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pro vyhledávání: '"J. J. Mackichan"'
High-Performance Liquid Chromatographic Determination of CGA-184699 (Lufenuron) in Dog and Cat Blood
Autor:
J. J. Mackichan, W. F. Hink
Publikováno v:
Journal of Liquid Chromatography. 16:2595-2604
A method for quantitation of lufenuron (CGA-184699) in blood was developed for the purpose of determining lufenuron pharmacokinetics in cats and dogs. Lufenuron is an investigational insect development inhibitor used in the control of fleas on cats a
Publikováno v:
Acta cardiologica. 46(1)
Publikováno v:
Clinical Chemistry. 30:768-773
We measured procainamide and its active metabolite, N-acetylprocainamide (NAPA), in 80 sera from 37 patients by a new fluorimmunoassay procedure and an established "high-performance" liquid-chromatographic method. Additive and proportional difference
Publikováno v:
Research communications in chemical pathology and pharmacology. 20(3)
A sensitive and specific fluorometric high pressure liquid chromatography technique was used to measure propranolol concentrations in the plasma of three healthy volunteers following an oral 10 mg dose of propranolol hydrochloride. Peak propranolol c
Publikováno v:
Clinical pharmacology and therapeutics. 22(5 Pt 1)
An example from the literature has been used to demonstrate errors involved in calculating drug clearance by inappropriate use of the apparent drug distribution volume Vdext. The Vdext is always an overestimate of the true volume of distribution in a
Publikováno v:
The American journal of gastroenterology. 73(3)
The bioavailability of two commercial formulations of hydrocortisone rectal enemas, Rectoid and Cortenema, was determined in 12 normal volunteers. Relative to an intravenous dose, 50--90% of a dose given rectally was available to the systemic circula
Publikováno v:
Clinical chemistry. 25(6)
We describe a method for simultaneous quantitation of diazepam and its metabolites, N-desmethyldiazepam and oxazepam, by reversed-phase liquid chromatography with ultraviolet detection at 254 nm. After extraction with chloroform at pH 11.0, the organ
Publikováno v:
Research communications in chemical pathology and pharmacology. 44(2)
Twenty-five indocyanine green (ICG) clearance determinations were performed in four subjects in the presence of quinidine or propranolol before and after one week of treatment with cimetidine, 1200 mg/day, and following a single 600 mg cimetidine dos
Autor:
MacKichan, JJ, Zola, EM
Publikováno v:
British Journal of Clinical Pharmacology; 1984, Vol. 18 Issue 4, p487-493, 7p
Publikováno v:
Biopharmaceutics & Drug Disposition; 1989, Vol. 10 Issue 1, p121-125, 5p