Výsledky vyhledávání - "J. J. Oppenheim"

Autor: J. J. Oppenheim, D. Yang

Publikováno v: Medical Mycology. 47:S146-S153

Alarmins are endogenous mediators capable of enhancing innate and adaptive immune response through induction of concomitant recruitment and activation of antigen-presenting cells. Here we provide a brief overview of various alarmins, highlight their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8df2548afde250bf4ca51d65c7e0b2
https://doi.org/10.1080/13693780902721416

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Inhibition of Tyrosine Kinase Activation Blocks the Down-Regulation of CXC Chemokine Receptor 4 by HIV-1 gp120 in CD4+ T Cells

Autor: S B, Su, W, Gong, M, Grimm, I, Utsunomiya, R, Sargeant, J J, Oppenheim, J, Ming Wang

Publikováno v: The Journal of Immunology. 162:7128-7132

Because the binding of HIV-1 envelope to CD4 initiates a configurational change in glycoprotein 120 (gp120), enabling it to interact with fusion coreceptors, we investigated how this process interferes with the expression and function of CXC chemokin

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https://doi.org/10.4049/jimmunol.162.12.7128

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Small molecule inhibitor of HIV-1 cell fusion blocks chemokine receptor-mediated function

Autor: Jim A. Turpin, J. J. Oppenheim, Michael Grimm, William G. Rice, Christopher J. Michejda, Robert Blumenthal, Nadya I. Tarasova, O. M. Z. Howard, Thomas Korte

Publikováno v: Journal of Leukocyte Biology. 64:6-13

The intersection of the HIV and the chemokine fields began with the observation that HIV entry into cells could be blocked by certain chemokines. Subsequent work showed that HIV entry is dependent on the presence of specific chemokine receptors. Thes

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https://doi.org/10.1002/jlb.64.1.6

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Synergy of IL-1 and stem cell factor in radioprotection of mice is associated with IL-1 up-regulation of mRNA and protein expression for c-kit on bone marrow cells

Autor: R Neta, J J Oppenheim, J M Wang, C M Snapper, M A Moorman, C M Dubois

Publikováno v: The Journal of Immunology. 153:1536-1543

Administration of IL-1 and stem cell factor (SCF) to mice 18 h before lethal 60Co whole-body irradiation resulted in synergistic radioprotection, as evidenced by increased numbers of mice surviving 1,200 to 1,300 cGy doses of radiation and the recove

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https://doi.org/10.4049/jimmunol.153.4.1536

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Human recombinant macrophage inflammatory protein-1 alpha and -beta and monocyte chemotactic and activating factor utilize common and unique receptors on human monocytes

Autor: J M Wang, B Sherry, M J Fivash, D J Kelvin, J J Oppenheim

Publikováno v: The Journal of Immunology. 150:3022-3029

The human macrophage inflammatory proteins-1 alpha and -beta (MIP-1 alpha and -beta), which are also known as LD78 and ACT2, respectively, are distinct but highly related members of the chemoattractant cytokine (chemokine) family. rMIP-1 alpha and -b

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https://doi.org/10.4049/jimmunol.150.7.3022

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IL-1 and tumor necrosis factor-alpha each up-regulate both the expression of IFN-gamma receptors and enhance IFN-gamma-induced HLA-DR expression on human monocytes and a human monocytic cell line (THP-1)

Autor: T Krakauer, J J Oppenheim

Publikováno v: The Journal of Immunology. 150:1205-1211

Stimulation of human blood monocytes (adherent mononuclear cells) and the monocytic cell line, THP-1, by IL-1 or TNF-alpha leads to the up-regulation of IFN-gamma receptors. Scatchard analysis using 125I-IFN-gamma revealed a twofold increase in the n

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https://doi.org/10.4049/jimmunol.150.4.1205

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IL-4 inhibits the costimulatory activity of IL-2 or picolinic acid but not of lipopolysaccharide on IFN-gamma-treated macrophages

Autor: G W Cox, U Chattopadhyay, J J Oppenheim, L Varesio

Publikováno v: The Journal of Immunology. 147:3809-3814

We reported previously that IL-2 induces tumoricidal activity in IFN-gamma-treated murine macrophages. The present study was performed to investigate the regulation of IL-2-dependent tumoricidal activity in murine macrophage cell lines. The v-raf/v-m

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https://doi.org/10.4049/jimmunol.147.11.3809

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Chemoprotective effects of recombinant human IL-1 alpha in cyclophosphamide-treated normal and tumor-bearing mice. Protection from acute toxicity, hematologic effects, development of late mortality, and enhanced therapeutic efficacy

Autor: H Futami, R Jansen, M J MacPhee, J Keller, K McCormick, D L Longo, J J Oppenheim, F W Ruscetti, R H Wiltrout

Publikováno v: The Journal of Immunology. 145:4121-4130

In this study, recombinant human IL-1 alpha (rhIL-1 alpha) was used to protect normal and tumor-bearing BALB/c mice from the acute toxicity caused by lethal doses of cyclophosphamide (Cy) and 5-fluorouracil. Pretreatment of mice for 7 days with 10,00

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https://doi.org/10.4049/jimmunol.145.12.4121

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Functional activation of human neutrophils by recombinant monocyte-derived neutrophil chemotactic factor/IL-8

Autor: J Y Djeu, K Matsushima, J J Oppenheim, K Shiotsuki, D K Blanchard

Publikováno v: The Journal of Immunology. 144:2205-2210

Monocyte-derived neutrophil chemotactic factor (MDNCF)/IL-8, a novel cytokine, distinct from IL-1 and TNF was recently purified and cloned. This study was performed to investigate the biologic effect of recombinant MDNCF/IL-8 on human polymorphonucle

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https://doi.org/10.4049/jimmunol.144.6.2205

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