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Humoral response of cynomolgus macaques to human soluble CD4: Antibody reactivity restricted to xeno-human determinants

Autor: Martin Rosenberg, Alemseged Truneh, Raymond Sweet, Patricia A. Thiem, J. J. Leary, Nabil Hanna, Peter J. Bugelski, Robert L. Frescatore

Publikováno v: Cellular Immunology. 131:98-108

The CD4 cell surface glycoprotein which is expressed primarily by a subset of T lymphocytes plays a key role in normal immune responses. In the immunopathogenesis of AIDS, it serves as the high-affinity receptor for HIV, facilitating viral attachment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125cf7e62648b272487a902103a36f2a
https://doi.org/10.1016/0008-8749(90)90237-l

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Synergistic drug interactions of an HIV-1 protease inhibitor with AZT in different in vitro models of HIV-1 infection

Autor: C. Bratby-Anders, Brian W. Metcalf, A. V. Fernandez, J. J. Leary, H. Bartus, Dennis M. Lambert, Geoffrey B. Dreyer, Stephen R. Petteway

Publikováno v: Antiviral research. 21(4)

Synthetic peptide mimetic inhibitors of HIV-1 protease effectively block spread of infectious virus in acutely infected T-cells. These compounds also inhibit production of infectious virions from chronically infected T-cell lines. In order to determi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8405b7d8c0e741a7b37bffffbcc7d628
https://pubmed.ncbi.nlm.nih.gov/7692816

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Morphometric analysis of recombinant soluble CD4-mediated release of the envelope glycoprotein gp120 from HIV-1

Autor: Joanne Miller, Dennis M. Lambert, Timothy K. Hart, Stephen A. Petteway, Harma Ellens, Richard Kirsh, Peter J. Bugelski, J. J. Leary

Publikováno v: AIDS research and human retroviruses. 6(10)

The results indicate that sT4 (CD4) can modify mature and budding HIV virions, possibly influencing infectivity, by enhancing the removal of gp120 from the viral membrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238b58d13f869bcdc8dcc2d60c8f97d2
https://pubmed.ncbi.nlm.nih.gov/2252640

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Use of biotinylated probes for detecting sickle cell anemia

Autor: J J Leary, J T Wilson, G J Garbutt, George S. Schuster, D C Ward

Publikováno v: Clinical Chemistry. 31:1203-1206

Earlier, we reported that the 5' end of the normal beta-globin gene (beta) resides on a 1.14-kilobase DNA fragment, whereas the 5' end of the sickle cell gene (beta s) resides on a 1.34-kilobase fragment. In that blot hybridization analysis, we used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ad2543685a55d358d2da9eae1e94c77
https://doi.org/10.1093/clinchem/31.7.1203

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Construction of an infectious molecular clone of the autonomous parvovirus minute virus of mice

Autor: M J Merchlinsky, S F Cotmore, E M Gardiner, David C. Ward, J J Leary, Peter Tattersall

Publikováno v: Journal of Virology. 47:227-232

The linear single-stranded DNA genome of minute virus of mice, an autonomous parvovirus, was cloned in duplex form into the bacterial plasmid pBR322. The recombinant clones of minute virus of mice were infectious when transfected into monolayers of h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5d1dabb5c6dc20230989691bc25b9d
https://doi.org/10.1128/jvi.47.1.227-232.1983

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Use of biotinylated probes for detecting sickle cell anemia

Autor: G J, Garbutt, J T, Wilson, G S, Schuster, J J, Leary, D C, Ward

Publikováno v: Clinical chemistry. 31(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::723f8db2f6a08372ebc7706842a9d71c
https://pubmed.ncbi.nlm.nih.gov/2988824

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