Výsledky vyhledávání - "J. J. CONKLIN"

Synthesis and evaluation of radioiodinated derivatives of 1-azabicyclo[2.2.2]oct-3-yl .alpha.-hydroxy-.alpha.-(4-iodophenyl)-.alpha.-phenylacetate as potential radiopharmaceuticals

Autor: W. C. Eckelman, Barbara Francis, R. C. Reba, Michael P. Grissom, R.R. Eng, Elaine M. Jagoda, Raymond E. Gibson, J. J. Conklin, D. A. Simms, W. J. Rzeszotarski

Publikováno v: Journal of Medicinal Chemistry. 27:156-160

Two derivatives of (RS)-1-azabicyclo[2.2.2]oct-3-yl (RS)-alpha-hydroxy-alpha-(4-iodophenyl)-alpha-phenylacetate (1a) and three partially resolved (R)- or (S)-1-azabicyclo[2.2.2]oct-3-yl (RS)-alpha-hydroxy-alpha-(4-iodophenyl)-alpha-phenylacetates lab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a21c22477ddea99b60e93f13f663ff8
https://doi.org/10.1021/jm00368a009

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Cardiovascular performance with E. coli challenges in a canine model of human sepsis

Autor: J. J. Conklin, Charles Natanson, M. P. Fink, Joseph E. Parrillo, Thomas J. MacVittie, Robert L. Danner, R. I. Walker

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 254:H558-H569

We investigated cardiovascular dysfunction by injecting lethal and nonlethal bacterial challenges into conscious dogs. E. coli bacteria of varying numbers were placed in a peritoneal clot. Cardiovascular function was studied with simultaneous radionu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e129b48ab4dde7f3604c7b687b2c21
https://doi.org/10.1152/ajpheart.1988.254.3.h558

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External Imaging of Cerebral Muscarinic Acetylcholine Receptors

Autor: J. J. Conklin, T Hill, Rzeszotarski Warclaus J, Raymond E. Gibson, Michael P. Grissom, Thomas F. Budinger, Richard C. Reba, BL Holman, William C. Eckelman, R.R. Eng

Publikováno v: Science. 223:291-293

A radioiodinated ligand that binds to muscarinic acetylcholine receptors was shown to distribute in the brain by a receptor-mediated process. With single-photon-emission imaging techniques, radioactivity was detected in the cerebrum but not in the ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76f20fc1ef62bd520b1a0b083aa268d
https://doi.org/10.1126/science.6608148

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Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock

Autor: M. P. Fink, H K Ballantyne, Joseph E. Parrillo, Charles Natanson, Thomas J. MacVittie, J. J. Conklin

A canine sepsis model that simulates the human cardiovascular response to septic shock was produced in 10 conscious unsedated dogs by implanting an Escherichia coli-infected clot into the peritoneum, resulting in bacteremia. By employing serial, simu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fef8b163e3c58559b9210b60558984
https://europepmc.org/articles/PMC329557/

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Effects of a metastatic (13762) and nonmetastatic (R3230AC) mammary adenocarcinoma on radiocolloid localization in regional lymph nodes in Fischer 344 rats

Autor: G N, Ege, J B, Nold, R R, Eng, A, Durakovic, J J, Conklin

Publikováno v: Journal of the Reticuloendothelial Society. 34(6)

Effects of a metastatic and nonmetastatic tumor on radiocolloid localization in regional lymph nodes in the rat were studied in order to examine further the hypothesis that suppression of radiocolloid uptake results from inhibition of macrophage phag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::478dddcb7d54ea00e109a74b391b7cb3
https://pubmed.ncbi.nlm.nih.gov/6655643

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Altered gastric emptying and prevention of radiation-induced vomiting in dogs

Autor: A, Dubois, J P, Jacobus, M P, Grissom, R R, Eng, J J, Conklin

Publikováno v: Gastroenterology. 86(3)

The relation between radiation-induced vomiting and gastric emptying is unclear and the treatment of this condition is not established. We explored, therefore, (a) the effect of cobalt 60 irradiation on gastric emptying of solids and liquids and (b)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d693c05e496588644331d1adc5bf90bf
https://pubmed.ncbi.nlm.nih.gov/6363196

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Effect of gamma-irradiation on the healing of gastric biopsy sites in monkeys. An experimental model for peptic ulcer disease and gastric protection

Autor: A, Dubois, E, Danquechin Dorval, L R, Wood, J E, Rogers, L, O'Connell, A, Durakovic, J J, Conklin

Publikováno v: Gastroenterology. 88(1 Pt 2)

The acute effects of gamma-irradiation on the gastric mucosa have been studied in a primate model. Fiberoptic gastroscopies were performed in 6 rhesus monkeys in the basal state as well as 3 h and 3, 7, and 9 days after total body irradiation (800 ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f7226b87701ca0d4c2ad8aeaef4e277
https://pubmed.ncbi.nlm.nih.gov/3964784

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Comparison of bone scan and radiograph sensitivity in the detection of steroid-induced ischemic necrosis of bone

Autor: D S Hungerford, T M Zizic, A Gober, Henry N. Wagner, Philip O. Alderson, J Y Densereaux, J J Conklin

Publikováno v: Radiology. 147(1)

A prospective study of bone scanning for detection of ischemic necrosis of bone (INB) was performed in 36 patients (97% female, age range 16-36 yrs.) with systemic lupus erythematosis (SLE). Since the hips, knees, and shoulders are usually affected b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37340266f54330effbd1ad0a4775986c
https://pubmed.ncbi.nlm.nih.gov/6219425

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