Zobrazeno 1 - 10
of 41
pro vyhledávání: '"J. J. Kettenes-Van Den Bosch"'
Autor:
Josbert M. Metselaar, Gert Storm, Birgit Romberg, K. Motonaga, Wim E. Hennink, T. deVringer, J. J. Kettenes-van den Bosch, C. Oussoren
Publikováno v:
Bioconjugate Chemistry. 16:767-774
Liposomes coated with poly(hydroxyethyl L-glutamine) (PHEG) show prolonged circulation times and biodistribution patterns comparable to PEG-coated liposomes. While PEG is a nondegradable polymer, PHEG is expected to be hydrolyzed by proteases. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37539cc5038eaa20fd3442e261fca67
https://doi.org/10.1021/bc0497719
https://doi.org/10.1021/bc0497719
Autor:
Auke Bult, Antonella Flaibani, J. J. Kettenes-van den Bosch, Gianni Sava, M. Bouma, Bastiaan Nuijen, Alberto Perbellini, Herre Talsma, Jos H. Beijnen, M.J. van Steenbergen
Publikováno v:
International Journal of Pharmaceutics. 248:247-259
This paper describes the development of a stable pharmaceutical dosage form for NAMI-A, a novel antimetastatic ruthenium complex, for Phase I testing. NAMI-A drug substance was characterized using several spectrometric and chromatographic techniques.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791a8ef7c9b41d3f344578f1e79e907c
https://doi.org/10.1016/s0378-5173(02)00459-3
https://doi.org/10.1016/s0378-5173(02)00459-3
Autor:
C.F. van Nostrum, Loes M. J. Kroon-Batenburg, S. J. de Jong, Wim E. Hennink, J. J. Kettenes-van den Bosch
Publikováno v:
Journal of Applied Polymer Science. 86:289-293
Physically crosslinked hydrogels are formed upon mixing equal amounts of aqueous solutions of dextran grafted with L-lactic acid oligomers and dextran grafted with D-lactic acid oligomers. In this paper, the dex-lactate hydrogels are analyzed by X-ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c8d44527538d7d13c815a9730d9f21
https://doi.org/10.1002/app.10954
https://doi.org/10.1002/app.10954
Publikováno v:
Langmuir. 18:3466-3470
For poly(ethylene glycol)-derivatized liposomes (PEG−liposomes), the chemical stability of both the phospholipid ester groups and the urethane anchor between the PEG chain and the phospholipid are two important factors determining their long-term s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67338b811876ec2f570145ef88f1f1ad
https://doi.org/10.1021/la011589y
https://doi.org/10.1021/la011589y
Autor:
C. P. Noain, Manada C, M. Bouma, I. M. Rodrigues-Campos, Jos H. Beijnen, Pablo Floriano, Auke Bult, J. J. Kettenes-van den Bosch, Bastiaan Nuijen
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 24:3119-3139
The development and validation of a reversed-phase high performance liquid chromatographic (RP-HPLC) method with ultra-violet (UV) detection for the quantification and purity determination of aplidine in raw drug substance and pharmaceutical dosage f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6848f1db8802ce57ca726a2a1b102694
https://doi.org/10.1081/jlc-100107724
https://doi.org/10.1081/jlc-100107724
Autor:
M. Bouma, Auke Bult, Pablo Floriano, E. Stokvis, Bastiaan Nuijen, Hilde Rosing, Manada C, Jos H. Beijnen, J. J. Kettenes-van den Bosch
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 24:3141-3155
Kahalalide F is a cyclic depsipeptide derived from the marine mollusc Elysia rufescens, an organism living in the seas near Hawaii. On the basis of its in vitro and in vivo selectivity, kahalalide F is currently developed as a potential anticancer ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18c0c87dfc249c30c96eb660b81fd036
https://doi.org/10.1081/jlc-100107725
https://doi.org/10.1081/jlc-100107725
Autor:
Joseph Demeester, J. J. Kettenes-van den Bosch, S.C. De Smedt, Wim E. Hennink, S. J. de Jong, C.F. van Nostrum
Publikováno v:
Journal of Controlled Release. 72:47-56
A novel hydrogel system in which crosslinking is established by stereocomplex formation between lactic acid oligomers of opposite chirality is proposed. To investigate the feasibility of this novel system, we first investigate whether there is an ope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0669b3da49c4b5426db93cdc73ed25a6
https://doi.org/10.1016/s0168-3659(01)00261-9
https://doi.org/10.1016/s0168-3659(01)00261-9
Autor:
B. van Eerdenbrugh, C.F. van Nostrum, S. J. de Jong, Wim E. Hennink, J. J. Kettenes-van den Bosch
Publikováno v:
Journal of Controlled Release. 71:261-275
Hydrogels, physically crosslinked through stereocomplex formation, were obtained by mixing aqueous solutions of dextran with l -lactic acid grafts and dextran with d -lactic acid grafts. Protein-loaded hydrogels were simply prepared by dissolving the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a8ca705eaf91a225ccd85c21ee1d96
https://doi.org/10.1016/s0168-3659(01)00228-0
https://doi.org/10.1016/s0168-3659(01)00228-0
Autor:
Dirk T. S. Rijkers, E.R Arias, S. J. de Jong, C.F. van Nostrum, Wim E. Hennink, J. J. Kettenes-van den Bosch
Publikováno v:
Polymer. 42:2795-2802
The hydrolytic degradation of monodisperse lactic acid oligomers was studied in vitro to gain insight into the degradation of oligolactic acid grafted to dextran, which we use for the preparation of hydrogels based on physical interactions, or the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08d1eceae52d93f3b85c8915ac2b71db
https://doi.org/10.1016/s0032-3861(00)00646-7
https://doi.org/10.1016/s0032-3861(00)00646-7
Autor:
Thomas Kerbusch, Matthijs M. Tibben, A. D. R. Huitema, Sjoerd Rodenhuis, Jos H. Beijnen, J. J. Kettenes van den Bosch
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 23:1725-1744
A reversed-phase high performance liquid chromatographic (HPLC) method for the determination of the activated cyclophosphamide (CP) metabolite 4-hydroxycyclophosphamide (4-OHCP) in human plasma and red blood cells is described. 4-OHCP is very unstabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13f852767dabd37d0c3e6135475de07c
https://doi.org/10.1081/jlc-100100448
https://doi.org/10.1081/jlc-100100448