Výsledky vyhledávání - "J. J. Koenig"

Reversible inhibition of type B monoamine oxidase. Theoretical study of model diazo heterocylic compound

Autor: J. J. Koenig, Johan Wouters, F. Durant, S. Jegham, Pascal George, Frédéric Ooms

Publikováno v: European Journal of Medicinal Chemistry. 32:721-730

Summary Different families of heterocycles containing 2 to 4 nitrogen atoms (oxadiazolones, tetrazoles and oxadiazinone derivatives, so-called diazoheterocyclics) are currently used as lead compounds for the design of reversible and selective monoami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade9c1879b57461aa41a25e224fd0d5a
https://doi.org/10.1016/s0223-5234(97)88914-3

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A reversible monoamine oxidase inhibitor, Toloxatone: comparison of its physicochemical properties with those of other inhibitors including Brofaromine, Harmine, R40519 and Moclobemide

Autor: F. Ducrey, M Depas, Johan Wouters, J. J. Koenig, F. Moureau, Daniel P. Vercauteren, François Durant, F.X. Jarreau

Publikováno v: European Journal of Medicinal Chemistry. 30:823-837

Summary Reversible, competitive and selective monoamine oxidase A inhibitors (MAO A Is) are an exciting new type of anti-depressants with a safe profile. The mechanism for reversible inhibition of MAO A at the molecular level is still unknown. The pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49e6f29bbc1e233ebda473549e51be71
https://doi.org/10.1016/0223-5234(96)88302-4

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ChemInform Abstract: Use of Chiral Glycerol 2,3-Carbonate in the Synthesis of 3-Aryl-2-oxazolidinones

Autor: Y. Guminski, A. Nedelec, Pascal George, Ph. Burnier, J. J. Koenig, S. Jegham, F. Puech

Publikováno v: ChemInform. 29

Substituted chiral 3-aryl-2-oxazolidinones were readily prepared via regiospecific opening of cyclic carbonates with N -arylcarbamates and subsequent cyclization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8249f3b99982eaf9be87018cb853685
https://doi.org/10.1002/chin.199836172

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A reversible monoamine oxidase inhibitor, toloxatone: Structural and electronic properties

Autor: Guy Evrard, François Durant, Johan Wouters, J. J. Koenig, F. Moureau, Sonia Collin, F. Ducrey, Daniel P. Vercauteren, F.X. Jarreau

Publikováno v: European Journal of Medicinal Chemistry. 27:939-948

Toloxatone is a reversible MAOA-inhibitor, marketed as antidepressant (Humoryl®), with an original chemical structure. It differs from first generation irreversible MAOIs, known to induce covalent bonds with the enzyme active site. In order to under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2624bcf563af34f0e819e7f29f4f855d
https://doi.org/10.1016/0223-5234(92)90026-w

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Kinetics of a new iodolabeled MAO-B inhibitor in the rat brain and in cultured astrocytes

Autor: J L, Moretti, C, Blanchot, P, Nicolas, L, Artaud, J J, Koenig, F X, Jarreau, R, Germack, G, Defer, G, Perret

Publikováno v: Journal of nuclear biology and medicine (Turin, Italy : 1991). 38(4 Suppl 1)

3-Bromobenzyloxy phenyloxy hydroxymethyl propanol was labelled with iodine-125. Labeling yield was approximately 92%. Using HPLC and an RP18 column, Iodo*MD (MW = 412) was obtained at no-carrier-added conditions (specific activity 125 Ci/mmole). Bioc

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https://pubmed.ncbi.nlm.nih.gov/7632770

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Experimental and theoretical study of reversible monoamine oxidase inhibitors: structural approach of the active site of the enzyme

Autor: F. Ducrey, François Durant, F. Moureau, J. J. Koenig, F.X. Jarreau, Johan Wouters, Daniel P. Vercauteren, Guy Evrard

Publikováno v: Amine Oxidases: Function and Dysfunction ISBN: 9783211825211

Experimental and theoretical physico-chemical methods were used to investigate the interaction between aryl-oxazolidinones and monoamine oxidase (MAO). Several arguments suggest that these compounds interact with the flavin adenine dinucleotide (FAD)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b31946704800574cfc61e1dde436dd7
https://doi.org/10.1007/978-3-7091-9324-2_41

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Experimental and theoretical study of reversible monoamine oxidase inhibitors: structural approach of the active site of the enzyme

Autor: J, Wouters, F, Moureau, D P, Vercauteren, G, Evrard, F, Durant, J J, Koenig, F, Ducrey, F X, Jarreau

Publikováno v: Journal of neural transmission. Supplementum. 41

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8c33509ee3be0b1a2c4dae95493b488
https://pubmed.ncbi.nlm.nih.gov/7931244

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