Výsledky vyhledávání - "J. J. Godfroid"

Total synthesis of 12( R )-HETE, 12( S )-HETE, 2 H 2 -12( R )-HETE and LTB 4 from racemic glycidol via hydrolytic kinetic resolution

Autor: J. J. Godfroid, Miguel Nomen, Ana R. Rodriguez, Tak H. Lee, Bernd W. Spur

Publikováno v: Tetrahedron. 57:25-37

The total synthesis of 12(R)-HETE, 12(S)-HETE (Samuelsson's HETE), [14,15-2H2]-12(R)-HETE and Leukotriene B4 from racemic glycidol is described. The key steps are the hydrolytic kinetic resolution of racemic TES-glycidol with salen-Co catalyst and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcae92a6cdeab4a12fd166eb5979203e
https://doi.org/10.1016/s0040-4020(00)00983-2

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PMS-601, a New Platelet-Activating Factor Receptor Antagonist That Inhibits Human Immunodeficiency Virus Replication and Potentiates Zidovudine Activity in Macrophages

Autor: G. Le Pavec, Marc Martin, Nathalie Dereuddre-Bosquet, G. Fichet, Françoise Heymans, Nawal Serradji, Dominique Dormont, J. J. Godfroid, Aazdine Lamouri, Pascal Clayette

Publikováno v: Antimicrobial Agents and Chemotherapy. 44:3150-3154

We assessed the anti-human immunodeficiency virus (anti-HIV) activity in vitro of new platelet-activating factor (PAF) receptor antagonists, as PAF and viral replication are thought to be involved in HIV neuropathogenesis. We found that PMS-601 inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84c531096ddb67f1e057c70b9f0ea42
https://doi.org/10.1128/aac.44.11.3150-3154.2000

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Total synthesis of lipoxin A4 and lipoxin B4 from butadiene

Autor: J. J. Godfroid, Miguel Nomen, Ana R. Rodriguez, Bernd W. Spur, Tak H. Lee

Publikováno v: Tetrahedron Letters. 41:823-826

The total synthesis of LXA4 and LXB4 has been achieved starting from butadiene via palladium catalyzed telomerization. Sharpless catalytic AE and C-2 inversion of the 2(S),3(S)-epoxy alcohols, using Myers CO2/Cs2CO3 procedure, generated the asymmetri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d3f5b7c7c41065e5505bdf7662aa363
https://doi.org/10.1016/s0040-4039(99)02201-7

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Selective oxidation of primary silyl ethers and its application to the synthesis of natural products

Autor: Ana R. Rodriguez, Miguel Nomen, Bernd W. Spur, J. J. Godfroid

Publikováno v: Tetrahedron Letters. 40:5161-5164

Primary TMS or TES ethers, in the presence of secondary TMS or TES ethers, are selectively oxidized to the corresponding aldehydes under Swern conditions. A short synthesis of key intermediates towards various natural products has been achieved.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00caf0a83a2caf9c13a9c1daf2fe8e95
https://doi.org/10.1016/s0040-4039(99)00956-9

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A selective method for the preparation of aliphatic methyl esters in the presence of aromatic carboxylic acids

Autor: J. J. Godfroid, Bernd W. Spur, Ana R. Rodriguez, Miguel Nomen

Publikováno v: Tetrahedron Letters. 39:8563-8566

2,2-Dimethoxypropane, methanol and a catalytic amount of HCl selectively esterify aliphatic carboxylic acids, in the presence of aromatic carboxylic acids, at room temperature and in high yields.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e104147466f5682de9576f80088ca876
https://doi.org/10.1016/s0040-4039(98)01958-3

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Structure of 5-(3,4,5-trimethoxyphenyl)-2-iodomethyltetrahydrofuran: a precursor of acetylcholinesterase inhibitors with platelet-activating factor antagonistic activity

Autor: S. Halut-Desportes, Edith Favre, J.-J. Godfroid, L. Le Texier

Publikováno v: Acta Crystallographica Section B Structural Science. 51:863-867

The trans configuration of an iodomethyltetrahydrofuran derivative (2) has been determined as part of a structure-activity relationships study of acetylcholinesterase inhibitors with correlated platelet-activating factor antagonistic activity. Synthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7b201cfd89a038c01adf67462ed6303
https://doi.org/10.1107/s0108768195000541

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ChemInform Abstract: A Selective Method for the Preparation of Aliphatic Methyl Esters in the Presence of Aromatic Carboxylic Acids

Autor: J. J. Godfroid, Bernd W. Spur, Ana R. Rodriguez, Miguel Nomen

Publikováno v: ChemInform. 30

2,2-Dimethoxypropane, methanol and a catalytic amount of HCl selectively esterify aliphatic carboxylic acids, in the presence of aromatic carboxylic acids, at room temperature and in high yields.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f0292b0bcd7ba6a4105e9a95ed34995
https://doi.org/10.1002/chin.199907074

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ChemInform Abstract: Selective Oxidation of Primary Silyl Ethers and Its Application to the Synthesis of Natural Products

Autor: Ana R. Rodriguez, Bernd W. Spur, J. J. Godfroid, Miguel Nomen

Publikováno v: ChemInform. 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0188231b36a286a725f405d8b71a6bf4
https://doi.org/10.1002/chin.199940060

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[Antiretroviral ant anti-inflammatory properties of a novel platelet activation factor antagonist, PMS-601]

Autor: M, Martin, N, Serradji, N, Dereuddre-Bosquet, O, Bensaïd, G, Fichet, A, Lamouri, F, Heymans, P, Clayette, J J, Godfroid, D, Dormont

Publikováno v: Pathologie-biologie. 48(5)

The platelet-activating factor (PAF) plays a major role in neuropathogenesis associated with human immunodeficiency virus (HIV) infection by enhancing the inflammatory syndrome and viral replication, particularly in cells of the macrophage lineage, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d5ef248ff9bfa879214b1d45c07703b
https://pubmed.ncbi.nlm.nih.gov/10949851

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