Zobrazeno 1 - 10
of 104
pro vyhledávání: '"J. J. Vanden Eynde"'
Autor:
Jean-Marie Colet, Raphael Conotte, Bertrand Blankert, Maxime Helvenstein, J.-J. Vanden Eynde, Zehra Cagla Kahvecioglu, L. Verdy, Stéphanie Hambye
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 95:54-60
Pentamidine isethionate (PTMD) is an antiprotozoal agent used in different parasitic diseases as Human African Trypanosomiasis or Pneumocystis pneumonia. Given its side effects, numerous analogs are still under development worldwide. PTMD has been re
Autor:
Olivier Denis, Emmanuel Gosselin, J. Conti, A. Van Cauwenberge, J.-J. Vanden Eynde, Kris Huygen, J. De Coninck
Publikováno v:
Sensors and Actuators B: Chemical. :549-555
Verrucarin A2 (VerA) is a toxic trichothecene mycotoxin that can be produced indoors at very low level by moulds contaminating dwellings and may be associated with several human health problems. In this study we describe a spectroscopic label-free bi
Autor:
Delphine Forge, Tien Huang, Dimitri Stanicki, J.-J. Vanden Eynde, Julien Laurent, Davie Cappoen, Annie Mayence, Luc Verschaeve, Kris Huygen
Publikováno v:
European Journal of Medicinal Chemistry. 49:95-101
Despite progress in modern chemotherapy to combat tuberculosis, the causative pathogen Mycobacterium tuberculosis (M.tb.) is far from eradicated. Bacillary resistance to anti-mycobacterial agents, bacillary persistence and human immunodeficiency viru
Autor:
J.-J. Vanden Eynde, A. Maquestiau
Publikováno v:
Bulletin des Sociétés Chimiques Belges. 95:641-648
Reactions between five β-dicarbonyl compounds (1–5) or their enaminocarbonyl analogues (6–10) and three heterocyclic amines (12–14) are studied. The two types of carbonyl derivatives give rise to the formation of the same final products. Kinet
Publikováno v:
Bulletin des Sociétés Chimiques Belges. 94:575-583
Reactions between 4-amino-3-penten-2-one, ethyl 3-amino-2-butenoate or 3-amino-2-butenanilide and phenyl isocyanate yield mixtures of N- and C-adducts. Quantitative data allow to check the influence of the electronwithdrawing groups in the enaminocar
Publikováno v:
Bulletin des Sociétés Chimiques Belges. 98:523-528
A comparison is established for the reactivity of benzaldehyde, N-(1-chlorobenzyl)pyridinium chloride or N-(1-chlorobenzyl)pyrimidinium chloride with several poorly nucleophilic and/or poorly soluble primary amines under mild experimental conditions.
Publikováno v:
Bulletin des Sociétés Chimiques Belges. 93:1073-1081
Various 1,3-disubstituted pyrazolin-5-ones, 3-phenylisoxazolin-5-one and 2-phenyloxazolin-5-one react with ethyl 3-amino-2-butenoate to yield compounds resulting from the elimination of ammonia between the precursors; subsequent intramolecular cycliz
Publikováno v:
Bulletin des Sociétés Chimiques Belges. 101:233-236
N-(1-Chloroalkyl)pyridinium chlorides, prepared from thionyl chloride, pyridine, and an aldehyde, readily react with N,N′-disubstituted 1,2-ethanediamine to yield imidazolidines under mild and neutral conditions.
Publikováno v:
Bulletin des Sociétés Chimiques Belges. 101:801-806
Conversion of aldehydes into N-(1-chloroalkyl) pyridinium chlorides (by means of pyridine and thionyl chloride) and further reaction with 3-(2-aminophenyl)amino-5,5-dimethyl-2-cyclohexenone provide a novel and efficient route to the title compounds.
Publikováno v:
Bulletin des Sociétés Chimiques Belges. 87:309-320
A number of 1-R-3-hydroxypyrazolo [3,4-b] pyridines are obtained by cyclocondensation of a 1-R-5-aminopyrazolin-3-one with β-dicarbonyl compounds. The first step of this synthesis involves the most reactive carbonyl group exclusively and, competitiv