Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis

Autor: Martin G. Rowlands, S.E. Barrie, Raymond McCague, J. J. Deadman, John Houghton, Michael Jarman

Publikováno v: Journal of Medicinal Chemistry. 33:2452-2455

In a search for inhibitors of 17 alpha-hydroxylase-C17,20-lyase and testosterone-5 alpha-reductase, target enzymes in the development of drugs to treat hormone-dependent prostatic cancer, we have identified certain compounds chemically derived by the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b36403ce6a4efb3da0916c8631663e1
https://doi.org/10.1021/jm00171a019

Synthetic RGD peptides derived from the adhesive domains of snake-venom proteins: evaluation as inhibitors of platelet aggregation

Autor: Xinjie Lu, John A. Williams, Salman Rahman, Vijay V. Kakkar, J. J. Deadman

Publikováno v: The Biochemical journal. 296

Synthetic peptides based on the RGD domains of the potent platelet aggregation inhibitors kistrin and dendroaspin were generated. The 13-amino-acid peptides were synthesized as dicysteinyl linear and disulphide cyclic forms. In platelet-aggregation s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da258a3f12084e8b20ae8dd938a36232
https://pubmed.ncbi.nlm.nih.gov/8250845

ChemInform Abstract: A Benzoquinone Diimine from the Oxidation of Pentafluoroaniline by Hypochlorite. X-Ray Crystal Structure and Possible Formation via Pentafluorophenylnitrene

Autor: Stephen Neidle, Michael Jarman, J. J. Deadman, Raymond McCague, Robert McKenna

Publikováno v: ChemInform. 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f069b274dad92b6be3364440c15613da
https://doi.org/10.1002/chin.198947152

How to Find a Fragment: Methods for Screening and Validation in Fragment-Based Drug Discovery.

Autor: Kirkman T; Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK., Dos Santos Silva C; Department of Microbiology, Institute of Biomedical Science, University of São Paulo, Av. Prof. Lineu Prestes, 1374, CEP 05508-000, São Paulo, SP, Brazil., Tosin M; Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK., Bertacine Dias MV; Department of Microbiology, Institute of Biomedical Science, University of São Paulo, Av. Prof. Lineu Prestes, 1374, CEP 05508-000, São Paulo, SP, Brazil.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Dec 16; Vol. 19 (24), pp. e202400342. Date of Electronic Publication: 2024 Nov 04.

Synthesis of peptide homo‐ and heterodimers as potential mimics of platelet‐derived growth factor BB.

Autor: Stubbing, Louise A.¹ (AUTHOR), Kaur, Harveen¹ (AUTHOR), Feng, Sheryl X.^2,3 (AUTHOR), Aalderink, Miranda^2,3 (AUTHOR), Dragunow, Michael^2,3 (AUTHOR), Brimble, Margaret A.¹ (AUTHOR) m.brimble@auckland.ac.nz

Publikováno v: Peptide Science. Jul2020, Vol. 112 Issue 4, p1-17. 17p.