Výsledky vyhledávání - "J. J. Casciari"

Growth rate, labeling index, and radiation survival of cells grown in the matrigel threadin vitro tumor model

Autor: L. K. Chin, R. G. Steen, J. C. Livesey, D. Boyles, J. J. Casciari, J. S. Rasey

Publikováno v: Scopus-Elsevier

Six rodent cell lines (36B10 rat glioma cells, 9L rat gliosarcoma cells, V79 Chinese hamster lung fibroblasts, EMT6/UW and EMT6/Ro mouse mammary sarcoma cells, and RIF-1 mouse fibrosarcoma cells) were tested for growth in cylindrical threads of Matri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db465faa027249144c1d7164f451875
https://doi.org/10.1007/bf02634310

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A modeling approach for quantifying tumor hypoxia with [F-18]fluoromisonidazole PET time-activity data

Autor: M. M. Graham, J. S. Rasey, J. J. Casciari

Publikováno v: Medical Physics. 22:1127-1139

[F-18]fluoromisonidazole (FMISO), a positron-emitting nitroimidazole, binds preferentially to hypoxic cells. It has been used to image hypoxia in human tumors with positron emission tomography (PET). In order to quantify tumor oxygenation status from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d87a1130dea4d1390515729e5ad6f88
https://doi.org/10.1118/1.597506

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Determination of the radiobiologically hypoxic fraction in multicellular spheroids from data on the uptake of [3H]fluoromisonidazole

Autor: J J, Casciari, J S, Rasey

Publikováno v: Radiation research. 141(1)

Fluoromisonidazole [1-(2-nitroimidazolyl)-2-hydroxy-3-fluoropropane, FMISO] shows promise as a hypoxia imaging agent: it binds preferentially to anoxic cells in monolayers in vitro and accumulates in radiobiologically hypoxic tumors in vivo. The mult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f766d43e01cff2846523d8086f7814b
https://pubmed.ncbi.nlm.nih.gov/7997512

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Noninvasive detection of hypoxic myocardium using fluorine-18-fluoromisonidazole and positron emission tomography

Autor: G V, Martin, J H, Caldwell, M M, Graham, J R, Grierson, K, Kroll, M J, Cowan, T K, Lewellen, J S, Rasey, J J, Casciari, K A, Krohn

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 33(12)

Fluoromisonidazole (FMISO) is metabolically trapped in viable cells as a function of reduced cellular pO2. Therefore [18F]-FMISO is potentially useful for evaluating patients with hypoxic but viable myocardium. The goal of this study was to investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2918510ead5ea06364166a4ac6bc0d93
https://pubmed.ncbi.nlm.nih.gov/1460516

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Determination of the Radiobiologically Hypoxic Fraction in Multicellular Spheroids from Data on the Uptake of [ 3 H]Fluoromisonidazole

Autor: J. J. Casciari, J. S. Rasey

Publikováno v: Radiation Research. 141:28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31168e36bea6ff7e42584048cb3bd11e
https://doi.org/10.2307/3579086

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Glucose diffusivity in multicellular tumor spheroids

Autor: J J, Casciari, S V, Sotirchos, R M, Sutherland

Publikováno v: Cancer research. 48(14)

In order to understand the role of glucose limitations in controlling multicellular tumor spheroid growth, knowledge of the glucose diffusion coefficient is essential. The effective diffusivity of glucose in spheroids of rodent and human tumor cell l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b8c1f7aadb6e119f8290c52919c874d
https://pubmed.ncbi.nlm.nih.gov/3383189

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