor that targets TYRO3, AXL, MERTK and the VEGF receptor family, is predicted to increase the M1 to M2-polarized tumor-associated macrophages ratio in the tumor microenvironment and have synergistic ant
Autor:
J. Javier Díaz-Mejía, Mazdak Riverin, Suluxan Mohanraj, Shamini Ayyadhury, Fiona J. Coutinho, Danielle C Croucher, Peter B. Dirks, Trevor J. Pugh, Laura M. Richards
Tumours are routinely profiled with single-cell RNA sequencing (scRNA-seq) to characterize their diverse cellular ecosystems of malignant, immune, and stromal cell types. When combining data from multiple samples or studies, batch-specific technical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb25cba4a1a5a059324def2e3424fe7a
https://doi.org/10.1101/2021.08.04.453579
https://doi.org/10.1101/2021.08.04.453579
Autor:
Hillary Elrick, Kevin L Lu, Mia Husić, Laura M. Richards, Parisa Shooshtari, Suluxan Mohanraj, Ping Luo, Samarth Patel, Erik Christensen, Danielle C Croucher, Alaine Naidas, Shaikh Rashid, Trevor J. Pugh, Arun K. Ramani, Prabnur Bal, Alaina Mahalanabis, J. Javier Díaz-Mejía, Martin D. Pham, Michael Brudno
Publikováno v:
Nucleic Acids Research
Paediatrics Publications
Paediatrics Publications
CReSCENTCanceR Single Cell ExpressioN Toolkit (https://crescent.cloud), is an intuitive and scalable web portal incorporating a containerized pipeline execution engine for standardized analysis of single-cell RNA sequencing (scRNA-seq) data. While sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c334f4b28de8a2054a2c90b681227b91
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
David G. Coffey, Francesco Maura, Edgar Gonzalez-Kozlova, J. Javier Diaz-Mejia, Ping Luo, Yong Zhang, Yuexin Xu, Edus H. Warren, Travis Dawson, Brian Lee, Hui Xie, Eric Smith, Amanda Ciardiello, Hearn J. Cho, Adeeb Rahman, Seunghee Kim-Schulze, Benjamin Diamond, Alexander Lesokhin, Dickran Kazandjian, Trevor J. Pugh, Damian J. Green, Sacha Gnjatic, Ola Landgren
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The role of the immune microenvironment in maintaining disease remission in patients with multiple myeloma (MM) is not well understood. In this study, we comprehensively profile the immune system in patients with newly diagnosed MM receiving
Externí odkaz:
https://doaj.org/article/f009262e72e74d7eb9e4d2fcf98a1f75
Autor:
Alexander R. Pico, John H. Morris, J. Javier Díaz-Mejía, Elaine C. Meng, Gary D. Bader, Krishna Choudhary
Publikováno v:
F1000Research
Single-cell RNA-sequencing (scRNA-seq) has revolutionized molecular biology and medicine by enabling high-throughput studies of cellular heterogeneity in diverse tissues. Applying network biology approaches to scRNA-seq data can provide useful insigh
Autor:
Sonya A. MacParland, John H. Morris, Gary D. Bader, Elaine C. Meng, J. Javier Díaz-Mejía, Troy Ketela, Trevor J. Pugh, Alexander R. Pico
Publikováno v:
F1000Research
Background: Identification of cell type subpopulations from complex cell mixtures using single-cell RNA-sequencing (scRNA-seq) data includes automated steps from normalization to cell clustering. However, assigning cell type labels to cell clusters i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651b854db0a322a9d6710dbf92909f57
https://doi.org/10.1101/562082
https://doi.org/10.1101/562082
Autor:
Miriam S. Reuter, Dustin J. Sokolowski, J. Javier Diaz-Mejia, Johannes Keunen, Barbra de Vrijer, Cadia Chan, Liangxi Wang, Greg Ryan, David A. Chiasson, Troy Ketela, Stephen W. Scherer, Michael D. Wilson, Edgar Jaeggi, Rajiv R. Chaturvedi
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Low blood flow through the fetal left heart is often conjectured as an etiology for hypoplastic left heart syndrome (HLHS). To investigate if a decrease in left heart flow results in growth failure, we generate left ventricular inflow obstru
Externí odkaz:
https://doaj.org/article/8284083b8cd142eb97e9e9c59d7a03d6
Autor:
Cassandra Wong, Gaurav Gupta, Daniel Durocher, J. Javier Díaz-Mejía, Frederick P. Roth, Pritpal Bansal, Anna Karkhanina, D'Arcy Prendergast, Joseph C. Mellor, Albi Celaj, Fatemeh Shaeri, Atina G. Cote, Grant W. Brown, Marta Verby, Justin Rich, Jochen Weile, Sedide Ozturk, YiFan Zhang, Brandon Ho, Marinella Gebbia, Attila Balint
Publikováno v:
Molecular Systems Biology
Condition-dependent genetic interactions can reveal functional relationships between genes that are not evident under standard culture conditions. State-of-the-art yeast genetic interaction mapping, which relies on robotic manipulation of arrays of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0b1c7b850bb5d03888ad09c7d73d6c